y
Basic Information | |
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Species | Physcomitrella patens |
Cazyme ID | Pp1s6_50V6.1 |
Family | GH31 |
Protein Properties | Length: 916 Molecular Weight: 102477 Isoelectric Point: 5.4855 |
Chromosome | Chromosome/Scaffold: 6 Start: 637777 End: 642025 |
Description | alpha-xylosidase 1 |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH31 | 266 | 756 | 0 |
FYFFSGPAPIAVVDQYTQLVGRPAAMPYWVLGFHQSRYGYNNVEQLDYVMKKYAEVNLPVESMWSDIDHMDHYKDFTLDPVNYPVDKLLPFVQNLHKNHQ KFIMILDPGIKIDTNYSTYVRGDKLDIFMRNGTSHRYVAQVWPGATNIPDFLHPKSQEFWSTEVAEFHKVIPFDGLWLDMNEPANFCGGPTCYFPPGIQT CPQIDECCMICDNTNLNRWDDPPYHINSLGIHRPLYAHTMAMNCEHFNGIRAYDTHNVYGMSEGLATYRALKELTGKRPFVLARSMFLGSGSYAAHWTGD NGATWGDLQYSVVSIINLGLFGVPMVGADICGFNFQTNEELCIRWTQVGAFYPFSRDHSDIHAGPQEFYLWESVTETARSVFSWRYRLLPFLYTLMFGAH KTGAPIFRPLFFAVPEDSRTWDIADQFTLGTDLLVSPVLQQGQVTVNAYFPQGVWYNLFNPSQVVRANNSFHTLDAPLDTINAHVRSGSIL |
Full Sequence |
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Protein Sequence Length: 916 Download |
MGRQGSMALL AFTLFGLLSS VKADSIGYGY NLVGLDDLNN GGGVVGYLEL VKATETYGAD 60 VKNLKLVARY RGSDRLQVHI SDADSKRYEV PQELLPRDPV DSFKANRKLF GRLKVEKSGV 120 ISSKKNQLEF HYVAEPFGFA VVRRSNGEVL WNTSAPGSGL FNNIIFKDQY LEISSQLPYK 180 SALYGLGESS RPDGLRLSHN RQYTMWATDI GSWNIDIDLY GVFPFLVDVR EGGLTHGVAI 240 MNSNGMDIVY NDTSITFKII GGVFDFYFFS GPAPIAVVDQ YTQLVGRPAA MPYWVLGFHQ 300 SRYGYNNVEQ LDYVMKKYAE VNLPVESMWS DIDHMDHYKD FTLDPVNYPV DKLLPFVQNL 360 HKNHQKFIMI LDPGIKIDTN YSTYVRGDKL DIFMRNGTSH RYVAQVWPGA TNIPDFLHPK 420 SQEFWSTEVA EFHKVIPFDG LWLDMNEPAN FCGGPTCYFP PGIQTCPQID ECCMICDNTN 480 LNRWDDPPYH INSLGIHRPL YAHTMAMNCE HFNGIRAYDT HNVYGMSEGL ATYRALKELT 540 GKRPFVLARS MFLGSGSYAA HWTGDNGATW GDLQYSVVSI INLGLFGVPM VGADICGFNF 600 QTNEELCIRW TQVGAFYPFS RDHSDIHAGP QEFYLWESVT ETARSVFSWR YRLLPFLYTL 660 MFGAHKTGAP IFRPLFFAVP EDSRTWDIAD QFTLGTDLLV SPVLQQGQVT VNAYFPQGVW 720 YNLFNPSQVV RANNSFHTLD APLDTINAHV RSGSILPLQD LAPTTTQARK TPYTLLIAMD 780 PESDSFNAPS AICDRRSKAT GELFIDDDDT ISMQVKDGAG SLVTFEATRK DGVYVLKADV 840 EEGAYAVKQG LMLQTVSVLG VRTAPNSVKV NGKYEAVNVT FDNKASYLTL TDLNLPIGKD 900 FEVSWDCSGS DAFTS* 960 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd06603 | GH31_GANC_GANAB_alpha | 2.0e-88 | 286 | 668 | 388 | + This family includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in electrophoretic mobility in starch gel, GANC and GANAB have been shown to have other differences, including those of substrate specificity. GANC and GANAB are key enzymes in glycogen metabolism that hydrolyze terminal, non-reducing 1,4-linked alpha-D-glucose residues from glycogen in the endoplasmic reticulum. The GANC/GANAB family includes the alpha-glucosidase II (ModA) from Dictyostelium discoideum as well as the alpha-glucosidase II (GLS2, or ROT2 - Reversal of TOR2 lethality protein 2) from Saccharomyces cerevisiae. | ||
cd06604 | GH31_glucosidase_II_MalA | 5.0e-100 | 286 | 668 | 385 | + Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This family also includes the MalA alpha-glucosidase from Sulfolobus sulfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source. | ||
COG1501 | COG1501 | 2.0e-123 | 146 | 760 | 627 | + Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism] | ||
pfam01055 | Glyco_hydro_31 | 8.0e-176 | 267 | 756 | 495 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. | ||
cd06602 | GH31_MGAM_SI_GAA | 5.0e-180 | 286 | 686 | 405 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). |
Gene Ontology | |
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GO Term | Description |
GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
GO:0005975 | carbohydrate metabolic process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | XP_001752856.1 | 0 | 7 | 915 | 1 | 909 | predicted protein [Physcomitrella patens subsp. patens] |
RefSeq | XP_001756901.1 | 0 | 6 | 905 | 9 | 906 | predicted protein [Physcomitrella patens subsp. patens] |
RefSeq | XP_001765995.1 | 0 | 8 | 915 | 10 | 928 | predicted protein [Physcomitrella patens subsp. patens] |
RefSeq | XP_001773000.1 | 0 | 10 | 905 | 22 | 923 | predicted protein [Physcomitrella patens subsp. patens] |
RefSeq | XP_001779762.1 | 0 | 29 | 906 | 19 | 898 | predicted protein [Physcomitrella patens subsp. patens] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3w38_A | 0 | 22 | 910 | 37 | 911 | A Chain A, Crystal Structure Of Galactose Oxidase Mutant W290f |
PDB | 3w37_A | 0 | 22 | 910 | 37 | 911 | A Chain A, Crystal Structure Of Galactose Oxidase Mutant W290f |
PDB | 3ctt_A | 0 | 25 | 905 | 47 | 868 | A Chain A, Crystal Structure Of Galactose Oxidase Mutant W290f |
PDB | 2qmj_A | 0 | 25 | 905 | 47 | 868 | A Chain A, Crystal Structure Of Galactose Oxidase Mutant W290f |
PDB | 2qly_A | 0 | 25 | 905 | 47 | 868 | A Chain A, Crystral Structure Of The N-Terminal Subunit Of Human Maltase- Glucoamylase |
Metabolic Pathways | |||
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Pathway Name | Reaction | EC | Protein Name |
starch degradation I | RXN-2141 | EC-3.2.1.20 | α-glucosidase |