CAZyme Information: Z517_11949-t43_1-p1

Basic Information

• Species: Fonsecaea pedrosoi
• Lineage: Ascomycota; Eurotiomycetes; ; Herpotrichiellaceae; Fonsecaea; Fonsecaea pedrosoi
• CAZyme ID: Z517_11949-t43_1-p1
• CAZy Family: GT57
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1489		166941.96	4.8391

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_FpedrosoiCBS271-37	12573	1442368	46	12527

• Gene Location: location=KN846976:1759938-1764467(-)

Full Sequence      

MRTLHKRWTCSLLALLSWDSLITPTRATSSVNVALQTSFSAGPYLVELLETAALENSSSY
FPLLDRIADGTFTDLQTEQELYTKFLDVVQNDGHLSTPESVSSFKFALALHAAAPRVEAH
FQYYNTSVQPHLMAAQDAVCPVWVYLDGQQFCSPTLDRAQQMVSIPDTVNDLPFDRVLGA
SSDGPSSILYADITHPLFGQFHSVVSQTAREGKSTYRVRYRPSTMVSSRPIYVTGYGVEL
VLKRTDYIVIDDRDAQKTGDSTPEQLSLETKDDEIKDLKPLTTSEVAKLGINAASFILSS
SSPLDTLLQVTSDFPKYSSLLASVNASKEFVLEHRANRERFLPSGYNVLWINGVQIEPRQ
MNAYSLLDHLRRERRIIAELKSLGLASSEAISLLSSEIIAEAQANETPQRFDWRDDSEAG
GVLMWLNDLEQDKRYAGWSSSLRSLFQRTYPGQLPQVSRDIHNLIVPIDMGNMKDIELVT
TSLQSLVRRQVPIRIALIPTGEGETADTYSKVAYHISDTYGLTALMSFFSDIVAAKRIDT
SPEKSFKTAIRGRATREGKEPLAFHEVLNDESLGLRLQARDEYMKRLALARPNPPLLVNG
VVIPRTDNWFELLSARLYADLQLVQQAVFQEAILEESWVPEFFLFQAVKRRNEMVFPDNA
KDVEIVDVGQIATDFADSFARLPRLAGAEATLLSDRAHLLVVVDLESETGRILLSEALLF
HQRNPEIEMLIIHNPGPESQTSSFARGLYALLQENGRDLTVDSLEQLLKGDLSSSADNLT
DASTEFWSSHTDLLQTLSFSEGQNGLWLNGRLLGPLDQGFTSGDFEALLEFERRERIAPV
TTSITGLALEDRFTGALDLAKITSLVARSLKSDLPEGLRESAPLIRMERFKFWNSTHTSI
NISNSDDINIQIVASIDPASELVQQWVPILESLSQLNGVSVQIFLNPKDRLTELPVKRFF
RQVISAEPSFDSHGSLSIPNASFSGIPKDTLFNLGMVVPPSWLVAPKISIHDLDNIRLSN
LAEGENIDAVYELEHILIEGHARDVTSGPPPRGVQLLLGTEDEPHFTDTIVMANLGYFQF
KANPGYWQISLKPGRSSKIFNIDSVGPHGYSAQPGDETTSVALLSFQGLTLFPRLSRKPG
MEEEDVLESSALGGAMDYLNKGASFASSALSSLGFKKTSSNADINIFSVASGHLYERMLN
IMMVSVMKHTKHSVKFWFIEQFLSPSFKSTLPILAEHYGFDYEMVTYKWPHWLRGQKEKQ
REIWGYKILFLDVLFPLDLDKVIFVDADQIVRTDMMELNKVDLKGAPYGFTPMCDSRTEM
EGFRFWKQGYWETYLRGKPYHISALYVVDLKRFRQLAAGDRLRQQYQALSADPASLSNLD
QDLPNHMQHSLPIHSLSQEWLWCETWCDDASLAKAKTIDLCNNPLTKEPKLDRAKRQVPE
WTLYDEEIAGVIRAAKEQASTVTDSEGLEDAADGENLENVESERIRDEL

Enzyme Prediction     

EC	2.4.1.-:29

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT24	1184	1431	1.7e-134	0.9959677419354839

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
408203	Glyco_transf_24	0.0	1184	1451	1	268	Glucosyltransferase 24. This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
133054	GT8_HUGT1_C_like	0.0	1184	1431	1	248	The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family. C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
408201	Thioredoxin_14	2.72e-83	411	655	1	248	Thioredoxin-like domain. This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
399437	UDP-g_GGTase	9.87e-68	1039	1148	1	109	UDP-glucose:Glycoprotein Glucosyltransferase. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER.
408199	Thioredoxin_12	2.72e-58	43	224	3	180	Thioredoxin-like domain. This is one of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BCR94558.1|GT24	0.0	26	1451	27	1455
BCS07152.1|GT24	0.0	26	1451	27	1455
CAK39488.1|GT24	0.0	26	1489	27	1495
CAS97678.1|GT24	0.0	26	1489	27	1495
UDD64319.1|GT24	0.0	27	1470	27	1478

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5MU1_A	0.0	27	1458	7	1454	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5MZO_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TRF_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
5NV4_A	0.0	27	1458	7	1454	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
5Y7O_A	0.0	29	1149	4	1125	Crystal structure of folding sensor region of UGGT from Thermomyces dupontii [Thermomyces dupontii],5Y7O_B Crystal structure of folding sensor region of UGGT from Thermomyces dupontii [Thermomyces dupontii]
6TRT_A	0.0	27	1458	7	1454	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
6TS2_A	0.0	27	1458	7	1220	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_C Chain C, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_D Chain D, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q09140|UGGG_SCHPO	5.05e-278	20	1459	11	1432	UDP-glucose:glycoprotein glucosyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gpt1 PE=1 SV=2
sp|Q09332|UGGG_DROME	2.06e-240	20	1448	15	1504	UDP-glucose:glycoprotein glucosyltransferase OS=Drosophila melanogaster OX=7227 GN=Uggt PE=1 SV=2
sp|Q6P5E4|UGGG1_MOUSE	6.21e-234	7	1448	22	1520	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Mus musculus OX=10090 GN=Uggt1 PE=1 SV=4
sp|Q9JLA3|UGGG1_RAT	1.80e-232	30	1448	46	1520	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Uggt1 PE=1 SV=2
sp|Q9NYU2|UGGG1_HUMAN	1.67e-229	30	1458	46	1531	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000344	0.999636	CS pos: 27-28. Pr: 0.9654

TMHMM  Annotations     

There is no transmembrane helices in Z517_11949-t43_1-p1.