dbCAN-seq: a database of CAZyme sequence and annotation

Basic Information help

Species

Zymoseptoria tritici

Lineage

Ascomycota; Dothideomycetes; ; Mycosphaerellaceae; Zymoseptoria; Zymoseptoria tritici

CAZyme ID

ZTRI_1.141.mRNA-p1

CAZy Family

AA2

CAZyme Description

hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1035		110364.75	5.0536

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_ZtriticiIPO323	11839	336722	13	11826

Gene Location

Enzyme Prediction help

No EC number prediction in ZTRI_1.141.mRNA-p1.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
CE3	425	625	7.4e-48	0.9948453608247423

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
238871	XynB_like	1.35e-37	425	625	1	157	SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.
395036	Sugar_tr	4.51e-36	793	994	59	256	Sugar (and other) transporter.
340914	MFS_HXT	6.99e-28	793	930	58	195	Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins. The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
370992	GPI-anchored	3.46e-27	35	130	1	93	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family. Some members of this family appear to be serine- threonine-rich membrane-anchored proteins, anchored by glycosyl-phosphatidylinositol. In A. fumigatus these proteins play a role in fungal cell wall organisation. In Lentinula edodes this family is involved in fruiting body formation, and may have a more general role in signalling in other organisms as it interacts with MAPK. The family is also found in archaea and bacteria.
340918	MFS_HMIT_like	1.08e-24	794	928	49	180	H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start
0.0	333	1009	31	707
3.97e-235	333	692	31	390
1.81e-233	333	692	31	390
1.12e-229	333	692	31	382
6.43e-45	425	633	7	209

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
1.19e-15	793	974	67	266	Crystal structure of D-xylose-proton symporter [Escherichia coli K-12]
1.22e-15	793	974	68	267	Partially occluded inward open conformation of the xylose transporter XylE from E. coli [Escherichia coli K-12],4JA3_B Partially occluded inward open conformation of the xylose transporter XylE from E. coli [Escherichia coli K-12],4JA4_A Inward open conformation of the xylose transporter XylE from E. coli [Escherichia coli K-12],4JA4_B Inward open conformation of the xylose transporter XylE from E. coli [Escherichia coli K-12],4JA4_C Inward open conformation of the xylose transporter XylE from E. coli [Escherichia coli K-12]
1.26e-15	793	974	68	267	The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to D-xylose [Escherichia coli K-12],4GBZ_A The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to D-glucose [Escherichia coli K-12],4GC0_A The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to 6-bromo-6-deoxy-D-glucose [Escherichia coli K-12]
1.40e-15	793	974	95	294	Crystal structure of a double Trp XylE mutants (G58W/L315W) [Escherichia coli]
2.02e-10	775	976	54	255	Structure of the human glucose transporter GLUT3 / SLC2A3 [Homo sapiens],5C65_B Structure of the human glucose transporter GLUT3 / SLC2A3 [Homo sapiens]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
7.86e-33	793	980	76	261	MFS-type transporter oryC OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=oryC PE=3 SV=1
1.17e-30	793	994	80	283	Major facilitator superfamily transporter mfsA OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=mfsA PE=2 SV=1
1.99e-25	793	973	90	273	Sugar transporter STL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=STL1 PE=1 SV=2
2.48e-17	793	996	132	330	Galactose transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=GAL2 PE=1 SV=3
9.59e-17	795	958	156	319	Low glucose sensor SNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=SNF3 PE=1 SV=3

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000200	0.999756	CS pos: 20-21. Pr: 0.9667

TMHMM Annotations download full data without filtering help

Start	End
812	834
870	892
902	924

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