CAZyme Information: QEL60276.1

Basic Information

• Species: [Candida] auris
• Lineage: Ascomycota; Saccharomycetes; ; Debaryomycetaceae; Candida; [Candida] auris
• CAZyme ID: QEL60276.1
• CAZy Family: GH76
• CAZyme Description: unspecified product

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1441	CP043443|CGC12	165155.13	5.6829

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_CaurisB11245	5675	N/A	169	5506

• Gene Location: location=CP043443:836101-840426(+)

Full Sequence      

MLAHIWLCILVVSASSVSVKLHADWPEAPFALQLIEAVSSYNESLYAQAVRALYQRETEA
DDWDEDDEEGFEANQEDEGEQAALTDKSYYEAVTENLSPVAKGMVDLNLVNKIYTPRIVA
HYKHYEREVEPSLGSIEKQCAKDSFGNEITDPSASWVKYGNKIYCSDADLYALQLSKVSE
KTLEFDRVVGEASKKPLLVLYGAPESPRFQSMFETLYQFSSSDKLRFTWRYVPSEGYKDR
ASIPGYGAVITPKQALNGTKKNSKVKYNGDLSKFLADVKKEGKPLRALDSDEYHDLSVKI
TALILEQPWSARYGLLEEILNNFPLYAPYLKLINNPVNFETVKSVAKSNEKKGASEDSVG
LYLNGASVHKLEMDLPHVVKKLKTEVDLIHKMNMLGFTTEQSKLLFSKYALMSAFKEVQY
RSGDRENRYAIYKHEYDASDPSSGGLVYFNNIEKDDPYDLYDINRKEAYLGREASMLQFG
QVPPLKENAHELVFAIHFSSSIQVKVFFTFAKIILDRNLPQQVGVIPLVESDEDEKVAEK
FYHILSVSDAKEAFALLYQYYEAGTEAEKQAVLDKVEVSEESKGKFKNYKRTVREFSLDA
PSVIVNGVIHDMKSPWQTAMTKQMGNDVRLLQQRIRNGDDTGKSLKAVLFQDSKDSRNSR
VSPKDLSNIRYKEISSNLLENSYSFKKINKPNDAPGTFWLIGDFNSKIILSQFAKLLDVL
ETYEDKSLEIRVFSISEDNSLLINFFNKYGKAPLTDHSIEKLRAETLKAKSKVYTKISPS
QAKLLEQHQIQLHQAGMLFNSRYFKLTEVFEPKELIELIEFEQRRRLSIFKDLTDAYPDI
FRWKGIMHFKKSGYDDFAWFDLVSSVVARSFFLEDSQFQADVDRFDFSSLDFSNALNITD
QNPMKFVDVLAFVNPFTDASQKIVSIVKSLKDLSFVNVQILMQPLEAVPESKSVDRFYSS
AFETSLPRFNDQGAFVGSCHAAGFDALVSSTKYSSELDTPSRWLHVKDSIGDLDHDEFEP
DSVHELNYTLDSLIVEGYAKDVKTAQSIATLTLEVTNGEAVFDAIVMHTLGYVQFQLKPD
VWNLEIQKGSKGRQIYNLLSASDNKYDTNDLPLEHTELGVFSLHGSVIHPRLQEKSEKEI
ARAKKEVLVAKNADVNVFSLASGKLYERFLSTMMVSVKKHTKSTVKFWLLRNFLSAEFVN
RLPILADNYGFEYEFVSYKWPLWLRQQNEKFRQVWGYKILFLDVLFPNQLEKVIFVDADQ
IARADLQELVDTDLKGKVYGFPPMCDSREETEGYRFWKQGYWKNVLKNDLVYHISALFVV
DLKQFRMHYAGDRLRTHYQKLSSDKDSLANLDQDLPNNMQRSIPIHTLHQDWLWCETWCS
DETKDRAKMIDLCSDPFRKGGKLERVQRSIPEWVHYDAEIQRLQKNGLENGSTANVPHDE
L

Enzyme Prediction     

EC	2.4.1.-:29

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT24	1155	1403	4.6e-116	0.9959677419354839

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
408203	Glyco_transf_24	2.03e-175	1155	1423	1	268	Glucosyltransferase 24. This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
133054	GT8_HUGT1_C_like	3.08e-143	1155	1403	1	248	The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family. C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
132996	Glyco_transf_8	5.63e-49	1156	1396	2	241	Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.
408201	Thioredoxin_14	8.12e-32	436	641	1	228	Thioredoxin-like domain. This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
408199	Thioredoxin_12	2.26e-31	29	236	3	181	Thioredoxin-like domain. This is one of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QEL60276.1|GT24	0.0	1	1441	1	1441
QWW23236.1|GT24	0.0	1	1441	2	1442
QRG38164.1|GT24	0.0	1	1441	1	1441
QEO20323.1|GT24	0.0	1	1441	1	1441
QWU89367.1|GT24	0.0	11	1441	9	1426

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5MU1_A	9.69e-148	11	1429	5	1453	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5MZO_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TRF_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
5NV4_A	9.69e-148	11	1429	5	1453	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
6TRT_A	9.21e-147	11	1429	5	1453	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
6TS2_A	1.38e-125	910	1429	659	1219	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_C Chain C, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_D Chain D, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
6TS8_A	2.55e-118	16	1365	3	1382	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS8_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q09140|UGGG_SCHPO	7.62e-135	179	1420	150	1421	UDP-glucose:glycoprotein glucosyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gpt1 PE=1 SV=2
sp|Q9NYU2|UGGG1_HUMAN	9.07e-120	85	1424	94	1524	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3
sp|Q9JLA3|UGGG1_RAT	1.90e-118	85	1424	94	1524	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Uggt1 PE=1 SV=2
sp|Q6P5E4|UGGG1_MOUSE	2.58e-118	85	1424	94	1524	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Mus musculus OX=10090 GN=Uggt1 PE=1 SV=4
sp|Q9NYU1|UGGG2_HUMAN	2.81e-117	11	1441	29	1516	UDP-glucose:glycoprotein glucosyltransferase 2 OS=Homo sapiens OX=9606 GN=UGGT2 PE=1 SV=4

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000307	0.999667	CS pos: 16-17. Pr: 0.8568

TMHMM  Annotations     

There is no transmembrane helices in QEL60276.1.