y
Basic Information | |
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Species | Fragaria vesca |
Cazyme ID | mrna11600.1-v1.0-hybrid |
Family | GH79 |
Protein Properties | Length: 322 Molecular Weight: 35080.9 Isoelectric Point: 6.499 |
Chromosome | Chromosome/Scaffold: Start: 9145418 End: 9148303 |
Description | glucuronidase 3 |
View CDS |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 68 | 314 | 0 |
TCSATDLVDKILNPSVLDGISKTFSDLQMLVKSSHTSAVAWVGESGGAYNSGHNLVTSAFVFSFWYLDQLGMSASYDTKTYCRQTLIGGNYGLLDINTFK PNPDYYSALLWQRLMGNNVLSTSFSGTKKLRTYAHCSKKTQGITVLLINLGNTTVQVDVSTKNGGSRSTLNFKEGLKDSKATKNDVREEYHITAKDGDLL SRVILLNGKELTVNSAGQIPSLEPMIVEISDPTSVAPFSIVFVHIPN |
Full Sequence |
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Protein Sequence Length: 322 Download |
MRSLVLLFFV FCWLYEVTHC RNSISVASQS TAADTVFVNG TAAIGSIDDD FVCATLDWWP 60 PEKCDYGTCS ATDLVDKILN PSVLDGISKT FSDLQMLVKS SHTSAVAWVG ESGGAYNSGH 120 NLVTSAFVFS FWYLDQLGMS ASYDTKTYCR QTLIGGNYGL LDINTFKPNP DYYSALLWQR 180 LMGNNVLSTS FSGTKKLRTY AHCSKKTQGI TVLLINLGNT TVQVDVSTKN GGSRSTLNFK 240 EGLKDSKATK NDVREEYHIT AKDGDLLSRV ILLNGKELTV NSAGQIPSLE PMIVEISDPT 300 SVAPFSIVFV HIPNITVPAC K* 360 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 9.0e-17 | 35 | 96 | 69 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
pfam03662 | Glyco_hydro_79n | 1.0e-30 | 72 | 138 | 67 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |