CAZyme Information: QYA_189922T0-p1

Basic Information

• Species: Mucor lusitanicus
• Lineage: Mucoromycota; Mucoromycetes; ; Mucoraceae; Mucor; Mucor lusitanicus
• CAZyme ID: QYA_189922T0-p1
• CAZy Family: GT31
• CAZyme Description: Glycosyltransferase family 24 protein [Source:UniProtKB/TrEMBL;Acc:A0A162QGF2]

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1563	McirCBS277-49_SC05|CGC8	175520.23	5.1526

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_MlusitanicusCBS277-49	11852	747725	0	11852

• Gene Location: location=McirCBS277-49_SC05:558225-563220(+)

Full Sequence      

MTAPPRILKAILGLVTVGLCNLKHVSASAGTDASPTIDLTMIAPWSAPNLIVEVAETIAT
YNKSAYLHLIHDFVALEQHSASWTPHQTYKEAVKVISALGVDETNFFKLSLAIHEAAPRI
EAYNQFYRESIVPGVSAYNDNCDVWAHIEDQQYCELTQFIDALTSQSATSTKPIELLPFD
HVVSKSQADPTVALYTDRFSAKFAEFHNALNQHAISHVIRYRPDTANVPVPLYLSGYGVE
MALKKTDYLVIDDRSSQKATNIKDKIANMGKKLGQSLFQATQKETIEPVTPGEIHRLGFK
AAQYISKSSNPLATLNQLVQDFPKYAKSVSELDVDIELEEEILDNQLNFLHSGMSAVWLN
GKGLEFSQMDPFFLIRALRKERQLIASFEQLGFKPKDAIQVISNPAFTAASQASSSANAE
IFDMRDSPEEPSVIWWNDLEKDKRYDDWTSSMEDYVQPQYPGQLLPVKKNIFNLIMVEDL
GQQGSIARVVNELHMMIKRLVPVRFGVISIIKEKDSVSTQMAQSLSYLIEEHGKGAGMNF
LSTVLETLRAEGKSAPTPQMINDAFAKTASSSGKPKSGKKVTFEEALETQASYTQASSQF
LQRMGITELGAQDGIMFINGKLLEFNEERPWIQVLMPALHEITRNLQKMVYMGDFLDEKF
DYYQHVMTQPHVATHRNSFIVPSNAHPLVIQEFPTVRKSSQLKYLQAGEQDASINMWVSA
DLNTAHGLRLVSEALLYAESNPKVRVALIHNPAASISTDDVPEISVPIVDEQHHKPTFSD
LLGSIIFTNEDTHLEQVTTLVRNAIEQFGSESFEGNVVPEAIIPGSPIIEMEAKAQSIHW
RYLVDALEKDGLAASFQGIVVNSRVVGPLPPSAVFSKENFAALVDLEYSKRIAPIEQAIA
QVKYTMPANEAVADVLTQISVLIESDKAVTSKSLVEENEPVYRHRVYENIPKTKHTRLVI
GDSDSAFLQIGFIIDPLSETAQKWVPLINTLASVDGVSVTMYLNPVNGLQELPLKRFYRY
VFDKEPHFDPATGVQEIPTAYFDDLPTDPLYTLGVETTNAWHVTVREANMDLDNIVLKSL
SKEESGVSAVYELENILLEGHCLDSNSKSPPRGLEFEIATPSNHSHRDTLVMANLGYFQL
KALPGVWNLGLREGRSSAIYSIEDIGTQGKWNWDVSRQHNKAEQGSGLLALTSFEGITVM
PLVHKNPGMESEDVLESADDRKQHSDGSGLWSSFSSKLFGGGSGAKKDQDVITTTKPKQA
EINIFSVASGKLYERFLSIMIASVMEHTQSTVKFWFIENFLSPEFKDFVPHMAKAYSFDY
EMVTYKWPAWLRAQREKQRTIWGYKILFLDVLFPLDLDKVIFVDADQIVRTDLKELVDMD
LQGAPYGYTPFCSDRTEMDGFRFWSEGYWKTHLRGKPYHISALYVVDLVRFRQLAAGDRL
RAQYQQLSADPNSLANLDQDLPNNMQHIVPIFSLPQEWLWCETWCSDESLKTAKTIDLCN
NPLTKEPKLDRARRQIPEWENYDNEIDQLRKRVSLEHPPAVVADAHGEQIVISGKKEHLK
DEL

Enzyme Prediction     

EC	2.4.1.-:29

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT24	1262	1509	2e-135	0.9959677419354839

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
133054	GT8_HUGT1_C_like	0.0	1262	1509	1	248	The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family. C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
408203	Glyco_transf_24	0.0	1262	1529	1	268	Glucosyltransferase 24. This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
408201	Thioredoxin_14	3.62e-70	422	680	1	248	Thioredoxin-like domain. This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
132996	Glyco_transf_8	1.88e-61	1262	1509	1	246	Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.
399437	UDP-g_GGTase	5.67e-50	1099	1216	1	109	UDP-glucose:Glycoprotein Glucosyltransferase. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
CDS05797.1|GT24	0.0	17	1558	4	1463
QIW98903.1|GT24	0.0	32	1563	21	1512
AQQ13387.1|GT24	0.0	31	1550	22	1496
AOZ60530.1|GT24	0.0	31	1550	22	1496
QGA15584.1|GT24	0.0	10	1534	5	1460

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5MU1_A	8.56e-304	33	1538	7	1456	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5MZO_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TRF_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
5NV4_A	1.70e-303	33	1538	7	1456	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
6TRT_A	4.74e-303	33	1538	7	1456	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
6TS8_A	1.34e-260	34	1471	1	1382	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS8_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
6TS2_A	7.86e-249	33	1538	7	1222	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_C Chain C, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_D Chain D, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q09140|UGGG_SCHPO	2.15e-250	33	1536	18	1431	UDP-glucose:glycoprotein glucosyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gpt1 PE=1 SV=2
sp|Q9NYU2|UGGG1_HUMAN	1.53e-235	34	1536	44	1530	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3
sp|Q6P5E4|UGGG1_MOUSE	2.27e-232	34	1530	44	1524	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Mus musculus OX=10090 GN=Uggt1 PE=1 SV=4
sp|Q09332|UGGG_DROME	1.66e-230	8	1533	2	1511	UDP-glucose:glycoprotein glucosyltransferase OS=Drosophila melanogaster OX=7227 GN=Uggt PE=1 SV=2
sp|Q9JLA3|UGGG1_RAT	3.50e-230	10	1530	32	1524	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Uggt1 PE=1 SV=2

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000371	0.999593	CS pos: 27-28. Pr: 0.9724

TMHMM  Annotations     

There is no transmembrane helices in QYA_189922T0-p1.