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CAZyme Information: PHYCI_226710T0-p1
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Phytophthora cinnamomi | |||||||||||
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| Lineage | Oomycota; NA; ; Peronosporaceae; Phytophthora; Phytophthora cinnamomi | |||||||||||
| CAZyme ID | PHYCI_226710T0-p1 | |||||||||||
| CAZy Family | GH12 | |||||||||||
| CAZyme Description | unspecified product | |||||||||||
| CAZyme Property |
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| Genome Property |
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Enzyme Prediction help
| EC | 2.4.1.257:6 | 2.4.1.132:6 |
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CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| 340834 | GT4_ALG2-like | 3.60e-178 | 1152 | 1543 | 1 | 392 | alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans. |
| 399535 | Myotub-related | 1.46e-169 | 706 | 1034 | 8 | 330 | Myotubularin-like phosphatase domain. This family represents the phosphatase domain within eukaryotic myotubularin-related proteins. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associated with disease. |
| 350357 | PTP-MTM-like | 1.62e-118 | 764 | 994 | 1 | 226 | protein tyrosine phosphatase-like domain of myotubularins. Myotubularins are a unique subgroup of protein tyrosine phosphatases that use inositol phospholipids, rather than phosphoproteins, as substrates. They dephosphorylate the D-3 position of phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2], generating phosphatidylinositol and phosphatidylinositol 5-phosphate [PI(5)P], respectively. Not all members are catalytically active proteins, some function as adaptors for the active members. |
| 350380 | PTP-MTMR6-like | 1.94e-113 | 708 | 1019 | 1 | 301 | protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatases 6, 7, and 8. This subgroup of enzymatically active phosphatase domains of myotubularins consists of MTMR6, MTMR7 and MTMR8, and related domains. Beside the phosphatase domain, they contain a C-terminal coiled-coil domain and an N-terminal PH-GRAM domain. In general, myotubularins are a unique subgroup of protein tyrosine phosphatases that use inositol phospholipids, rather than phosphoproteins, as substrates. They dephosphorylate the D-3 position of phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2], generating phosphatidylinositol and phosphatidylinositol 5-phosphate [PI(5)P], respectively. MTMR6, MTMR7 and MTMR8 form complexes with catalytically inactive MTMR9, and display differential substrate preferences. In cells, the MTMR6/R9 complex significantly increases the cellular levels of PtdIns(5)P, the product of PI(3,5)P(2) dephosphorylation, whereas the MTMR8/R9 complex reduces cellular PtdIns(3)P levels. The MTMR6/R9 complex serves to inhibit stress-induced apoptosis while the MTMR8/R9 complex inhibits autophagy. |
| 350383 | PTP-MTM1-like | 2.65e-90 | 765 | 1018 | 2 | 249 | protein tyrosine phosphatase-like domain of myotubularin, and myotubularin related phosphoinositide phosphatases 1 and 2. This subgroup of enzymatically active phosphatase domains of myotubularins consists of MTM1, MTMR1 and MTMR2. All contain an additional N-terminal PH-GRAM domain and C-terminal coiled-coiled domain and PDZ binding site. In general, myotubularins are a unique subgroup of protein tyrosine phosphatases that use inositol phospholipids, rather than phosphoproteins, as substrates. They dephosphorylate the D-3 position of phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2], generating phosphatidylinositol and phosphatidylinositol 5-phosphate [PI(5)P], respectively. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| 4.64e-276 | 1105 | 1557 | 1 | 453 | |
| 4.10e-153 | 1113 | 1549 | 8 | 447 | |
| 6.52e-105 | 1151 | 1552 | 2 | 404 | |
| 4.47e-103 | 1153 | 1543 | 4 | 397 | |
| 9.60e-103 | 1151 | 1548 | 11 | 407 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 7.31e-106 | 542 | 1102 | 73 | 599 | Chain A, Myotubularin-related protein 2 [Homo sapiens],1M7R_A Chain A, Myotubularin-related Protein-2 [Homo sapiens],1M7R_B Chain B, Myotubularin-related Protein-2 [Homo sapiens] |
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| 2.17e-105 | 542 | 1091 | 1 | 516 | Chain A, Myotubularin-related protein 2 [Homo sapiens],1ZVR_A Chain A, Myotubularin-related protein 2 [Homo sapiens] |
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| 2.95e-105 | 547 | 1102 | 3 | 524 | Myotubularin-related protein 2 [Homo sapiens],5GNH_B Myotubularin-related protein 2 [Homo sapiens] |
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| 9.82e-101 | 580 | 1098 | 29 | 519 | Myotubularin-related proetin 1 [Homo sapiens],5C16_B Myotubularin-related proetin 1 [Homo sapiens],5C16_C Myotubularin-related proetin 1 [Homo sapiens],5C16_D Myotubularin-related proetin 1 [Homo sapiens] |
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| 2.17e-94 | 650 | 1092 | 68 | 505 | Human Myotubularin related protein 6 (MTMR6) [Homo sapiens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2.23e-107 | 542 | 1102 | 70 | 596 | Myotubularin-related protein 2 OS=Bos taurus OX=9913 GN=MTMR2 PE=2 SV=1 |
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| 1.09e-106 | 542 | 1102 | 70 | 596 | Myotubularin-related protein 2 OS=Homo sapiens OX=9606 GN=MTMR2 PE=1 SV=4 |
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| 2.38e-106 | 580 | 1093 | 59 | 545 | Myotubularin OS=Pongo abelii OX=9601 GN=MTM1 PE=2 SV=1 |
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| 2.38e-106 | 580 | 1093 | 59 | 545 | Myotubularin OS=Homo sapiens OX=9606 GN=MTM1 PE=1 SV=2 |
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| 3.85e-106 | 542 | 1102 | 70 | 596 | Myotubularin-related protein 2 OS=Mus musculus OX=10090 GN=Mtmr2 PE=1 SV=3 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | CS Position |
|---|---|---|
| 1.000092 | 0.000000 |
