y
Basic Information | |
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Species | Brachypodium distachyon |
Cazyme ID | Bradi4g03680.1 |
Family | GH79 |
Protein Properties | Length: 539 Molecular Weight: 59003.9 Isoelectric Point: 5.4661 |
Chromosome | Chromosome/Scaffold: 4 Start: 2927621 End: 2931745 |
Description | glucuronidase 1 |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 39 | 532 | 0 |
SDEFICATIDWWPPEKCNYDQCPWGKASVLNMDLTNPLLAKAIQAFSPLRIRVGGSLQDQVVYGTPNLGSPCRAFTKSSSGLFGFSKGCITMERWDAIND LFLNTGAVITFGLNALQGRKQIRKGVWGGAWNSSNAQEFMEYTASMNYPIDSWEFGNELSGSGIGASVGAEQYGKDLVELQKMVNQLYGNSRKPLVLAPG GFYDKQWFAQLLEVSGPNVLKGMTHHIYNLGAGNDPRVANRILDPQYLSRVSDTFRDLQLTIQRHGPWSAPWVGEAGGAYNSGSRTVSNTFLNSFWYLDQ LGQSAKYDTKVYCRQTLIGGNYGLLDTDTFVPNPDYYSALLWHRLMGKGVLSMDIGGSSYLRAYAHCGKQKGGVTLLLINLSQNMGSMVSVRNDLNVDLA QGQGITRDNSFVHGLKRTVSWVGSKASDGLEKREEYHLTAQDGDPLTRTVLLNGVPLELTADGDIPPLYPVQVSVSSPIYVSPLSIAFVVFPDF |
Full Sequence |
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Protein Sequence Length: 539 Download |
MGLWSLLPLL LCLPTLILSE DYSDVTVIIR GSETIAATSD EFICATIDWW PPEKCNYDQC 60 PWGKASVLNM DLTNPLLAKA IQAFSPLRIR VGGSLQDQVV YGTPNLGSPC RAFTKSSSGL 120 FGFSKGCITM ERWDAINDLF LNTGAVITFG LNALQGRKQI RKGVWGGAWN SSNAQEFMEY 180 TASMNYPIDS WEFGNELSGS GIGASVGAEQ YGKDLVELQK MVNQLYGNSR KPLVLAPGGF 240 YDKQWFAQLL EVSGPNVLKG MTHHIYNLGA GNDPRVANRI LDPQYLSRVS DTFRDLQLTI 300 QRHGPWSAPW VGEAGGAYNS GSRTVSNTFL NSFWYLDQLG QSAKYDTKVY CRQTLIGGNY 360 GLLDTDTFVP NPDYYSALLW HRLMGKGVLS MDIGGSSYLR AYAHCGKQKG GVTLLLINLS 420 QNMGSMVSVR NDLNVDLAQG QGITRDNSFV HGLKRTVSWV GSKASDGLEK REEYHLTAQD 480 GDPLTRTVLL NGVPLELTAD GDIPPLYPVQ VSVSSPIYVS PLSIAFVVFP DFEADACQ* 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 24 | 340 | 318 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ACR10240.1 | 0 | 1 | 538 | 1 | 538 | heparanase [Oryza sativa Indica Group] |
EMBL | CAD42650.1 | 0 | 17 | 537 | 17 | 537 | putative heparanase [Hordeum vulgare subsp. vulgare] |
GenBank | EEC69565.1 | 0 | 1 | 538 | 671 | 1236 | hypothetical protein OsI_38868 [Oryza sativa Indica Group] |
GenBank | EEE53489.1 | 0 | 1 | 538 | 1 | 566 | hypothetical protein OsJ_36644 [Oryza sativa Japonica Group] |
RefSeq | NP_001067122.1 | 0 | 1 | 538 | 1 | 538 | Os12g0578400 [Oryza sativa (japonica cultivar-group)] |