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Basic Information | |
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Species | Phaseolus vulgaris |
Cazyme ID | Phvul.001G165300.1 |
Family | GT47 |
Protein Properties | Length: 1215 Molecular Weight: 135828 Isoelectric Point: 9.2597 |
Chromosome | Chromosome/Scaffold: 01 Start: 42575971 End: 42585139 |
Description | Subtilase family protein |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 179 | 398 | 0 |
VDRPEWKIMNGRDHFLVAGRITWDFRRLTEDESDWGNKLLFLPAARNMSMLVVESSPWNANDFGIPYPTYFHPAKDDDVFIWQERMRRLERKWLFSFAGA PRPDNPKSIRGQIIEQCRGSRVGKLLECDFGESKCHSPSSIMQMFQGSLFCLQPQGDSYTRRSAFDSMLAGCIPVFFHPGSAYTQYTWHLPKNYTKYSVF IPEDDIRKRNVSIEERLRQI |
Full Sequence |
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Protein Sequence Length: 1215 Download |
GFDERPEFRR NRSPMRRRPV AGIFPEQMEK TTSRNPNSRL CFLALLSAFF WFLLLYFHFA 60 VLGNQSPKVS PLPITFQQPR KSLGSQTLTP IETPPTPSFP FARALRTALN KSDRCGGRYI 120 YVHDLPSRFN EDMLKKCRTL SLWTNMCKFT TNAGLGPPLE NVKGVFSDTG WYATNQFTVD 180 RPEWKIMNGR DHFLVAGRIT WDFRRLTEDE SDWGNKLLFL PAARNMSMLV VESSPWNAND 240 FGIPYPTYFH PAKDDDVFIW QERMRRLERK WLFSFAGAPR PDNPKSIRGQ IIEQCRGSRV 300 GKLLECDFGE SKCHSPSSIM QMFQGSLFCL QPQGDSYTRR SAFDSMLAGC IPVFFHPGSA 360 YTQYTWHLPK NYTKYSVFIP EDDIRKRNVS IEERLRQIPE EEVRIMREEV ISLIPRLVYA 420 DPRSKLETLR DAFDVSVQSV IDKVTNLRKD IMEGRTDDNF IEENSWKYAL LDEGQREVGP 480 HEWDPFFSKP KDGNGDSIQL HPHGTTSSAF TSKLKWHLSF IQQTLSSDED PSSRLLYSYR 540 SAMDGFAAQL SESEVEYLKN LPDVISIRPD RMLQIQTTYS YKFLGLNPAR ENGWYQSGFG 600 RGTIIGVLDT GVWPESPSFN DQGMPPVPKK WKGICQAGKA FNSSNCNRKL IGARYFTKGH 660 SSVSPFRIPE YLSPRDSSGH GTHTSSTAGG VPVPLASVFV CWFNGCYNSD IMAAMDVAIR 720 DGVDILSLSL GGFSTPLYDD SIAIGSFRAM EHGISVICAA GNNGPTAMSV ANEAPWIATI 780 GASTLDRTFP AIVHMGNGQR LYGESMYPLN HPMSKGKELE LVYLSEGDTE SQFCLRGSLP 840 RDKVKGKMVV CDRGVNGRAE KGQVVKEAGG VAMILTNTEI NLGEDSVDVH VLPASLVGFD 900 EAVTLKDYIN STRRPLARIE FGGTVIGKSR APAVARFSAR GPSYTNPSIL KPDVIAPGVN 960 IIAAWPQNLG PTGLPEDSRR VNFSVMSGTS MACPHVSGIA ALVRSAHPGW SPAAIKSAIM 1020 TTAEATDHTG RPILDESQPA GVFDMGAGHV NPQRALNPGL VYDIRPDDYI IHLCSLGYTR 1080 SEIFSITHRN VSCNAVMKMN RGFSLNYPSF SVIFKDGERR KMFRRRLTNV GSANSIYSVE 1140 VMAPEGVKVI VKPKRLVFKQ VNQSLTYRVW FISRKRVKRG DGLVTYAEGN LTWVHSQNGF 1200 NRVRSPVAVT WKSK* 1260 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd07474 | Peptidases_S8_subtilisin_Vpr-like | 2.0e-30 | 919 | 1055 | 138 | + Peptidase S8 family domain in Vpr-like proteins. The maturation of the peptide antibiotic (lantibiotic) subtilin in Bacillus subtilis ATCC 6633 includes posttranslational modifications of the propeptide and proteolytic cleavage of the leader peptide. Vpr was identified as one of the proteases, along with WprA, that are capable of processing subtilin. Asp, Ser, His triadPeptidases S8 or Subtilases are a serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. | ||
