CAZyme Information: PV06_10424-t43_1-p1

Basic Information

• Species: Exophiala oligosperma
• Lineage: Ascomycota; Eurotiomycetes; ; Herpotrichiellaceae; Exophiala; Exophiala oligosperma
• CAZyme ID: PV06_10424-t43_1-p1
• CAZy Family: GT34
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1486	KN847344.1|CGC5	166443.77	4.9262

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_EoligospermaCBS72588	11938	N/A	45	11893

• Gene Location: location=KN847344.1:183271-187787(-)

Full Sequence      

MQLPRLLQNSVAGGLLCAALFTPLTGASPSINVALETSFSAAPYLVELLETAALENSSSY
FPLLDRIADGAFVDLQTEKELYNKFIEVLQQDGHLSNPESLSSFKFALALHAAAPRVEAH
FQYYNHSVQPHLMAAQDAACPVWVYLDGQQYCSPALDRAQQPVSMPEAEGELPFDRVLGS
DVDGPHSILYADITHPLFGQFHSIVSQTAREGRSTYRLRYRPSTLSARKPLYVSGYGVEL
VLKRTDYIVIDDRDAQKSEASKPEQISLQQAQDDDLTDLKPLTSSEVVSLSVNAASLIAS
SPDPLERLLQITCDFPRYSSVLASTNASKEFLAEHRANREQFLPSGYNVFWINGVQIEAR
HINAYSLLEHLRRERRIIGDLQKIGLAPSEAVSLMSSEVIAETQANESPQRFDWRDDLEE
NKVLMWLNDLEQDKRYAGWPSSLRALFARVYPGQLPQVARDIHNLVVPIDMTDVKDIELV
TTALQNLVKRSVPIRVALVPTGTGAVADIYSKLSYHILDTYGLGTLMSFFTEIASSKKLP
ASPEKAFTTAIKGRSLREGKEVTPYEGILQAEPLDAKLKARDAYVKRLALGSANRPFVVN
GVVLPRSENWFEVLSSRVFSDLQLLQQAIYEGAIEEEGWIPGILLFSAAARRNELVFPSD
PKNVEIVDINRLTNDFANEFAALPRILGNAATLLSDRAHVFVIADLSTAAGRAFLQQALD
FWEAHPEADLLILHNPLPDSELHSVASGLHALTQHGRDLTVEQVRTLLEQDTILPEGEEE
AGRFWASYWGLLNQVGLEMGQNGLWLNGRVIAPVDDSFMATDFESLLEYERRERMAPVTT
AITSLGLEERFGDALDLAKVTSLVARSLKSDLPEGLRESAPLIRMDRFKIWNDTHTSFKI
SNGDNPTIQVVAVVDPASEVVQQWVPILKTLSHLSGVSVKIFLNPKDRLAELPVKRFYRQ
VVSSEPTFDSEGSLQEPTASFQRIPRDILFNLGMTVPPSWLVAPKECTYDLDNIKLSSVA
DGDNIDAVYELEHILIEGHARDVTTGPPPRGVQLLLGTEQEPHFTDTIIMANLGYFQFKA
NPGFWHITLKPGRSSKIFSIDSVGPQGYAAQPDDETTSVALLSFQGATLFPRLSRKPGME
DEDVLEASGGAMDYLNKGASFASSALSSLGLKTKSSNNADINIFSVASGHLYERMLNIMM
VSVMKHTKHTVKFWFIEQFLSPSFKSTLPDMAEHYGFDYEMVTYKWPHWLRGQKEKQREI
WGYKILFLDVLFPLDLDKVIFVDADQIVRTDMMELNKVDLKGAPYGFTPMCDSRTEMEGF
RFWKQGYWETYLRGKPYHISALYVVDLKRFRQLAAGDRLRQQYQALSSDPNSLSNLDQDL
PNHMQHVLPIHSLSQEWLWCETWCSDESLGVAKTIDLCNNPLTKEPKLDRARRQVPEWTE
YDEEIASVLKEAAGKRSSRQLPEVDEVAGKKEDIVAADDERKRDEL

Enzyme Prediction     

EC	2.4.1.-:29

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT24	1181	1428	7.8e-134	0.9959677419354839

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
133054	GT8_HUGT1_C_like	0.0	1181	1428	1	248	The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family. C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
408203	Glyco_transf_24	0.0	1181	1448	1	268	Glucosyltransferase 24. This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
408201	Thioredoxin_14	5.16e-85	412	656	1	248	Thioredoxin-like domain. This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
399437	UDP-g_GGTase	5.89e-66	1037	1146	1	109	UDP-glucose:Glycoprotein Glucosyltransferase. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER.
408199	Thioredoxin_12	9.54e-61	41	229	1	185	Thioredoxin-like domain. This is one of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
UDD64319.1|GT24	0.0	18	1480	18	1486
CAK39488.1|GT24	0.0	27	1463	28	1470
CAS97678.1|GT24	0.0	27	1463	28	1470
BAE65008.1|GT24|2.4.1.-	0.0	18	1480	18	1486
CAP81259.1|GT24	0.0	24	1458	25	1466

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5MU1_A	0.0	22	1450	2	1449	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5MZO_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TRF_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
5NV4_A	0.0	22	1450	2	1449	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
5Y7O_A	0.0	26	1146	1	1124	Crystal structure of folding sensor region of UGGT from Thermomyces dupontii [Thermomyces dupontii],5Y7O_B Crystal structure of folding sensor region of UGGT from Thermomyces dupontii [Thermomyces dupontii]
6TRT_A	0.0	22	1450	2	1449	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
6TS2_A	0.0	22	1450	2	1215	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_C Chain C, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_D Chain D, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q09140|UGGG_SCHPO	1.43e-291	18	1465	10	1440	UDP-glucose:glycoprotein glucosyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gpt1 PE=1 SV=2
sp|Q09332|UGGG_DROME	9.31e-236	19	1449	15	1508	UDP-glucose:glycoprotein glucosyltransferase OS=Drosophila melanogaster OX=7227 GN=Uggt PE=1 SV=2
sp|Q9JLA3|UGGG1_RAT	6.77e-231	11	1445	29	1520	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Uggt1 PE=1 SV=2
sp|Q6P5E4|UGGG1_MOUSE	1.33e-230	20	1445	36	1520	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Mus musculus OX=10090 GN=Uggt1 PE=1 SV=4
sp|Q9NYU2|UGGG1_HUMAN	7.88e-230	20	1445	36	1520	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.029545	0.970412	CS pos: 27-28. Pr: 0.8526

TMHMM  Annotations     

There is no transmembrane helices in PV06_10424-t43_1-p1.