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CAZyme Information: QSL66238.1

You are here: Home > Sequence: QSL66238.1

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Pneumocystis wakefieldiae
Lineage Ascomycota; Pneumocystidomycetes; ; Pneumocystidaceae; Pneumocystis; Pneumocystis wakefieldiae
CAZyme ID QSL66238.1
CAZy Family GT39
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
968 CP054541|CGC1 111942.20 6.7415
Genome Property
Genome Version/Assembly ID Genes Strain NCBI Taxon ID Non Protein Coding Genes Protein Coding Genes
FungiDB-61_Pwakefieldiae2A 3223 N/A 41 3182
Gene Location Start: 371059; End:374986  Strand: -

Full Sequence      Download help

MDLNIKAERM  LDLIKIFELK  DSFTGIMDMN  GGIHMKNREQ  NGYCIQQAPS  FRQNLVHNHQ60
YCSYSKENSI  ISIDELAELN  LNSSVNAVAH  DIGIASDSPF  PVCRNVNLSY  TDDFYSIDVT120
PIAIENSRVI  QSMSMPIRMD  DYNSSQIYSK  DSFKSFFDSN  SENMIYKKIK  NESSVFIEEP180
FMSFNVFDDK  KLLEKYRKRR  ESHNAVERRR  RDNINEKIQE  LAALVLRNPF  KDKIKLNMDS240
RDKGYCDFKL  NKGEILQQSV  NYIQCLQNYV  NELNSRSKLL  EDEVIKLGGD  INFTNEIKPV300
SYIPLNIENM  DSNGCDDNSF  NKKLRIYLEV  CNRVGGIYSV  LKSKAPVTSL  EYPYDRYIAI360
GKFTQSAINF  EVEQLSTEDQ  PTLHKTLQYM  KNRGISYTYG  RWLIDGAPRV  LLFDIGNAFH420
WLNEWKGDLW  NTTGIPSPPD  DSETNDAIAF  GYIVAWFLGE  FISHEYERAV  VVHFHEWLAG480
VALPLCRKRR  LDLTTIFTTH  ATILGRYLCA  DNADFYNNLQ  YFDVDYEAGK  RGIYHRYCIE540
RAAAHSADVF  TTVSHITAYE  SEHLLKRKPD  GVLPNGLNVV  KFAAVHEFQN  LHATFKQKIN600
EFVRGHFYGH  NDFDLDNTLY  FFISGRYEYR  NKGVDLYIES  LARLNQRMKA  SDSKMTVIAF660
IIMPAVTHSY  TVEALKGQAV  MKSLQNTIEH  IQKGIGQRIY  EKCCRHSKDF  DEKFIDTSSL720
LTDQDKILLK  RRVFALKRSI  LPPIVTHNMA  DNNDPILTHI  RRVQLFNSDE  DRVKIIFHPE780
FLNSNNPILP  LDYDDFVRGC  HLGVFPSYYE  PWGYTSAEAV  VMGVPSITTN  ISGFGCYMEN840
IIDNPSDYGV  YIVDRRMKSV  DESINQLTDI  MYDFTTKTRR  QRINQRNRCE  RLSDFLDWKI900
MGLEYIKARL  LALRRAYPNS  FDTDLIDKNI  DLALGTLIKV  PHPLSTPTSP  KYRNGLLSIH960
DLDDIQNI968

Enzyme Prediction      help

EC 2.4.1.11:48

CAZyme Signature Domains help

Created with Snap48961451932422903383874354845325806296777267748228719194635GT3
Family Start End Evalue family coverage
GT3 328 965 1.5e-281 0.9905808477237049

CDD Domains      download full data without filtering help

Created with Snap4896145193242290338387435484532580629677726774822871919329915GT3_GSY2-like329964Glycogen_syn202272bHLHzip_USF_MITF194281bHLHzip_scCBP1195273bHLHzip_MITF_like
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
340824 GT3_GSY2-like 0.0 329 915 10 590
glycogen synthase GSY2 and similar proteins. Glycogen synthase, which is most closely related to the GT3 family of glycosyltransferases, catalyzes the transfer of a glucose molecule from UDP-glucose to a terminal branch of a glycogen molecule, a rate-limit step of glycogen biosynthesis. GSY2, the member of this family in S. cerevisiae, has been shown to possess glycogen synthase activity.
399009 Glycogen_syn 0.0 329 964 5 635
Glycogen synthase. This family consists of the eukaryotic glycogen synthase proteins GYS1, GYS2 and GYS3. Glycogen synthase (GS) is the enzyme responsible for the synthesis of -1,4-linked glucose chains in glycogen. It is the rate limiting enzyme in the synthesis of the polysaccharide, and its activity is highly regulated through phosphorylation at multiple sites and also by allosteric effectors, mainly glucose 6-phosphate (G6P).
381393 bHLHzip_USF_MITF 2.73e-20 202 272 1 58
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family. The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.
381404 bHLHzip_scCBP1 1.13e-15 194 281 2 71
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae centromere-binding protein 1 (CBP-1) and similar proteins. CBP-1, also termed centromere promoter factor 1 (CPF1), or centromere-binding factor 1 (CBF1), is a bHLHzip protein that is required for chromosome stability and methionine prototrophy. It binds as a homodimer to the centromere DNA elements I (CDEI, GTCACATG) region of the centromere that is required for optimal centromere function.
381403 bHLHzip_MITF_like 1.01e-13 195 273 1 64
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated transcription factor family (MITF) family. The MITF (also known as microphthalmia-TFE, or MiT) family is a small family that contain a basic helix loop helix domain associated with a leucine zipper (bHLHZip). The MITF family comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF family can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.