cd02120 | PA_subtilisin_like | 3.0e-34 | 793 | 919 | 128 | + PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from Alnus glutinosa ag12, members of the tomato P69 family, and tomato LeSBT2. These proteins belong to the peptidase S8 family. Cucumisin from the juice of melon fruits is a thermostable serine peptidase, with a broad substrate specificity for oligopeptides and proteins. A. thaliana Ara12 is a thermostable, extracellular serine protease, found chiefly in silique tissue and stem tissue. Ara12 is stimulated by Ca2+ ions. A. glutinosa ag12 is expressed at high levels in the nodules, and at low levels in the shoot tips; it is implicated in both symbiotic and non-symbiotic processes in plant development. The tomato P69 protease family is comprised of various protein isoforms of approximately 69KDa. These isoforms accumulate extracellularly. Some of the P69 genes are tightly regulated in a tissue specific fashion, and by environmental and developmental signals. For example: infection with avirulent bacteria activates transcription of the genes for the P69 B and C isoforms, the P69 E transcript was detected only in roots, and the P69F transcript only in hydathodes. The Tomato LeSBT2 subtilase transcript was not detected in flowers and roots, but was present in cotyledons and leaves. The significance of the PA domain to these proteins has not been ascertained. It may be a protein-protein interaction domain. At peptidase active sites, the PA domain may participate in substrate binding and/or promoting conformational changes, which influence the stability and accessibility of the site to substrate. | ||
cd04852 | Peptidases_S8_3 | 2.0e-36 | 948 | 1023 | 76 | + Peptidase S8 family domain, uncharacterized subfamily 3. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. | ||
pfam03016 | Exostosin | 3.0e-49 | 114 | 398 | 331 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
cd04852 | Peptidases_S8_3 | 5.0e-83 | 573 | 785 | 236 | + Peptidase S8 family domain, uncharacterized subfamily 3. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. |
Gene Ontology | |
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GO Term | Description |
GO:0004252 | serine-type endopeptidase activity |
GO:0006508 | proteolysis |
GO:0016020 | membrane |
GO:0042802 | identical protein binding |
GO:0043086 | negative regulation of catalytic activity |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI37197.1 | 0 | 15 | 1211 | 54 | 1316 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_563701.1 | 0 | 498 | 1213 | 30 | 774 | SDD1 (STOMATAL DENSITY AND DISTRIBUTION); serine-type endopeptidase [Arabidopsis thaliana] |
RefSeq | XP_002269766.1 | 0 | 15 | 1211 | 59 | 1411 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002301847.1 | 0 | 543 | 1212 | 1 | 692 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002526537.1 | 0 | 498 | 1214 | 30 | 769 | Cucumisin precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3i74_B | 0 | 577 | 1210 | 1 | 643 | C Chain C, Crystal Structure Of The Plant Subtilisin-Like Protease Sbt3 In Complex With A Chloromethylketone Inhibitor |
PDB | 3i74_A | 0 | 577 | 1210 | 1 | 643 | C Chain C, Crystal Structure Of The Plant Subtilisin-Like Protease Sbt3 In Complex With A Chloromethylketone Inhibitor |
PDB | 3i6s_B | 0 | 577 | 1210 | 1 | 643 | A Chain A, Crystal Structure Of The Plant Subtilisin-Like Protease Sbt3 |
PDB | 3i6s_A | 0 | 577 | 1210 | 1 | 643 | A Chain A, Crystal Structure Of The Plant Subtilisin-Like Protease Sbt3 |
PDB | 3vta_B | 0 | 577 | 1210 | 1 | 618 | A Chain A, Crystal Structure Of Cucumisin, A Subtilisin-Like Endoprotease From Cucumis Melo L |