y
Basic Information | |
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Species | Carica papaya |
Cazyme ID | evm.model.supercontig_375.4 |
Family | AA3 |
Protein Properties | Length: 356 Molecular Weight: 39200.1 Isoelectric Point: 5.7006 |
Chromosome | Chromosome/Scaffold: 375 Start: 35637 End: 36750 |
Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
AA3 | 21 | 354 | 5.7e-23 |
DEDFYQNSGFNWDLTVVNQSYQWVEGAIVFRPELRNWQSAVRDSLLEAGIDPYNGFNLDHVVGTKIGGSTFDSLGRRHSAVDLLSYAKASNIRVGIYASV ERVLLASSSTSSESRQSAIGLVYRDQMGGYHHAMVREHGEVILCAGAIGSPQLLLLSGIGPRPYRASWGIPVAYHHPYVGEYLYDNPRNVISILPSVPLE HSLIQVVGMTEMGAYIEASSSVIPFASSGSSAFAATSFSPLFLTVTTLIEKIVGPLIRFTQPGFDRLDVERHVNETRKTGDLLRSRSMEDFKLVNGEEDE ISGLLGIHTADQSDNAQMAGFRRQTVNTIWHYHG |
Full Sequence |
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Protein Sequence Length: 356 Download |
MIDALIVSND AQARDHYMMA DEDFYQNSGF NWDLTVVNQS YQWVEGAIVF RPELRNWQSA 60 VRDSLLEAGI DPYNGFNLDH VVGTKIGGST FDSLGRRHSA VDLLSYAKAS NIRVGIYASV 120 ERVLLASSST SSESRQSAIG LVYRDQMGGY HHAMVREHGE VILCAGAIGS PQLLLLSGIG 180 PRPYRASWGI PVAYHHPYVG EYLYDNPRNV ISILPSVPLE HSLIQVVGMT EMGAYIEASS 240 SVIPFASSGS SAFAATSFSP LFLTVTTLIE KIVGPLIRFT QPGFDRLDVE RHVNETRKTG 300 DLLRSRSMED FKLVNGEEDE ISGLLGIHTA DQSDNAQMAG FRRQTVNTIW HYHGL* 360 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam00732 | GMC_oxred_N | 3.0e-8 | 95 | 207 | 114 | + GMC oxidoreductase. This family of proteins bind FAD as a cofactor. | ||
TIGR01810 | betA | 5.0e-10 | 160 | 206 | 47 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
COG2303 | BetA | 2.0e-14 | 49 | 207 | 166 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
PRK02106 | PRK02106 | 5.0e-15 | 95 | 205 | 113 | + choline dehydrogenase; Validated | ||
PLN02785 | PLN02785 | 2.0e-80 | 17 | 354 | 397 | + Protein HOTHEAD |
Gene Ontology | |
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GO Term | Description |
GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
GO:0050660 | flavin adenine dinucleotide binding |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ABE65766.1 | 0 | 17 | 354 | 141 | 495 | mandelonitrile lyase [Arabidopsis thaliana] |
RefSeq | NP_177448.1 | 0 | 17 | 354 | 141 | 495 | (R)-mandelonitrile lyase, putative / (R)-oxynitrilase, putative [Arabidopsis thaliana] |
Swiss-Prot | P52706 | 0 | 17 | 354 | 141 | 489 | MDL1_PRUSE RecName: Full=(R)-mandelonitrile lyase 1; AltName: Full=Hydroxynitrile lyase 1; Short=(R)-oxynitrilase 1; Flags: Precursor |
RefSeq | XP_002277531.1 | 0 | 17 | 354 | 137 | 491 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002311915.1 | 0 | 17 | 354 | 107 | 462 | predicted protein [Populus trichocarpa] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3gdp_B | 0 | 17 | 354 | 114 | 462 | A Chain A, Crystal Structure Of E.Coli Gs Mutant Dmgs(C7s;c40 |
PDB | 3gdp_A | 0 | 17 | 354 | 114 | 462 | A Chain A, Crystal Structure Of E.Coli Gs Mutant Dmgs(C7s;c40 |
PDB | 3gdn_B | 0 | 17 | 354 | 114 | 462 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
PDB | 3gdn_A | 0 | 17 | 354 | 114 | 462 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
PDB | 1ju2_B | 0 | 17 | 354 | 114 | 462 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
Metabolic Pathways | |||
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Pathway Name | Reaction | EC | Protein Name |
amygdalin and prunasin degradation | MANDELONITRILE-LYASE-RXN | EC-4.1.2.10 | (R)-mandelonitrile lyase |
vicianin bioactivation | MANDELONITRILE-LYASE-RXN | EC-4.1.2.10 | (R)-mandelonitrile lyase |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
DT461593 | 154 | 91 | 244 | 0 |
GO514057 | 227 | 146 | 354 | 0 |
FD432556 | 213 | 32 | 244 | 0 |
CF487990 | 200 | 31 | 224 | 0 |
EE616486 | 223 | 17 | 238 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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