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CAZyme Information: TPX35203.1
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Synchytrium endobioticum | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Chytridiomycota; Chytridiomycetes; ; Synchytriaceae; Synchytrium; Synchytrium endobioticum | |||||||||||
| CAZyme ID | TPX35203.1 | |||||||||||
| CAZy Family | AA3 | |||||||||||
| CAZyme Description | dolichyl-phosphate-mannose---protein mannosyltransferase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | ||||||||||||
Enzyme Prediction help
| EC | 2.4.1.109:12 |
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CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GT39 | 905 | 1143 | 8.5e-69 | 0.9865470852017937 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| 224839 | PMT1 | 0.0 | 902 | 1583 | 28 | 697 | Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]. |
| 293851 | CPSF2-like_MBL-fold | 8.22e-99 | 7 | 209 | 1 | 199 | cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; MBL-fold metallo-hydrolase domain. CPSF2, also known as cleavage and polyadenylation specificity factor 100 kDa subunit (CPSF-100), is a component of the CPSF complex, which plays a role in 3' end processing of pre-mRNAs during cleavage/polyadenylation, and during processing of metazoan histone pre-mRNAs. This subgroup includes Ydh1p, the yeast homolog of CPSF2. In addition to this MBL-fold metallo-hydrolase domain, members of this subgroup contain a beta-CASP (named for metallo-beta-lactamase, CPSF, Artemis, Snm1, Pso2) domain. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. |
| 396786 | PMT | 7.85e-77 | 904 | 1146 | 3 | 244 | Dolichyl-phosphate-mannose-protein mannosyltransferase. This is a family of Dolichyl-phosphate-mannose-protein mannosyltransferase proteins EC:2.4.1.109. These proteins are responsible for O-linked glycosylation of proteins, they catalyze the reaction:- Dolichyl phosphate D-mannose + protein <=> dolichyl phosphate + O-D-mannosyl-protein. Also in this family is Drosophila rotated abdomen protein which is a putative mannosyltransferase. This family appears to be distantly related to pfam02516 (A Bateman pers. obs.). This family also contains sequences from ArnTs (4-amino-4-deoxy-L-arabinose lipid A transferase). They catalyze the addition of 4-amino-4-deoxy-l-arabinose (l-Ara4N) to the lipid A moiety of the lipopolysaccharide. This is a critical modification enabling bacteria (e.g. Escherichia coli and Salmonella typhimurium) to resist killing by antimicrobial peptides such as polymyxins. Members such as undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase are predicted to have 12 trans-membrane regions. The N-terminal portion of these proteins is hypothesized to have a conserved glycosylation activity which is shared between distantly related oligosaccharyltransferases ArnT and PglB families. |
| 406576 | PMT_4TMC | 1.24e-67 | 1385 | 1571 | 1 | 195 | C-terminal four TMM region of protein-O-mannosyltransferase. PMT_4TMC is the C-terminal four membrane-pass region of protein-O-mannosyltransferases and similar enzymes. |
| 406948 | Lactamase_B_6 | 1.20e-63 | 22 | 204 | 1 | 192 | Metallo-beta-lactamase superfamily domain. This family is part of the metallo-beta-lactamase superfamily. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| 8.67e-227 | 897 | 1585 | 110 | 790 | |
| 2.08e-210 | 904 | 1583 | 55 | 753 | |
| 2.08e-210 | 904 | 1583 | 55 | 753 | |
| 5.50e-210 | 889 | 1583 | 49 | 760 | |
| 6.65e-210 | 888 | 1583 | 57 | 766 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2.64e-158 | 904 | 1603 | 56 | 760 | Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor and a peptide acceptor [Saccharomyces cerevisiae W303],6P2R_A Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor [Saccharomyces cerevisiae W303] |
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| 1.34e-155 | 1 | 815 | 1 | 772 | Cryo-EM structure of human CPSF160-WDR33-CPSF30-CPSF100 PIM complex [Homo sapiens],6V4X_I Chain I, Cleavage and polyadenylation specificity factor subunit 2 [Homo sapiens] |
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| 7.26e-113 | 856 | 1533 | 24 | 703 | Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor and a peptide acceptor [Saccharomyces cerevisiae W303],6P2R_B Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor [Saccharomyces cerevisiae W303] |
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| 7.55e-37 | 5 | 358 | 4 | 350 | Chain k, Integrator complex subunit 11 [Homo sapiens] |
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| 7.55e-37 | 5 | 358 | 4 | 350 | The structure of human Integrator-PP2A complex [Homo sapiens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6.03e-172 | 838 | 1583 | 5 | 749 | Dolichyl-phosphate-mannose--protein mannosyltransferase 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=PMT1 PE=2 SV=1 |
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| 1.36e-157 | 904 | 1603 | 56 | 760 | Dolichyl-phosphate-mannose--protein mannosyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PMT1 PE=1 SV=1 |
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| 6.85e-156 | 1 | 815 | 1 | 772 | Cleavage and polyadenylation specificity factor subunit 2 OS=Mus musculus OX=10090 GN=Cpsf2 PE=1 SV=1 |
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| 1.84e-155 | 1 | 815 | 1 | 772 | Cleavage and polyadenylation specificity factor subunit 2 OS=Bos taurus OX=9913 GN=CPSF2 PE=1 SV=1 |
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| 6.90e-155 | 1 | 815 | 1 | 772 | Cleavage and polyadenylation specificity factor subunit 2 OS=Homo sapiens OX=9606 GN=CPSF2 PE=1 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | CS Position |
|---|---|---|
| 1.000049 | 0.000001 |
TMHMM Annotations download full data without filtering help
| Start | End |
|---|---|
| 983 | 1002 |
| 1009 | 1031 |
| 1035 | 1057 |
| 1064 | 1081 |
| 1085 | 1103 |
| 1124 | 1146 |
| 1441 | 1463 |
| 1476 | 1498 |
| 1508 | 1527 |
| 1534 | 1556 |