| APIS010 |
Ocr |
restriction-modification (RM);bacteriophage exclusion (BREX) |
CLAN017 |
T7 of E. coli |
PMID:32338761 329108 12235377 11804597 |
Ocr physically associates with BrxX methyltransferase to neutralizes their ability to both methylate and exclude incoming phage DNA. Ocr structurally mimics the DNA phosphate backbone and interacts directly with EcoKI (both the MTase and REase domain of this type I R–M enzyme), thereby interfering with the activity of this system. |
| APIS077 |
|
|
CLAN017 |
Proteus phage PM 116 |
|
|
| APIS085 |
|
|
CLAN017 |
Escherichia phage T7 |
|
|
| APIS087 |
|
|
CLAN017 |
Shigella phage ESh23 |
|
|
| APIS276 |
T7K |
Retron-Eco9,DarTG1 |
CLAN017 |
Escherichia phage T7 |
Bartolec et al., 2024 |
The T7 kinase weakens the activity of phage defense systems by phosphorylation, and is likely a broadly-acting phage counter-defense system. |
| APIS276 |
jss1_004 |
Dnd,QatABCD,SIR2+HerA,DUF4297+HerA,CRISPR‒Cas |
CLAN017 |
Salmonella phage JSS1 |
PMID:39506096 |
JSS1_004 employs N-terminal Ser/Thr/Tyr protein kinase activity to catalyse the multisite phosphorylation of host DndFGH. It also phosphorylates other bacterial immune systems to varying degrees, including CRISPR‒Cas, QatABCD, SIR2+HerA and DUF4297+HerA. |
| APIS357 |
|
|
CLAN017 |
|
|
|
