y
Basic Information | |
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Species | Arabidopsis thaliana |
Cazyme ID | AT5G34940.2 |
Family | GH79 |
Protein Properties | Length: 537 Molecular Weight: 59709.1 Isoelectric Point: 8.0377 |
Chromosome | Chromosome/Scaffold: 5 Start: 13235829 End: 13238839 |
Description | heparanase-like protein precursor, putative, expressed |
View CDS |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 45 | 530 | 0 |
DEDFICATLDWWPPEKCDYGSCSWDHASILNLDLNNVILQNAIKAFAPLKIRIGGTLQDIVIYETPDSKQPCLPFTKNSSILFGYTQGCLPMRRWDELNA FFRKTGTKVIFGLNALSGRSIKSNGEAIGAWNYTNAESFIRFTAENNYTIDGWELGNELCGSGVGARVGANQYAIDTINLRNIVNRVYKNVSPMPLVIGP GGFFEVDWFTEYLNKAENSLNATTRHIYDLGPGVDEHLIEKILNPSYLDQEAKSFRSLKNIIKNSSTKAVAWVGESGGAYNSGRNLVSNAFVYSFWYLDQ LGMASLYDTKTYCRQSLIGGNYGLLNTTNFTPNPDYYSALIWRQLMGRKALFTTFSGTKKIRSYTHCARQSKGITVLLMNLDNTTTVVAKVELNNSFSLR HTKHMKSYKRASSQLFGGPNGVIQREEYHLTAKDGNLHSQTMLLNGNALQVNSMGDLPPIEPIHINSTEPITIAPYSIVFVHMRNV |
Full Sequence |
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Protein Sequence Length: 537 Download |
MAYRQILAIV LFLCVFQFLD CTVSSAVEEN GTVFVYGRAA VGTIDEDFIC ATLDWWPPEK 60 CDYGSCSWDH ASILNLDLNN VILQNAIKAF APLKIRIGGT LQDIVIYETP DSKQPCLPFT 120 KNSSILFGYT QGCLPMRRWD ELNAFFRKTG TKVIFGLNAL SGRSIKSNGE AIGAWNYTNA 180 ESFIRFTAEN NYTIDGWELG NELCGSGVGA RVGANQYAID TINLRNIVNR VYKNVSPMPL 240 VIGPGGFFEV DWFTEYLNKA ENSLNATTRH IYDLGPGVDE HLIEKILNPS YLDQEAKSFR 300 SLKNIIKNSS TKAVAWVGES GGAYNSGRNL VSNAFVYSFW YLDQLGMASL YDTKTYCRQS 360 LIGGNYGLLN TTNFTPNPDY YSALIWRQLM GRKALFTTFS GTKKIRSYTH CARQSKGITV 420 LLMNLDNTTT VVAKVELNNS FSLRHTKHMK SYKRASSQLF GGPNGVIQRE EYHLTAKDGN 480 LHSQTMLLNG NALQVNSMGD LPPIEPIHIN STEPITIAPY SIVFVHMRNV VVPACA* 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 28 | 346 | 320 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0004566 | beta-glucuronidase activity |
GO:0008150 | biological_process |
GO:0009505 | plant-type cell wall |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
DDBJ | BAB10787.1 | 0 | 1 | 536 | 1 | 536 | unnamed protein product [Arabidopsis thaliana] |
RefSeq | NP_198344.2 | 0 | 1 | 381 | 1 | 381 | AtGUS3 (Arabidopsis thaliana glucuronidase 3); beta-glucuronidase |
RefSeq | NP_851092.1 | 0 | 136 | 536 | 1 | 401 | AtGUS3 (Arabidopsis thaliana glucuronidase 3); beta-glucuronidase |
RefSeq | NP_851093.1 | 0 | 1 | 536 | 1 | 536 | AtGUS3 (Arabidopsis thaliana glucuronidase 3); beta-glucuronidase |
RefSeq | XP_002324603.1 | 0 | 31 | 536 | 1 | 506 | predicted protein [Populus trichocarpa] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0000002 | 142 | 393 | 124 | 369 | A Chain A, Arabidopsis Thaliana Peroxidase A2 |
PDB | 3vnz_A | 0.0000002 | 142 | 393 | 124 | 369 | A Chain A, Arabidopsis Thaliana Peroxidase A2 |
PDB | 3vny_A | 0.0000002 | 142 | 393 | 124 | 369 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |