y
Basic Information | |
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Species | Linum usitatissimum |
Cazyme ID | Lus10037110 |
Family | GH79 |
Protein Properties | Length: 522 Molecular Weight: 57777.6 Isoelectric Point: 8.6283 |
Chromosome | Chromosome/Scaffold: 462 Start: 254697 End: 256854 |
Description | glucuronidase 2 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 43 | 516 | 0 |
SDFICATLDWWPKNKCDYNQCPWGQTSALNLDLNNTNLATAIKAFDPLRIRVGGSLEDLVVYKVGKAIKRFPKFKKLKGGMFGFSRGTLTMDRWDQLNQL FTKTNTKVIFGLNALVGKRRKDESSTLWIGDWNPQNARDFMNYTVQKGYKIDSYELGNELSGSGVSARVEPEQYAKDTIKVRKAVNELYPDPNSRPLVLG PAGFFDKEWFKKYLQAVGPNVVDGVTHHIYNLGAGVDSNLINKVQDPFFLDKVAQTFKDVKDVVEQSGTPAAPWVGESGGAFNSGGKDVSNTFANGFWYL DQLGMTSTFGYKAYCRQSLVGGNYGLLRSDTFTPNPDYYGALLWHRLMGTGVLRTIHDESPYLRAYSHCSKKNSGVTLLLINMSNSTTFNIWVNNDLNLY RKTADSATLTEDREEYHLTSEGGNIQSDVVLLNGIPLKLKSCGEIPKMDPKLVPSSSPVSVAPDSFAYVNIKDF |
Full Sequence |
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Protein Sequence Length: 522 Download |
MAAFRAFLVY SLLLSTLSAL CFSDTSSITV TVQSVTTIAK TDSDFICATL DWWPKNKCDY 60 NQCPWGQTSA LNLDLNNTNL ATAIKAFDPL RIRVGGSLED LVVYKVGKAI KRFPKFKKLK 120 GGMFGFSRGT LTMDRWDQLN QLFTKTNTKV IFGLNALVGK RRKDESSTLW IGDWNPQNAR 180 DFMNYTVQKG YKIDSYELGN ELSGSGVSAR VEPEQYAKDT IKVRKAVNEL YPDPNSRPLV 240 LGPAGFFDKE WFKKYLQAVG PNVVDGVTHH IYNLGAGVDS NLINKVQDPF FLDKVAQTFK 300 DVKDVVEQSG TPAAPWVGES GGAFNSGGKD VSNTFANGFW YLDQLGMTST FGYKAYCRQS 360 LVGGNYGLLR SDTFTPNPDY YGALLWHRLM GTGVLRTIHD ESPYLRAYSH CSKKNSGVTL 420 LLINMSNSTT FNIWVNNDLN LYRKTADSAT LTEDREEYHL TSEGGNIQSD VVLLNGIPLK 480 LKSCGEIPKM DPKLVPSSSP VSVAPDSFAY VNIKDFKAPA C* 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 2.0e-151 | 39 | 346 | 308 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 28 | 521 | 27 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 28 | 521 | 25 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 1 | 521 | 1 | 517 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0.000000001 | 8 | 103 | 490 | 587 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0 | 28 | 520 | 31 | 529 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0000006 | 122 | 409 | 107 | 383 | A Chain A, Crystal Structure Of Curcuminoid Synthase Cus From Oryza Sativa |
PDB | 3vnz_A | 0.0000006 | 122 | 409 | 107 | 383 | A Chain A, Crystal Structure Of Curcuminoid Synthase Cus From Oryza Sativa |
PDB | 3vny_A | 0.0000006 | 122 | 409 | 107 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |