CAZyme Information: jhhlp_002636-t41_1-p1

Basic Information

• Species: Lomentospora prolificans
• Lineage: Ascomycota; Sordariomycetes; ; Microascaceae; Lomentospora; Lomentospora prolificans
• CAZyme ID: jhhlp_002636-t41_1-p1
• CAZy Family: AA9
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1524		169585.09	4.7462

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_LprolificansJHH5317	8768	N/A	208	8560

• Gene Location: location=NLAX01000008:3462566-3467293(+)

Full Sequence      

MKPRRLPASLGALLLTFASAPALAVPSISVSMRAAFPAGPYLLELIETAAAENSTSYFPL
LDRVAGGYFTDAASEKDLYDRFLALLLQDGHISDPDALSTFKLALSMRSAAPRIEAHYHY
YSTGVEPNFPSGSTPACDTWAFFDASRYCDYDSLSSLVVNGEPARLPDLPFDRVLGTGPS
VVLYTDMQLPSFASFHNSLVEMARRGDISYTVRYRRGERPEEDDSPLPVSGYGVELALKK
TDYIMIDDRDATTGRNGDSTVNRDSPDQIVLSEEEEVTDLKPLSKAEVSSLGVNAASLIM
KSESPFDTLVKFTEDFPKHSAWIASHNASDEFIKEQRENLGGIVPPGVNVLWMNGVQLIE
RQIEPFTLVDMLRRERKLIAEAKNIGLTGSQAIALLGHPNVTSAKVDGSSQRFDWRDERE
GGGVIMWLNDLESDTQYEEFPSVLTALLQRTYPGQVPRIRRNIFNAVIPIDVAKVDDLKV
ALQILAFVHRLLPVRFGLVPFSSNAGATDLMKVFYYLHDNYGLEGLFTYIELAAHGEQAA
ADDAMFEEAINAGSPPAGFKTQKLEEVLASTPLNERIRLTENWVGRLNVNSGTTPVLVNG
VIVPRIDNWLQGMGARINLDLQTLRQGLQLGEVNEGTSIQELFLQESVVSRNLRIYADDE
EGLNMIDLGKLYREHATLLRNVPVLDAYVDSTLENWATLSVVADLTSEDGLSLLQSALQF
KANNPGIRMDIIHNPIAETSMASEINAALVANSGKLLEAGSIQEIRSLLSSHAFAPDTSY
GTLLSSYLASTKLRPGSKGLILNGRVVGPLSDNEAFDEDGLQQLVEFERKNRILPVYSAV
TDLGLGKVIKDPLAAAKLTSLVALSTISDLPEGIFESAPTLRTSIFNTWRSRHTTIEVGD
PESASVHIVGLLNPASEQAQRWTPILKVLSQVDGVYVKLFLNPDERLEELPIKRFYRYVL
EAEPTFDEVGKVKPVGATFRGLPLDALLTVGMDVPPAWLVAAKSSVQDPDNIKLSLVKGD
VDAVYELRNILIEGHSRMVTQNTAPPSGAQLVLGTEKTPHSADTIIMANLGYFQFKANPG
FYNIQLQTGRSSEIFEIESVGALGYGVSPGDEGTSVALMDFKGTTLYPRLKRKPGMETAD
VLSDGANEAKPSSENLLSRGFKAAAEFLGGSDAKASGGDKGKPLKEHADINIFSVASGHL
YERMLNIMMLSVMKHTDHTVKFWFIEQFLSPSFKDSIPHLAREYGFQYEMVAYKWPHWLR
QQKEKQREIWGYKILFLDVLFPLSLDKVIFVDADQIVRADMMELVNYNLEGAPYGFTPMC
DSRTEMEGFRFWKQGYWANYLRGLPYHISALYVVDLRRFRELAAGDRLRQQYHTLSADPN
SLANLDQDLPNHMQFMIPIHSLPQEWLWCETWCSDESLRDAKTIDLCNNPMTKEPKLDRA
RRQVPEWTVYDEEIAAFERKRKGETTAEDRKEVPSVQEQEQLKEKEEAQSQAAEDDGENE
PAVERNTKSRKWEEEPSSRVKDEL

Enzyme Prediction     

EC	2.4.1.-:29

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT24	1190	1437	1.6e-134	0.9959677419354839

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
133054	GT8_HUGT1_C_like	0.0	1190	1437	1	248	The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family. C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
408203	Glyco_transf_24	0.0	1190	1457	1	268	Glucosyltransferase 24. This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
408201	Thioredoxin_14	5.85e-77	413	655	1	248	Thioredoxin-like domain. This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
408202	Thioredoxin_15	2.13e-64	667	863	1	204	Thioredoxin-like domain. This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
399437	UDP-g_GGTase	1.60e-60	1033	1143	1	109	UDP-glucose:Glycoprotein Glucosyltransferase. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
UQC87132.1|GT24	0.0	24	1524	83	1551
UPK89075.1|GT24	0.0	22	1463	20	1441
QKD49569.1|GT24	0.0	18	1463	14	1440
CCT67477.1|GT24	0.0	18	1462	5	1430
CEI40105.1|GT24	0.0	26	1463	22	1440

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5MU1_A	0.0	24	1460	7	1450	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5MZO_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TRF_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
5NV4_A	0.0	24	1460	7	1450	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
6TRT_A	0.0	24	1460	7	1450	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
6TS2_A	0.0	24	1460	7	1216	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_C Chain C, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_D Chain D, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
6TS8_A	0.0	26	1399	2	1382	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS8_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q09140|UGGG_SCHPO	2.85e-264	24	1456	18	1423	UDP-glucose:glycoprotein glucosyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gpt1 PE=1 SV=2
sp|Q09332|UGGG_DROME	1.14e-231	40	1454	42	1504	UDP-glucose:glycoprotein glucosyltransferase OS=Drosophila melanogaster OX=7227 GN=Uggt PE=1 SV=2
sp|Q6P5E4|UGGG1_MOUSE	1.58e-226	27	1454	46	1520	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Mus musculus OX=10090 GN=Uggt1 PE=1 SV=4
sp|Q9NYU2|UGGG1_HUMAN	9.35e-226	27	1454	46	1520	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3
sp|Q9JLA3|UGGG1_RAT	3.40e-224	27	1454	46	1520	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Uggt1 PE=1 SV=2

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000353	0.999620	CS pos: 24-25. Pr: 0.9740

TMHMM  Annotations     

Start	End
7	29