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CAZyme Information: TPX38637.1
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Synchytrium endobioticum | |||||||||||
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| Lineage | Chytridiomycota; Chytridiomycetes; ; Synchytriaceae; Synchytrium; Synchytrium endobioticum | |||||||||||
| CAZyme ID | TPX38637.1 | |||||||||||
| CAZy Family | CE4 | |||||||||||
| CAZyme Description | argininosuccinate lyase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | ||||||||||||
Enzyme Prediction help
| EC | 2.4.1.257:6 | 2.4.1.132:6 |
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CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| 176463 | Argininosuccinate_lyase | 0.0 | 22 | 454 | 1 | 434 | Argininosuccinate lyase (argininosuccinase, ASAL). This group contains ASAL and related proteins. It is a member of the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. ASAL is a cytosolic enzyme which catalyzes the reversible breakdown of argininosuccinate to arginine and fumarate during arginine biosynthesis. In ureotelic species ASAL also catalyzes a reaction involved in the production of urea. Included in this group are the major soluble avian eye lens proteins from duck, delta 1 and delta 2 crystallin. Of these two isoforms only delta 2 has retained ASAL activity. These crystallins may have evolved by, gene recruitment of ASAL followed by gene duplication. In humans, mutations in ASAL result in the autosomal recessive disorder argininosuccinic aciduria. |
| 223243 | ArgH | 0.0 | 1 | 453 | 3 | 455 | Argininosuccinate lyase [Amino acid transport and metabolism]. |
| 340834 | GT4_ALG2-like | 0.0 | 476 | 879 | 2 | 388 | alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans. |
| 215348 | PLN02646 | 0.0 | 3 | 459 | 18 | 474 | argininosuccinate lyase |
| 179143 | PRK00855 | 0.0 | 1 | 454 | 4 | 457 | argininosuccinate lyase; Provisional |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| 7.00e-118 | 476 | 879 | 7 | 412 | |
| 7.00e-118 | 476 | 879 | 7 | 412 | |
| 4.53e-113 | 477 | 879 | 8 | 409 | |
| 1.10e-109 | 472 | 875 | 4 | 414 | |
| 1.10e-109 | 472 | 878 | 4 | 417 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 3.28e-180 | 3 | 452 | 8 | 456 | Chain A, Argininosuccinate Lyase [Homo sapiens],1K62_B Chain B, Argininosuccinate Lyase [Homo sapiens] |
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| 3.28e-180 | 3 | 452 | 8 | 456 | Human Argininosuccinate Lyase [Homo sapiens],1AOS_B Human Argininosuccinate Lyase [Homo sapiens] |
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| 2.69e-177 | 3 | 453 | 10 | 459 | Chain A, delta 2 crystallin [Anas platyrhynchos],1K7W_B Chain B, delta 2 crystallin [Anas platyrhynchos],1K7W_C Chain C, delta 2 crystallin [Anas platyrhynchos],1K7W_D Chain D, delta 2 crystallin [Anas platyrhynchos] |
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| 7.60e-177 | 3 | 453 | 10 | 459 | Crystal Structure Of Wild Type Duck Delta 2 Crystallin (Eye Lens Protein) [Anas platyrhynchos],1HY1_B Crystal Structure Of Wild Type Duck Delta 2 Crystallin (Eye Lens Protein) [Anas platyrhynchos],1HY1_C Crystal Structure Of Wild Type Duck Delta 2 Crystallin (Eye Lens Protein) [Anas platyrhynchos],1HY1_D Crystal Structure Of Wild Type Duck Delta 2 Crystallin (Eye Lens Protein) [Anas platyrhynchos] |
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| 3.73e-176 | 3 | 453 | 10 | 459 | Chain A, Delta crystallin II [Anas platyrhynchos],1TJU_B Chain B, Delta crystallin II [Anas platyrhynchos],1TJU_C Chain C, Delta crystallin II [Anas platyrhynchos],1TJU_D Chain D, Delta crystallin II [Anas platyrhynchos] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 1.00e-210 | 3 | 453 | 7 | 457 | Probable argininosuccinate lyase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=argx PE=3 SV=1 |
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| 8.68e-198 | 3 | 452 | 14 | 464 | Argininosuccinate lyase OS=Candida albicans OX=5476 GN=ARG4 PE=3 SV=1 |
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| 2.39e-193 | 3 | 456 | 8 | 463 | Argininosuccinate lyase OS=Saccharomyces paradoxus OX=27291 GN=ARG4 PE=3 SV=1 |
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| 3.15e-193 | 3 | 452 | 9 | 457 | Argininosuccinate lyase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=arg7 PE=1 SV=2 |
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| 1.53e-191 | 3 | 456 | 8 | 463 | Argininosuccinate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ARG4 PE=1 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | CS Position |
|---|---|---|
| 1.000067 | 0.000000 |