y
Basic Information | |
---|---|
Species | Brassica rapa |
Cazyme ID | Bra004031 |
Family | GH31 |
Protein Properties | Length: 925 Molecular Weight: 102993 Isoelectric Point: 8.4829 |
Chromosome | Chromosome/Scaffold: 07 Start: 16408970 End: 16412745 |
Description | alpha-xylosidase 1 |
View CDS |
External Links |
---|
NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
GH31 | 266 | 758 | 0 |
FYFVAGPSPLDVVDQYTSLIGRPAPMPYWSLGFHQCRWGYHNLSVVEDVVDSYKKAKIPLDVIWNDDDHMDAHKDFTLNNISYPRAKLLKFLDRIHKMGM KYIVINDPGIGVNASYGVYQRAMANDVFIKYEGKPFLAQVWPGPVYFPDFLNPKTVAWWGDEIRRFHELVPIDGLWIDMNEVSNFCSGLCTIPKGKQCPS GEGPGWICCLDCKNITKTRWDDPPYKINATGVTAPVGFKTIATSALHYNGVREYDAHSLYGFSETIATHKGLQSIQGKRPFILSRSTFVGSGRYAAHWTG DNKGTWQSLRVSISTMLNFGIFGVPMVGSDICGFYPQPTEELCNRWIEVGAFYPFSRDHANYYSPRQELYQWDTVAKSARNALGMRYKLLPYLYTLSYEA HMTGAPMARPLFFSFPEYTKCYGLSTQFLLGTSLMISPVLKKGRTQVKALFPPGSWYHMFDMTQAVVTKTGKRVALPAPLHFVNVHLYQNTIL |
Full Sequence |
---|
Protein Sequence Length: 925 Download |
MASPKTAVSS LSLLVALIIC FSPVHSSNTI GKGYRLISVE ESPDGGFIGY LQVKQKTNIY 60 GSDITTLRLF VKHETDNRLR VHITDARKQR WEVPYNLLPR EQPPPAGKVI GKSPTTVHEI 120 SGSELIFSFT KDPFTFAVKR KSNGQTLFNT SSDSASPFGQ MVFKDQYLEI STSLPKDASL 180 YGLGENSQAK GIKLVPNEPY TLYTEDVSAI NLNTDLYGSH PVYMDLRNVG GKPYAHAVLL 240 LNSNGMDVFY RGTSLTYKVT GGVFDFYFVA GPSPLDVVDQ YTSLIGRPAP MPYWSLGFHQ 300 CRWGYHNLSV VEDVVDSYKK AKIPLDVIWN DDDHMDAHKD FTLNNISYPR AKLLKFLDRI 360 HKMGMKYIVI NDPGIGVNAS YGVYQRAMAN DVFIKYEGKP FLAQVWPGPV YFPDFLNPKT 420 VAWWGDEIRR FHELVPIDGL WIDMNEVSNF CSGLCTIPKG KQCPSGEGPG WICCLDCKNI 480 TKTRWDDPPY KINATGVTAP VGFKTIATSA LHYNGVREYD AHSLYGFSET IATHKGLQSI 540 QGKRPFILSR STFVGSGRYA AHWTGDNKGT WQSLRVSIST MLNFGIFGVP MVGSDICGFY 600 PQPTEELCNR WIEVGAFYPF SRDHANYYSP RQELYQWDTV AKSARNALGM RYKLLPYLYT 660 LSYEAHMTGA PMARPLFFSF PEYTKCYGLS TQFLLGTSLM ISPVLKKGRT QVKALFPPGS 720 WYHMFDMTQA VVTKTGKRVA LPAPLHFVNV HLYQNTILPM QQGGLISKEA RTTPFSLVIT 780 FPAGATEGYA TGKLYLDEDE LPEMKLGNGQ STYVDFYASV GNGTVKMWSQ VKEGKFALSK 840 GWVIEKVSVL GLKGAGSASE IEINGSPISN EAKKIEVSSK EHTYVVGLEE EGENKSVMVE 900 VKGLEMMVGK DFNMSWKMGI NGAN* 960 |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam01055 | Glyco_hydro_31 | 4.0e-85 | 267 | 453 | 187 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. | ||
cd06602 | GH31_MGAM_SI_GAA | 2.0e-92 | 519 | 682 | 165 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
cd06603 | GH31_GANC_GANAB_alpha | 1.0e-98 | 286 | 669 | 391 | + This family includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in electrophoretic mobility in starch gel, GANC and GANAB have been shown to have other differences, including those of substrate specificity. GANC and GANAB are key enzymes in glycogen metabolism that hydrolyze terminal, non-reducing 1,4-linked alpha-D-glucose residues from glycogen in the endoplasmic reticulum. The GANC/GANAB family includes the alpha-glucosidase II (ModA) from Dictyostelium discoideum as well as the alpha-glucosidase II (GLS2, or ROT2 - Reversal of TOR2 lethality protein 2) from Saccharomyces cerevisiae. | ||
pfam01055 | Glyco_hydro_31 | 5.0e-107 | 511 | 758 | 252 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. | ||
cd06604 | GH31_glucosidase_II_MalA | 1.0e-117 | 286 | 669 | 390 | + Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This family also includes the MalA alpha-glucosidase from Sulfolobus sulfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
GO:0005975 | carbohydrate metabolic process |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAD05539.1 | 0 | 20 | 921 | 13 | 907 | alpha-xylosidase precursor [Arabidopsis thaliana] |
RefSeq | NP_177023.1 | 0 | 20 | 921 | 21 | 915 | XYL1 (ALPHA-XYLOSIDASE 1); alpha-N-arabinofuranosidase/ hydrolase, hydrolyzing O-glycosyl compounds / xylan 1,4-beta-xylosidase [Arabidopsis thaliana] |
RefSeq | XP_002311455.1 | 0 | 22 | 922 | 4 | 910 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002315944.1 | 0 | 20 | 922 | 19 | 928 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002531635.1 | 0 | 12 | 922 | 10 | 930 | alpha-glucosidase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3w38_A | 0 | 4 | 914 | 7 | 904 | A Chain A, Crystal Structure Of A Beta-Galactosidase From Bacteroides Thetaiotaomicron |
PDB | 3w37_A | 0 | 4 | 914 | 7 | 904 | A Chain A, Crystal Structure Of A Beta-Galactosidase From Bacteroides Thetaiotaomicron |
PDB | 3lpp_D | 0 | 59 | 916 | 105 | 898 | A Chain A, Crystal Structure Of A Beta-Galactosidase From Bacteroides Thetaiotaomicron |
PDB | 3lpp_C | 0 | 59 | 916 | 105 | 898 | A Chain A, Crystal Structure Of A Beta-Galactosidase From Bacteroides Thetaiotaomicron |
PDB | 3lpp_B | 0 | 59 | 916 | 105 | 898 | A Chain A, Crystal Structure Of A Beta-Galactosidase From Bacteroides Thetaiotaomicron |
Metabolic Pathways | |||
---|---|---|---|
Pathway Name | Reaction | EC | Protein Name |
starch degradation I | RXN-2141 | EC-3.2.1.20 | α-glucosidase |