CAZyme Information: PMAA_017980-t26_1-p1

Basic Information

• Species: Talaromyces marneffei
• Lineage: Ascomycota; Eurotiomycetes; ; Trichocomaceae; Talaromyces; Talaromyces marneffei
• CAZyme ID: PMAA_017980-t26_1-p1
• CAZy Family: CBM66|CBM66
• CAZyme Description: mannosyl-oligosaccharide glucosidase, putative

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
818		92944.68	4.5791

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_TmarneffeiATCC18224	10194	441960	145	10049

• Gene Location: location=DS995899:711105-713774(-)

Full Sequence      

MHIQFSSYLLWSSFALGCAYATNDVSVLINEAARANNQSLLWGPYKSNLYFGVRPRIPKS
LTAGLMWAKVDDYATAQANFRHTCEQNEGMRGYGWDEYDVRRGGRQSIHDVGNSIDLTID
FVKVPGGLHGGSWAARVKGTPREDAPEDLYTSMVFYASLEGLGSLHVDNAVEQQIGLKED
VRLKGMTPELGDFTLSVTTGPESNSHPQFDHPSGAEKPLNRPLIASVETPPDNLWQAKAL
MFTAMKPEVEGLLAKYGTDAPPPPAQLFTLPNHPGAGNIHFVQYVFEGAFEFDILFESGS
ASEPVTSETLTKKIDEMSSSFSSQYENIFAPQPPFDKAEYLEFSKSMFSNLVGGIGYFYG
SGLVDRSEAPEYEEENEGFWEEAAEARSRVQPTEEDPHELFTCIPSRPFFPRGFLWDEGF
HLIPVVDWDLDLTLDIVQSWFNLMDEDGWIAREQILGAEARSKVPAEFTVQYPHYANPPT
LFMVLEAFVDKLQANQSIVENSELNRADIADSLRSAHLESKELAESYLHSIYPLLRRQYS
WFKKTQWGDVKSYDREAYSSKEAYRWRGRTVRHILTSGLDDYPRAQPPHPGELHTDLISW
MGLMSRSLRKIAAAIGETEDADEFAIYEYAITRNIEDLHWDEDAQTWCDATIDEYEESVH
VCHKGYISIFPFLTGMVGPDSPHLKATLDLIRNSNELWSDYGIRSLSKNDEFYSTDENYW
RSPVWINMNYMILKNLYDIASSQSSHKAQAAEIYNDLRKNLVENVFREWKDTGFAWEQYN
PETGKGQRTQHFTGWTSLVVKIMNMPYLTGAERGHDEL

Enzyme Prediction     

EC	3.2.1.106:25	3.2.1.-:4

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH63	593	804	7.3e-32	0.43157894736842106

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
397353	Glyco_hydro_63	0.0	306	805	2	494	Glycosyl hydrolase family 63 C-terminal domain. This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the C-terminal catalytic domain.
407154	Glyco_hydro_63N	2.26e-124	40	263	1	221	Glycosyl hydrolase family 63 N-terminal domain. This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the N-terminal beta sandwich domain.
225942	GDB1	2.38e-06	667	737	485	549	Glycogen debranching enzyme (alpha-1,6-glucosidase) [Carbohydrate transport and metabolism].
215307	PLN02567	4.88e-04	596	800	329	537	alpha,alpha-trehalase

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QGA12606.1|GH63	0.0	1	818	1	818
QKX57094.1|GH63	0.0	15	818	445	1253
QRD84190.1|GH63	0.0	1	818	1	817
UDD57712.1|GH63	0.0	1	818	1	817
BCS02288.1|GH63	0.0	23	818	27	822

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4J5T_A	1.49e-161	29	803	4	800	Crystal structure of Processing alpha-Glucosidase I [Saccharomyces cerevisiae S288C]
5MHF_A	2.43e-130	40	807	37	779	Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus],5MHF_B Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus],5MHF_C Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus],5MHF_D Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|O14255|GCS1_SCHPO	8.70e-240	13	807	19	808	Probable mannosyl-oligosaccharide glucosidase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC6G10.09 PE=3 SV=1
sp|P53008|CWH41_YEAST	2.37e-162	4	803	8	830	Mannosyl-oligosaccharide glucosidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CWH41 PE=1 SV=1
sp|Q80UM7|MOGS_MOUSE	7.75e-132	40	807	92	834	Mannosyl-oligosaccharide glucosidase OS=Mus musculus OX=10090 GN=Mogs PE=1 SV=1
sp|O88941|MOGS_RAT	3.67e-128	42	807	94	834	Mannosyl-oligosaccharide glucosidase OS=Rattus norvegicus OX=10116 GN=Mogs PE=1 SV=1
sp|Q13724|MOGS_HUMAN	1.48e-122	40	807	94	837	Mannosyl-oligosaccharide glucosidase OS=Homo sapiens OX=9606 GN=MOGS PE=1 SV=5

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.006608	0.993355	CS pos: 21-22. Pr: 0.9304

TMHMM  Annotations     

There is no transmembrane helices in PMAA_017980-t26_1-p1.