CAZyme Information: PWY80584.1

Basic Information

• Species: Aspergillus heteromorphus
• Lineage: Ascomycota; Eurotiomycetes; ; Aspergillaceae; Aspergillus; Aspergillus heteromorphus
• CAZyme ID: PWY80584.1
• CAZy Family: PL4
• CAZyme Description: Glyco_trans_2-like domain-containing protein [Source:UniProtKB/TrEMBL;Acc:A0A317W1Y2]

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
585		65102.64	7.4638

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_AheteromorphusCBS117.55	11436	1448321	306	11130

• Gene Location: location=MSFL01000014:274599-276618(+)

Full Sequence      

MDSSVFHARGPEVSRLRQFLNFLGCILILPVYYILTAYTRHPLTLDVLVTIFAAEYNRYT
NECRRRKLYGQDKALQDAEKAIPRLSPAGPGPDCMAAVVGYREDPALFARALESYNSAEG
CRFVLVGIDGDEEADMEMVRVFQKVYSNNTSSVIRLDEPFGELAVRTFDKISTADLHSQP
TDKYMQESIAHCCNLAREILTDHKITFDRGAGGITRLCLYQPHLHKKGIMFTSFIFSIVI
SDLLGIEYLWSSDSDTIVFPRSLRSTVETVAGDPSVGGGSAGLIVHNEHDSAISKLGSVV
YWCELYLTRSTATAAGTSDCQSGPSSAFRVAALPAVLYPWYTQCVLGHRMIINEDRHLTT
NLLLQNWTITYVSDTLASTDTPTTLSKWLLQQVRWSRAGHIESFQNPHIYTLTSPLFFWA
AIKRELGPLLGLAYILYYYVTGTSMAYFSWTDLAFRVVYTIVYNVGRNPDRAGGGKRGIA
WWGWVLPAMVFYNVPLPAVHAWSLGTVFEGGWGTAMRGVSEKEGRMWKRIRELGFFVLWM
GVVGGVMGRIAAGFLGASPETTVRALGWGTTVFSGAAFYGLVVRE

Enzyme Prediction     

No EC number prediction in PWY80584.1.

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
133056	GT2_HAS	2.10e-18	218	399	57	232	Hyaluronan synthases catalyze polymerization of hyaluronan. Hyaluronan synthases (HASs) are bi-functional glycosyltransferases that catalyze polymerization of hyaluronan. HASs transfer both GlcUA and GlcNAc in beta-(1,3) and beta-(1,4) linkages, respectively to the hyaluronan chain using UDP-GlcNAc and UDP-GlcUA as substrates. HA is made as a free glycan, not attached to a protein or lipid. HASs do not need a primer for HA synthesis; they initiate HA biosynthesis de novo with only UDP-GlcNAc, UDP-GlcUA, and Mg2+. Hyaluronan (HA) is a linear heteropolysaccharide composed of (1-3)-linked beta-D-GlcUA-beta-D-GlcNAc disaccharide repeats. It can be found in vertebrates and a few microbes and is typically on the cell surface or in the extracellular space, but is also found inside mammalian cells. Hyaluronan has several physiochemical and biological functions such as space filling, lubrication, and providing a hydrated matrix through which cells can migrate.
224136	BcsA	2.17e-14	253	579	145	430	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility].
133043	CESA_CelA_like	3.89e-06	253	404	92	234	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose. Family of proteins related to Agrobacterium tumefaciens CelA and Gluconacetobacter xylinus BscA. These proteins are involved in the elongation of the glucan chain of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues. They are putative catalytic subunit of cellulose synthase, which is a glycosyltransferase using UDP-glucose as the substrate. The catalytic subunit is an integral membrane protein with 6 transmembrane segments and it is postulated that the protein is anchored in the membrane at the N-terminal end.
133033	Chitin_synth_C	2.47e-05	253	395	81	237	C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin. Chitin synthase, also called UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyltransferase, catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of GlcNAc residues formed by covalent beta-1,4 linkages. Chitin is an important component of the cell wall of fungi and bacteria and it is synthesized on the cytoplasmic surface of the cell membrane by membrane bound chitin synthases. Studies with fungi have revealed that most of them contain more than one chitin synthase gene. At least five subclasses of chitin synthases have been identified.
367353	Chitin_synth_2	9.05e-05	247	395	203	370	Chitin synthase. Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyze chitin synthesis as follows: UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QMW26501.1|GT2	9.67e-267	5	584	14	588
QRD87385.1|GT2	9.67e-267	5	584	14	588
QMW38580.1|GT2	9.67e-267	5	584	14	588
BAE55426.1|GT2	9.67e-267	5	584	14	588
UCK59072.1|GT2	9.67e-267	5	584	14	588

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7SP7_A	4.37e-23	98	543	89	488	Chain A, Hyaluronan synthase [Paramecium bursaria Chlorella virus CZ-2]
7SP6_A	1.83e-22	98	543	89	488	Chain A, Hyaluronan synthase [Paramecium bursaria Chlorella virus CZ-2],7SP8_A Chain A, Hyaluronan synthase [Paramecium bursaria Chlorella virus CZ-2],7SP9_A Chain A, Hyaluronan synthase [Paramecium bursaria Chlorella virus CZ-2],7SPA_A Chain A, Hyaluronan synthase [Paramecium bursaria Chlorella virus CZ-2]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q92839|HYAS1_HUMAN	3.04e-21	98	446	101	430	Hyaluronan synthase 1 OS=Homo sapiens OX=9606 GN=HAS1 PE=1 SV=2
sp|Q61647|HYAS1_MOUSE	5.34e-20	98	517	105	498	Hyaluronan synthase 1 OS=Mus musculus OX=10090 GN=Has1 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
1.000016	0.000003

TMHMM  Annotations     

Start	End
20	39
426	448
535	557
561	583