CAZyme Information: TSTA_079960-t26_1-p1

Basic Information

• Species: Talaromyces stipitatus
• Lineage: Ascomycota; Eurotiomycetes; ; Trichocomaceae; Talaromyces; Talaromyces stipitatus
• CAZyme ID: TSTA_079960-t26_1-p1
• CAZy Family: GH32|CBM38
• CAZyme Description: endoglucanase, putative

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
811		87299.79	4.6212

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_TstipitatusATCC10500	12629	441959	146	12483

• Gene Location: location=EQ962652:5570808-5573636(+)

Full Sequence      

MAHVVSIATLLAVGLLVDSASAAVSQAYTWKNVKTGGGGGFVPGIVFNPSAKGVVYARTD
IGGAYRLNKDDTWTPLLDSVNNSNWHDWGIDAIATDPIDTDRLYLAVGMYTNEWDPSPGS
IMQSKDMGKTWQETELPFKVGGNMPGRGVGERLAVDPNDNSIIYFGARSGHGLWKSTDYG
ATWSNVTSFIWTGTYFQNSSSSYTSDPVGISWVTFDSTSGTKGSPTPRIFVGVVDTGKSV
FKSEDGGATWAWVSGEPMYGFLPHKGILSPAEKTLYISYSNGAGPYDGTNGTVHKYNIST
GVWTDISPTPMASAYYGYGGLAVDLQVPGTIMVAALNCWWPDELIWRSLDSGATWSSIWA
WDGYPNIDYYYSYDISNAPWLQDNTSTAQFPVRIGWMVEALAIDPFDSNHWLYGTGATIY
GGHDLLKWDSIHNVTVKSLAVGVEEMAVLGLISPPGGPPLLSAVGDEGGFYHADLDTAPD
QYFHNPTYSSTNGIDYAGNNPSIIVRSGSSSTLPTVSISRDFGLTWSADYAASNNTVPGS
VALSADGDTVLLSPTTGSPLVSKYSSTFSAVSGLPAGAVIASDKSNNTVFYGGYSGSLYL
STNGGVSFNKTVTLGSSTAVNAIRAHPSIAGDVWISTDTGLWHSTSFGESSVHIDSGCTA
GWSFGLGKAATSASYSVIFGFFTVDGVTALFKTEDQGINWQMISDSTHGFGASSANIVNG
DMSNYGRVFVGTNGRGILYDIANQCRVVYNYAEINDYIYFQHIIHSINLSEIHCSHNDQF
GHRYNCIPIWPVWRFWVYGTNYLSQWVDMYV

Enzyme Prediction     

EC	3.2.1.151:27	3.2.1.150:4	3.2.1.151:5	3.2.1.151:27	3.2.1.150:4

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH74	78	187	2e-23	0.45493562231759654

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
406353	Sortilin-Vps10	3.38e-06	72	193	12	123	Sortilin, neurotensin receptor 3,. Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.
271234	Sialidase_non-viral	4.75e-05	102	250	157	293	Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.
214740	VPS10	9.51e-05	119	282	55	253	VPS10 domain.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QGA17431.1|CBM1|GH74	0.0	9	739	9	739
CAK43558.1|CBM1|GH74	0.0	11	739	8	735
AAK77227.1|CBM1|GH74|3.2.1.151	0.0	11	739	8	735
EAA60055.1|CBM1|GH74	0.0	15	743	15	744
BAA29031.1|CBM1|GH74	0.0	10	738	8	736

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
6MGL_A	1.38e-232	24	739	2	743	Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, D60A mutant in complex with XXLG and XGXXLG xyloglucan [Paenibacillus odorifer]
6MGJ_A	1.31e-227	25	739	3	743	Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, apoenzyme [Paenibacillus odorifer],6MGJ_B Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, apoenzyme [Paenibacillus odorifer],6MGJ_C Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, apoenzyme [Paenibacillus odorifer],6MGJ_D Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, apoenzyme [Paenibacillus odorifer],6MGJ_E Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, apoenzyme [Paenibacillus odorifer],6MGJ_F Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, apoenzyme [Paenibacillus odorifer],6MGJ_G Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, apoenzyme [Paenibacillus odorifer],6MGJ_H Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, apoenzyme [Paenibacillus odorifer],6MGK_A Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, in complex with XLX xyloglucan [Paenibacillus odorifer],6MGK_B Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, in complex with XLX xyloglucan [Paenibacillus odorifer],6MGK_C Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, in complex with XLX xyloglucan [Paenibacillus odorifer],6MGK_D Crystal structure of the catalytic domain from GH74 enzyme PoGH74 from Paenibacillus odorifer, in complex with XLX xyloglucan [Paenibacillus odorifer]
4LGN_A	1.02e-224	23	742	2	736	The structure of Acidothermus cellulolyticus family 74 glycoside hydrolase [Acidothermus cellulolyticus 11B]
6P2N_A	1.12e-223	23	739	1	744	Crystal structure of Paenibacillus graminis GH74 (PgGH74) [Paenibacillus graminis]
6P2O_A	2.86e-210	26	738	1	722	Crystal structure of Streptomyces rapamycinicus GH74 in complex with xyloglucan fragments XLLG and XXXG [Streptomyces rapamycinicus NRRL 5491],6P2O_B Crystal structure of Streptomyces rapamycinicus GH74 in complex with xyloglucan fragments XLLG and XXXG [Streptomyces rapamycinicus NRRL 5491]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q7Z9M8|XG74_HYPJQ	5.79e-257	16	739	9	742	Xyloglucanase OS=Hypocrea jecorina (strain QM6a) OX=431241 GN=cel74a PE=1 SV=1
sp|Q3MUH7|XG74_PAESP	3.20e-244	6	739	13	763	Xyloglucanase OS=Paenibacillus sp. OX=58172 GN=xeg74 PE=1 SV=1
sp|A3DFA0|XG74_ACET2	2.65e-209	19	739	29	755	Xyloglucanase Xgh74A OS=Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) OX=203119 GN=xghA PE=3 SV=1
sp|Q70DK5|XG74_ACETH	1.06e-208	19	739	29	755	Xyloglucanase Xgh74A OS=Acetivibrio thermocellus OX=1515 GN=xghA PE=1 SV=1
sp|Q8J0D2|CBHRE_GEOS1	3.81e-91	22	744	21	788	Oligoxyloglucan reducing end-specific cellobiohydrolase OS=Geotrichum sp. (strain M128) OX=203496 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000234	0.999731	CS pos: 22-23. Pr: 0.9779

TMHMM  Annotations     

There is no transmembrane helices in TSTA_079960-t26_1-p1.