logo
sublogo
You are browsing environment: FUNGIDB
help

CAZyme Information: RQM11764.1

You are here: Home > Sequence: RQM11764.1

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Peronospora effusa
Lineage Oomycota; NA; ; Peronosporaceae; Peronospora; Peronospora effusa
CAZyme ID RQM11764.1
CAZy Family GH16|GT48
CAZyme Description unspecified product
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
1886 210719.58 7.2966
Genome Property
Genome Version/Assembly ID Genes Strain NCBI Taxon ID Non Protein Coding Genes Protein Coding Genes
FungiDB-61_PeffusaR13 8603 N/A 0 8603
Gene Location

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in RQM11764.1.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH72 2 199 1.1e-38 0.5673076923076923

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
380950 SET_NSD 6.89e-55 475 615 1 142
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins. The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.
380949 SET_SETD2 5.03e-52 475 615 1 142
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins. SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.
380929 SET_SETD2-like 1.12e-51 477 611 1 136
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins. This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.
380951 SET_ASH1L 2.01e-50 478 616 2 141
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins. ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).
380952 SET_ASHR3-like 7.49e-44 477 615 1 139
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins. This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
0.0 1 1886 631 2516
5.67e-112 87 322 1 237
1.81e-111 3 301 138 440
7.02e-105 3 303 154 458
3.62e-96 3 320 2299 2612

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
8.33e-45 422 620 48 244
Chain L, Histone-lysine N-methyltransferase SETD2 [Homo sapiens]
1.18e-44 422 620 53 249
crystal structure of SESTD2 in complex with H3.3S31phK36M peptide [Homo sapiens]
2.16e-44 422 620 66 262
Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF [Homo sapiens],4H12_A The crystal structure of methyltransferase domain of human SET domain-containing protein 2 in complex with S-adenosyl-L-homocysteine [Homo sapiens],7LZB_A Chain A, Histone-lysine N-methyltransferase SETD2 [Homo sapiens],7LZD_A Chain A, Histone-lysine N-methyltransferase SETD2 [Homo sapiens],7LZF_A Chain A, Histone-lysine N-methyltransferase SETD2 [Homo sapiens]
2.22e-44 422 620 67 263
Crystal structure of SETD2 bound to histone H3.3 K36M peptide [Homo sapiens],5JLB_A Crystal structure of SETD2 bound to histone H3.3 K36I peptide [Homo sapiens],5JLE_A Crystal structure of SETD2 bound to SAH [Homo sapiens]
3.47e-44 422 620 83 279
Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives [Homo sapiens],5LSX_A Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives [Homo sapiens],5LSY_A Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives [Homo sapiens],5LSZ_A Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives [Homo sapiens],5LT6_A Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives [Homo sapiens],5LT6_B Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives [Homo sapiens],5LT7_A Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives [Homo sapiens],5LT8_A Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives [Homo sapiens],6VDB_A SETD2 in complex with a H3-variant peptide [Homo sapiens]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
3.85e-39 422 620 1473 1669
Histone-lysine N-methyltransferase SETD2 OS=Mus musculus OX=10090 GN=Setd2 PE=1 SV=1
5.07e-39 422 620 1499 1695
Histone-lysine N-methyltransferase SETD2 OS=Homo sapiens OX=9606 GN=SETD2 PE=1 SV=3
5.85e-38 442 624 1908 2091
Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1
6.53e-37 442 634 1806 2001
Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Mus musculus OX=10090 GN=Nsd1 PE=1 SV=1
2.14e-36 441 650 191 405
Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=set2 PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI CS Position
1.000064 0.000001

TMHMM  Annotations      help

There is no transmembrane helices in RQM11764.1.