CAZyme Hits      help

Created with Snap48961451932422903383874354845325806296777267748228719191968QSL66238.1|GT3326968BCS25120.1|GT3326968EAA58813.1|GT3329968CAK44379.1|GT3329968BCR93830.1|GT3
Hit ID E-Value Query Start Query End Hit Start Hit End
QSL66238.1|GT3 0.0 1 968 1 968
BCS25120.1|GT3 0.0 326 968 23 660
EAA58813.1|GT3 0.0 326 968 20 657
CAK44379.1|GT3 0.0 329 968 26 660
BCR93830.1|GT3 0.0 329 968 26 660

PDB Hits      download full data without filtering help

Created with Snap48961451932422903383874354845325806296777267748228719193299516U77_A3299515UX7_A3299515SUK_A3299515UW0_A3299514KQM_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
6U77_A 5.36e-288 329 951 16 657
yGsy2p in complex with small molecule [Saccharomyces cerevisiae S288C],6U77_B yGsy2p in complex with small molecule [Saccharomyces cerevisiae S288C],6U77_C yGsy2p in complex with small molecule [Saccharomyces cerevisiae S288C],6U77_D yGsy2p in complex with small molecule [Saccharomyces cerevisiae S288C]
5UX7_A 9.14e-288 329 951 36 677
Activated state yeast Glycogen Synthase in complex with UDP-xylose [Saccharomyces cerevisiae S288C],5UX7_B Activated state yeast Glycogen Synthase in complex with UDP-xylose [Saccharomyces cerevisiae S288C],5UX7_C Activated state yeast Glycogen Synthase in complex with UDP-xylose [Saccharomyces cerevisiae S288C],5UX7_D Activated state yeast Glycogen Synthase in complex with UDP-xylose [Saccharomyces cerevisiae S288C]
5SUK_A 1.09e-287 329 951 36 677
G6P bound activated state of yeast glycogen synthase 2 [Saccharomyces cerevisiae S288C],5SUK_B G6P bound activated state of yeast glycogen synthase 2 [Saccharomyces cerevisiae S288C],5SUK_C G6P bound activated state of yeast glycogen synthase 2 [Saccharomyces cerevisiae S288C],5SUK_D G6P bound activated state of yeast glycogen synthase 2 [Saccharomyces cerevisiae S288C]
5UW0_A 2.60e-287 329 951 36 677
Chain A, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW0_B Chain B, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW0_C Chain C, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW0_D Chain D, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW1_A Activated state yGsy2p in complex with UDP-galactose [Saccharomyces cerevisiae S288C],5UW1_B Activated state yGsy2p in complex with UDP-galactose [Saccharomyces cerevisiae S288C],5UW1_C Activated state yGsy2p in complex with UDP-galactose [Saccharomyces cerevisiae S288C],5UW1_D Activated state yGsy2p in complex with UDP-galactose [Saccharomyces cerevisiae S288C],5UW4_A Chain A, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW4_B Chain B, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW4_C Chain C, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW4_D Chain D, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5VNC_A Chain A, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5VNC_B Chain B, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5VNC_C Chain C, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5VNC_D Chain D, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C]
4KQM_A 2.99e-287 329 951 35 676
Crystal structure of yeast glycogen synthase E169Q mutant in complex with glucose and UDP [Saccharomyces cerevisiae FostersO],4KQM_B Crystal structure of yeast glycogen synthase E169Q mutant in complex with glucose and UDP [Saccharomyces cerevisiae FostersO],4KQM_C Crystal structure of yeast glycogen synthase E169Q mutant in complex with glucose and UDP [Saccharomyces cerevisiae FostersO],4KQM_D Crystal structure of yeast glycogen synthase E169Q mutant in complex with glucose and UDP [Saccharomyces cerevisiae FostersO]

Swiss-Prot Hits      download full data without filtering help

Created with Snap4896145193242290338387435484532580629677726774822871919329966sp|O93869|GYS_NEUCR329954sp|P23337|GYS1_YEAST329951sp|P27472|GYS2_YEAST329950sp|P13807|GYS1_HUMAN329950sp|A2RRU1|GYS1_RAT
Hit ID E-Value Query Start Query End Hit Start Hit End Description
sp|O93869|GYS_NEUCR 1.51e-312 329 966 22 653
Glycogen [starch] synthase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) OX=367110 GN=gsy-1 PE=2 SV=2
sp|P23337|GYS1_YEAST 1.47e-295 329 954 16 660
Glycogen [starch] synthase isoform 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=GSY1 PE=1 SV=3
sp|P27472|GYS2_YEAST 1.94e-287 329 951 16 657
Glycogen [starch] synthase isoform 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=GSY2 PE=1 SV=3
sp|P13807|GYS1_HUMAN 4.93e-246 329 950 35 646
Glycogen [starch] synthase, muscle OS=Homo sapiens OX=9606 GN=GYS1 PE=1 SV=2
sp|A2RRU1|GYS1_RAT 1.02e-245 329 950 35 646
Glycogen [starch] synthase, muscle OS=Rattus norvegicus OX=10116 GN=Gys1 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI CS Position
1.000097 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in QSL66238.1.