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CAZyme Information: TPX26509.1
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Coccidioides immitis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Ascomycota; Eurotiomycetes; ; Onygenaceae; Coccidioides; Coccidioides immitis | |||||||||||
| CAZyme ID | TPX26509.1 | |||||||||||
| CAZy Family | GT8 | |||||||||||
| CAZyme Description | N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit alg13 | |||||||||||
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| Genome Property |
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CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| 397977 | Glyco_tran_28_C | 2.37e-16 | 31 | 173 | 1 | 121 | Glycosyltransferase family 28 C-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site. |
| 227350 | COG5017 | 6.60e-16 | 33 | 198 | 3 | 144 | UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism]. |
| 340818 | GT28_MurG | 9.48e-07 | 37 | 171 | 192 | 300 | undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. |
| 340817 | GT1_Gtf-like | 9.20e-06 | 125 | 150 | 309 | 334 | UDP-glycosyltransferases and similar proteins. This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics. |
| 223779 | MurG | 1.16e-05 | 46 | 194 | 163 | 328 | UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis]. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| 2.72e-158 | 1 | 223 | 1 | 223 | |
| 3.72e-79 | 29 | 223 | 7 | 200 | |
| 5.28e-79 | 29 | 223 | 7 | 200 | |
| 9.83e-70 | 29 | 214 | 7 | 190 | |
| 6.37e-63 | 27 | 223 | 4 | 200 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 1.38e-14 | 30 | 172 | 6 | 158 | NMR solution structure of ALG13 --- obtained with iterative CS-Rosetta from backbone NMR data. [Saccharomyces cerevisiae] |
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| 2.00e-14 | 30 | 172 | 29 | 181 | NMR solution structure of ALG13: The sugar donor subunit of a yeast N-acetylglucosamine transferase. Northeast Structural Genomics Consortium target YG1 [Saccharomyces cerevisiae] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 9.58e-49 | 30 | 223 | 5 | 197 | UDP-N-acetylglucosamine transferase subunit alg13 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=alg13 PE=3 SV=2 |
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| 9.86e-20 | 33 | 186 | 4 | 136 | UDP-N-acetylglucosamine transferase subunit alg13 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=alg13 PE=3 SV=1 |
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| 7.89e-17 | 29 | 189 | 74 | 252 | UDP-N-acetylglucosamine transferase subunit ALG13 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=ALG13 PE=3 SV=2 |
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| 1.73e-16 | 29 | 199 | 1 | 147 | UDP-N-acetylglucosamine transferase subunit ALG13 homolog OS=Rattus norvegicus OX=10116 GN=Alg13 PE=1 SV=1 |
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| 2.56e-15 | 29 | 174 | 1 | 124 | Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 OS=Mus musculus OX=10090 GN=Alg13 PE=1 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | CS Position |
|---|---|---|
| 1.000056 | 0.000000 |