Browse anti-prokaryotic immune system families by CLAN ID

AD families AD genes Defense system CLAN ID Phages/MGEs References Description
APIS288 LockinE Type II Thoeris CLAN003 PMID:41785351 Lockin-family type II Thoeris inhibitor; expected to neutralize the type II Thoeris signal His-ADPR.
APIS288 LockinA Type I Thoeris,Type II Thoeris CLAN003 B. subtilis phage SBSphiJ PMID:41785351 act as nucleotide “sponges,” binding 1′′–3′ glycocyclic adenosine diphosphate–ribose (3′caDPr) and histidine conjugated to aDPr (his- aDPr)
APIS288 LockinD Type I Thoeris,Type II Thoeris CLAN003 PMID:41785351 Lockin-family anti-defense sponge active against both type I and type II Thoeris; likely neutralizes 3′cADPR and His-ADPR immune signals.
APIS359 LockinB Type I Thoeris CLAN003 PMID:41785351 Lockin-family type I Thoeris inhibitor; sponge protein that sequesters 3′cADPR, preventing Thoeris effector activation.
LockinC LockinC Type I Thoeris CLAN003 PMID:41785351 Lockin-family sponge protein; inhibits type I Thoeris by trapping 3′cADPR.
APIS220 CLAN003
APIS226 CLAN003
APIS228 CLAN003
APIS234 CLAN003
APIS246 CLAN003
APIS248 CLAN003
APIS266 CLAN003
APIS272 CLAN003
APIS284 CLAN003
APIS285 CLAN003
APIS290 CLAN003
APIS299 CLAN003
APIS303 CLAN003
APIS304 CLAN003
APIS313 CLAN003
APIS321 CLAN003
APIS335 CLAN003
APIS358 CLAN003
APIS364 CLAN003
APIS370 CLAN003