| APIS024 |
Tad1 |
Thoeris |
CLAN001 |
SBSphiJ7 of B. subtilis |
PMID:36174646 |
Tad1 proteins are not an enzymes, but are 'sponges' that bind and sequester the immune signaling molecule (cyclic ADP-ribose or gcADPR) produced by TIR-domain proteins, thus decoupling phage sensing from immune effector activation and rendering Thoeris inactive. |
| APIS029 |
Tad2 |
Thoeris |
CLAN001 |
Bacillus phage SPO1 |
Yirmiya et al., 2023 |
Tad2 is a "sponge" that sequesters the immune signaling molecules produced by Thoeris TIR-domain proteins in response to phage. |
| APIS043 |
|
|
CLAN001 |
Pasteurella phage Pm86 |
|
|
| APIS045 |
|
|
CLAN001 |
|
|
|
| APIS052 |
|
|
CLAN001 |
|
|
|
| APIS061 |
|
|
CLAN001 |
|
|
|
| APIS070 |
|
|
CLAN001 |
|
|
|
| APIS079 |
|
|
CLAN001 |
Pseudomonas phage Skulduggery |
|
|
| APIS211 |
SequestinJ |
Thoeris |
CLAN001 |
|
PMID:41785351 |
Thoeris anti-defense sponge; sequesters 3′cADPR and blocks ThsA activation |
| APIS245 |
SequestinM |
Thoeris |
CLAN001 |
|
PMID:41785351 |
Sequestin-family anti-defense protein; inhibits type I Thoeris signaling, most likely by binding 3′cADPR. |
| APIS283 |
SequestinD |
Thoeris |
CLAN001 |
|
PMID:41785351 |
Thoeris anti-defense sponge; sequesters 3′cADPR and blocks ThsA activation |
| APIS283 |
SequestinE |
Thoeris |
CLAN001 |
|
PMID:41785351 |
Thoeris anti-defense sponge; sequesters 3′cADPR and blocks ThsA activation |
| APIS315 |
SequestinK |
Thoeris |
CLAN001 |
|
PMID:41785351 |
Sequestin-family Thoeris inhibitor; anti-defense protein that blocks the 3′cADPR → ThsA signaling pathway. |
| APIS315 |
SequestinB |
Thoeris |
CLAN001 |
|
PMID:41785351 |
Anti-Thoeris Sequestin-family sponge; neutralizes Thoeris signaling by trapping 3′cADPR and blocking downstream NAD-depletion defense. |
| APIS315 |
SequestinL |
Thoeris |
CLAN001 |
|
PMID:41785351 |
Viral anti-Thoeris sponge; binds/sequesters ADPR-derived Thoeris signal molecules and prevents growth-arrest/cell-death defense. |
| APIS315 |
SequestinH |
Thoeris |
CLAN001 |
|
PMID:41785351 |
Phage Sequestin homolog; functions as a Thoeris inhibitor by preventing immune-signal activation of the effector. |
| APIS315 |
SequestinF |
Thoeris |
CLAN001 |
|
PMID:41785351 |
Sequestin-family viral anti-defense protein; inhibits Thoeris by binding the TIR-produced ADPR-derived immune signal. |
| APIS356 |
SequestinI |
Thoeris |
CLAN001 |
|
PMID:41785351 |
Sequestin-family antidefense protein; neutralizes Thoeris signaling molecules and allows phage escape from Thoeris defense. |
| APIS372 |
SequestinC |
Thoeris |
CLAN001 |
|
PMID:41785351 |
Small phage anti-defense protein from the Sequestin family; inhibits type I Thoeris by interfering with 3′cADPR-mediated immune activation. |
| APIS373 |
SequestinG |
Thoeris |
CLAN001 |
|
PMID:41785351 |
Anti-Thoeris sponge protein; blocks Thoeris immune signaling, likely through sequestration of 3′cADPR. |
| APIS378 |
SequestinA |
Thoeris |
CLAN001 |
|
PMID:41785351 |
Phage-encoded anti-Thoeris sponge protein; binds/sequesters the type I Thoeris immune signal 3′cADPR, preventing activation of the ThsA NADase effector. |
| APIS203 |
|
|
CLAN001 |
|
|
|
| APIS205 |
|
|
CLAN001 |
|
|
|
| APIS221 |
|
|
CLAN001 |
|
|
|
| APIS227 |
|
|
CLAN001 |
|
|
|
| APIS230 |
|
|
CLAN001 |
|
|
|
| APIS247 |
|
|
CLAN001 |
|
|
|
| APIS252 |
|
|
CLAN001 |
|
|
|
| APIS254 |
|
|
CLAN001 |
|
|
|
| APIS256 |
|
|
CLAN001 |
|
|
|
| APIS268 |
|
|
CLAN001 |
|
|
|
| APIS271 |
|
|
CLAN001 |
|
|
|
| APIS280 |
|
|
CLAN001 |
|
|
|
| APIS302 |
|
|
CLAN001 |
|
|
|
| APIS306 |
|
|
CLAN001 |
|
|
|
| APIS310 |
|
|
CLAN001 |
|
|
|
| APIS318 |
|
|
CLAN001 |
|
|
|
| APIS323 |
|
|
CLAN001 |
|
|
|
| APIS327 |
|
|
CLAN001 |
|
|
|
| APIS331 |
|
|
CLAN001 |
|
|
|
| APIS332 |
|
|
CLAN001 |
|
|
|
| APIS333 |
|
|
CLAN001 |
|
|
|
| APIS334 |
|
|
CLAN001 |
|
|
|
| APIS341 |
|
|
CLAN001 |
|
|
|
| APIS344 |
|
|
CLAN001 |
|
|
|
| APIS353 |
|
|
CLAN001 |
|
|
|
| APIS360 |
|
|
CLAN001 |
|
|
|
| APIS362 |
|
|
CLAN001 |
|
|
|
| APIS371 |
|
|
CLAN001 |
|
|
|
| APIS374 |
|
|
CLAN001 |
|
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|
