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CAZyme Information: PSURA_85409T0-p1

You are here: Home > Sequence: PSURA_85409T0-p1

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Phytophthora ramorum
Lineage Oomycota; NA; ; Peronosporaceae; Phytophthora; Phytophthora ramorum
CAZyme ID PSURA_85409T0-p1
CAZy Family GT71
CAZyme Description N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
1361 PramPr-102_SC0180|CGC1 154094.54 5.9385
Genome Property
Genome Version/Assembly ID Genes Strain NCBI Taxon ID Non Protein Coding Genes Protein Coding Genes
FungiDB-61_PramorumPr-102 15743 N/A 251 15492
Gene Location

Full Sequence      Download help

Enzyme Prediction      help

EC 3.2.1.8:31

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH10 37 335 2.7e-83 0.9438943894389439

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
223956 Ptr 0.0 377 1317 13 928
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones].
185056 PRK15101 3.16e-98 378 1281 34 918
protease3; Provisional
395262 Glyco_hydro_10 1.04e-96 36 352 1 308
Glycosyl hydrolase family 10.
406571 Peptidase_M16_M 1.93e-88 748 1033 1 283
Middle or third domain of peptidase_M16. Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
214750 Glyco_10 6.51e-80 81 352 1 263
Glycosyl hydrolase family 10.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
4.02e-200 2 358 1 355
9.80e-184 6 357 5 358
4.87e-160 1 357 1 355
4.29e-156 1 357 1 353
1.54e-127 15 356 12 350

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1.60e-204 378 1349 9 955
Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin [Homo sapiens],6B70_B Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin [Homo sapiens],6B7Y_A Cryo-EM structure of human insulin degrading enzyme [Homo sapiens],6B7Y_B Cryo-EM structure of human insulin degrading enzyme [Homo sapiens],6B7Z_A Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain and FAB H11 light chain [Homo sapiens],6B7Z_B Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain and FAB H11 light chain [Homo sapiens],6BF6_A Cryo-EM structure of human insulin degrading enzyme [Homo sapiens],6BF6_B Cryo-EM structure of human insulin degrading enzyme [Homo sapiens],6BF7_A Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain [Homo sapiens],6BF7_B Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain [Homo sapiens],6BF8_A Cryo-EM structure of human insulin degrading enzyme in complex with insulin [Homo sapiens],6BF8_B Cryo-EM structure of human insulin degrading enzyme in complex with insulin [Homo sapiens],6BF9_A Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain [Homo sapiens],6BF9_B Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain [Homo sapiens],6BFC_A Cryo-EM structure of human insulin degrading enzyme in complex with insulin [Homo sapiens],6BFC_B Cryo-EM structure of human insulin degrading enzyme in complex with insulin [Homo sapiens]
1.66e-204 378 1349 25 971
Chain A, Insulin-degrading enzyme [Homo sapiens],2G47_B Chain B, Insulin-degrading enzyme [Homo sapiens],2G48_A Chain A, Insulin-degrading enzyme [Homo sapiens],2G48_B Chain B, Insulin-degrading enzyme [Homo sapiens],2G49_A Chain A, Insulin-degrading enzyme [Homo sapiens],2G49_B Chain B, Insulin-degrading enzyme [Homo sapiens],2G54_A Chain A, Insulin-degrading enzyme [Homo sapiens],2G54_B Chain B, Insulin-degrading enzyme [Homo sapiens],2G56_A Chain A, Insulin-degrading enzyme [Homo sapiens],2G56_B Chain B, Insulin-degrading enzyme [Homo sapiens],2JBU_A Crystal structure of human insulin degrading enzyme complexed with co- purified peptides. [Homo sapiens],2JBU_B Crystal structure of human insulin degrading enzyme complexed with co- purified peptides. [Homo sapiens],3E50_A Chain A, Insulin-degrading enzyme [Homo sapiens],3E50_B Chain B, Insulin-degrading enzyme [Homo sapiens]
2.33e-204 378 1349 25 971
Substrate-free IDE structure in its closed conformation [Homo sapiens],2JG4_B Substrate-free IDE structure in its closed conformation [Homo sapiens]
6.46e-204 378 1349 25 971
Chain A, Insulin-degrading enzyme [Homo sapiens],3E4Z_B Chain B, Insulin-degrading enzyme [Homo sapiens]
1.27e-203 378 1295 25 933
The structure of cysteine-free human insulin degrading enzyme [Homo sapiens],3QZ2_B The structure of cysteine-free human insulin degrading enzyme [Homo sapiens],4DTT_A Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367 [Homo sapiens],4DTT_B Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367 [Homo sapiens],4IFH_A Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619 [Homo sapiens],4IFH_B Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619 [Homo sapiens],4IOF_A Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE) [Homo sapiens],4IOF_B Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE) [Homo sapiens],4RE9_A Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 71290 [Homo sapiens],4RE9_B Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 71290 [Homo sapiens],5UOE_A Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) [Homo sapiens],5UOE_B Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) [Homo sapiens],5UOE_C Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) [Homo sapiens],5UOE_D Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) [Homo sapiens],5UOE_E Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) [Homo sapiens],6B3Q_A Cryo-EM structure of human insulin degrading enzyme in complex with insulin [Homo sapiens],6B3Q_B Cryo-EM structure of human insulin degrading enzyme in complex with insulin [Homo sapiens],7K1D_A Chain A, Insulin-degrading enzyme [Homo sapiens],7K1D_B Chain B, Insulin-degrading enzyme [Homo sapiens],7K1E_A Chain A, Insulin-degrading enzyme [Homo sapiens],7K1E_B Chain B, Insulin-degrading enzyme [Homo sapiens],7K1F_A Chain A, Insulin-degrading enzyme [Homo sapiens],7K1F_B Chain B, Insulin-degrading enzyme [Homo sapiens]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
5.16e-204 384 1349 60 1000
Insulin-degrading enzyme OS=Bos taurus OX=9913 GN=IDE PE=2 SV=1
7.25e-204 378 1349 54 1000
Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4
3.03e-202 376 1349 52 1000
Insulin-degrading enzyme OS=Rattus norvegicus OX=10116 GN=Ide PE=1 SV=1
6.90e-200 376 1349 52 1000
Insulin-degrading enzyme OS=Mus musculus OX=10090 GN=Ide PE=1 SV=1
3.56e-182 383 1291 69 965
A-factor-processing enzyme OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=STE23 PE=1 SV=2

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI CS Position
0.000253 0.999714 CS pos: 20-21. Pr: 0.9592

TMHMM  Annotations      help

There is no transmembrane helices in PSURA_85409T0-p1.