y
Basic Information | |
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Species | Linum usitatissimum |
Cazyme ID | Lus10034707 |
Family | GH79 |
Protein Properties | Length: 519 Molecular Weight: 57419.3 Isoelectric Point: 9.53 |
Chromosome | Chromosome/Scaffold: 9 Start: 1526649 End: 1529699 |
Description | glucuronidase 2 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 17 | 512 | 0 |
DDNYVCATLDWWPHDKCDYNHCPWGYTSAVNLDVSHPVLGKAIQAFSPLRIRIGGSLQDQVLYDVGNLGSNCHSFFKMKWGLFGFSKGCLHMDRWDSLNN LFSRTGAMVTFGLNALRGRHKTWGKHWGGSWNSTNTYDLISYTISKGHKIDSWEYGNELSGTGIGASVSVDTYAKDVIKLREIVDTLYKNSKRKPSVIAP GGFFEKDWYAKLLKITGPGTINVVTHHIYNLGAGVDPHLIQHIMDPNYLSKVSRTFGNLSQTIKQNGPWASAWVGESGGAYNSGGFHISDTFVNSFWYLD QLGLAATYNTKVYCRQTLVGGHYSLLNITTFVPNPDYYSALLWHRLMGKTVLGVTSTASPYLRYYAHCSRGRQGITVLLINLSNSTRFIVNIRSSSSLAL NLQAREPGIKSSFIDSLKRSVSWIGSKATEGSLFREEYHLSPKDGNLRSKTMLLNGNPIQLTEKGDIPKLEPVRYRLSSPLYISSSSISFIVLPNF |
Full Sequence |
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Protein Sequence Length: 519 Download |
MTATVVVNGA TKVAETDDNY VCATLDWWPH DKCDYNHCPW GYTSAVNLDV SHPVLGKAIQ 60 AFSPLRIRIG GSLQDQVLYD VGNLGSNCHS FFKMKWGLFG FSKGCLHMDR WDSLNNLFSR 120 TGAMVTFGLN ALRGRHKTWG KHWGGSWNST NTYDLISYTI SKGHKIDSWE YGNELSGTGI 180 GASVSVDTYA KDVIKLREIV DTLYKNSKRK PSVIAPGGFF EKDWYAKLLK ITGPGTINVV 240 THHIYNLGAG VDPHLIQHIM DPNYLSKVSR TFGNLSQTIK QNGPWASAWV GESGGAYNSG 300 GFHISDTFVN SFWYLDQLGL AATYNTKVYC RQTLVGGHYS LLNITTFVPN PDYYSALLWH 360 RLMGKTVLGV TSTASPYLRY YAHCSRGRQG ITVLLINLSN STRFIVNIRS SSSLALNLQA 420 REPGIKSSFI DSLKRSVSWI GSKATEGSLF REEYHLSPKD GNLRSKTMLL NGNPIQLTEK 480 GDIPKLEPVR YRLSSPLYIS SSSISFIVLP NFGAPACA* 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 3 | 319 | 317 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
DDBJ | BAB08480.1 | 0 | 4 | 518 | 5 | 516 | unnamed protein product [Arabidopsis thaliana] |
EMBL | CAB62595.1 | 0 | 3 | 518 | 8 | 521 | putative protein [Arabidopsis thaliana] |
RefSeq | NP_196400.2 | 0 | 3 | 518 | 30 | 543 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
RefSeq | XP_002284470.1 | 0 | 3 | 518 | 25 | 539 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002514696.1 | 0 | 3 | 518 | 25 | 539 | Heparanase-2, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0003 | 237 | 420 | 235 | 423 | X Chain X, Crystal Structure Of The Full-Length Autotransporter Esta From Pseudomonas Aeruginosa |
PDB | 3vnz_A | 0.0003 | 237 | 420 | 235 | 423 | X Chain X, Crystal Structure Of The Full-Length Autotransporter Esta From Pseudomonas Aeruginosa |
PDB | 3vny_A | 0.0003 | 237 | 420 | 235 | 423 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
HO797031 | 371 | 150 | 518 | 0 |
CK266509 | 316 | 57 | 372 | 0 |
EC920863 | 287 | 46 | 332 | 0 |
GO873410 | 321 | 15 | 335 | 0 |
CO121889 | 301 | 179 | 478 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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