| APIS288 |
LockinE |
Type II Thoeris |
CLAN003 |
|
PMID:41785351 |
Lockin-family type II Thoeris inhibitor; expected to neutralize the type II Thoeris signal His-ADPR. |
| APIS288 |
LockinA |
Type I Thoeris,Type II Thoeris |
CLAN003 |
B. subtilis phage SBSphiJ |
PMID:41785351 |
act as nucleotide “sponges,” binding 1′′–3′ glycocyclic adenosine diphosphate–ribose (3′caDPr) and histidine conjugated to aDPr (his- aDPr) |
| APIS288 |
LockinD |
Type I Thoeris,Type II Thoeris |
CLAN003 |
|
PMID:41785351 |
Lockin-family anti-defense sponge active against both type I and type II Thoeris; likely neutralizes 3′cADPR and His-ADPR immune signals. |
| APIS359 |
LockinB |
Type I Thoeris |
CLAN003 |
|
PMID:41785351 |
Lockin-family type I Thoeris inhibitor; sponge protein that sequesters 3′cADPR, preventing Thoeris effector activation. |
| LockinC |
LockinC |
Type I Thoeris |
CLAN003 |
|
PMID:41785351 |
Lockin-family sponge protein; inhibits type I Thoeris by trapping 3′cADPR. |
| APIS240 |
Tad6 |
type I Thoeris |
CLAN016 |
|
PMID:39855193 |
Tad3, Tad4, and Tad6 each have a conserved loop that blocks the active site pocket and interacts with the catalytic E85 residue of the type I ThsB |
| APIS258 |
Tad4 |
type I Thoeris |
CLAN015 |
|
PMID:39855193 |
Tad3, Tad4, and Tad6 each have a conserved loop that blocks the active site pocket and interacts with the catalytic E85 residue of the type I ThsB. |
| APIS351 |
Tad3 |
type I Thoeris |
CLAN014 |
|
PMID:39855193 |
Tad3, Tad4, and Tad6 each have a conserved loop that blocks the active site pocket and interacts with the catalytic E85 residue of the type I ThsB. |
| Tad5 |
Tad5 |
type I Thoeris |
CLAN052 |
|
PMID:39855193 |
Tad5 can interact with E85 and other active site residues in ThsB but does not completely block the active site pocket. |
| APIS214 |
|
|
CLAN014 |
|
|
|
| APIS219 |
|
|
CLAN015 |
|
|
|
| APIS220 |
|
|
CLAN003 |
|
|
|
| APIS226 |
|
|
CLAN003 |
|
|
|
| APIS228 |
|
|
CLAN003 |
|
|
|
| APIS232 |
|
|
CLAN015 |
|
|
|
| APIS234 |
|
|
CLAN003 |
|
|
|
| APIS238 |
|
|
CLAN016 |
|
|
|
| APIS241 |
|
|
CLAN016 |
|
|
|
| APIS243 |
|
|
CLAN014 |
|
|
|
| APIS246 |
|
|
CLAN003 |
|
|
|
| APIS248 |
|
|
CLAN003 |
|
|
|
| APIS249 |
|
|
CLAN015 |
|
|
|
| APIS253 |
|
|
CLAN014 |
|
|
|
| APIS261 |
|
|
CLAN052 |
|
|
|
| APIS266 |
|
|
CLAN003 |
|
|
|
| APIS272 |
|
|
CLAN003 |
|
|
|
| APIS277 |
|
|
CLAN016 |
|
|
|
| APIS284 |
|
|
CLAN003 |
|
|
|
| APIS285 |
|
|
CLAN003 |
|
|
|
| APIS290 |
|
|
CLAN003 |
|
|
|
| APIS295 |
|
|
CLAN014 |
|
|
|
| APIS296 |
|
|
CLAN015 |
|
|
|
| APIS299 |
|
|
CLAN003 |
|
|
|
| APIS303 |
|
|
CLAN003 |
|
|
|
| APIS304 |
|
|
CLAN003 |
|
|
|
| APIS313 |
|
|
CLAN003 |
|
|
|
| APIS319 |
|
|
CLAN015 |
|
|
|
| APIS321 |
|
|
CLAN003 |
|
|
|
| APIS326 |
|
|
CLAN016 |
|
|
|
| APIS330 |
|
|
CLAN014 |
|
|
|
| APIS335 |
|
|
CLAN003 |
|
|
|
| APIS342 |
|
|
CLAN014 |
|
|
|
| APIS347 |
|
|
CLAN016 |
|
|
|
| APIS358 |
|
|
CLAN003 |
|
|
|
| APIS364 |
|
|
CLAN003 |
|
|
|
| APIS370 |
|
|
CLAN003 |
|
|
|
| APIS376 |
|
|
CLAN016 |
|
|
|
| APIS377 |
|
|
CLAN015 |
|
|
|
