CAZyme Information: PHYCI_217260T0-p1

Basic Information

• Species: Phytophthora cinnamomi
• Lineage: Oomycota; NA; ; Peronosporaceae; Phytophthora; Phytophthora cinnamomi
• CAZyme ID: PHYCI_217260T0-p1
• CAZy Family: GH1
• CAZyme Description: Beta-1,4-mannosyltransferase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
653		72770.30	10.8914

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_PcinnamomiCBS144-22	26201	1048749	70	26131

• Gene Location: location=PcinCBS144-22_SC0019:94961-97719(+)

Full Sequence      

MVLGDVGRSPRMQYHALSLARMSPSLRVTLLGYAGETCVPDVARQPNLELLTFTPRLQRL
PRKLFPLLAPVKVLLQLLQLLWLLLVSVGSLDLVLLQNPPTIPTFVVVWLCCRLKGAKFV
IDWHNLGYSLLALSLGGGHPLVKIAKWVERVFGRKADANLCVTHVMQTWLRETWQIEATV
LHDKPPLFFKPTSIETQHELFARVGDQLEHCNDLVTWGGNPSNLEETLLTRKTHGPNGKK
GKSVVLPRENRPAMIISSTSWTADEDFGILLTALELLDKRTSSLSVSEFPNLLVVVTGKG
PQKEMYLEKIRQLAFKRIRIATMWLEASDYPHVLGSADLGVCLHTSSSGLDLPMKVLDMF
GCGLPVCAIGFKCLDELVKHDKNGLVFDSSEQLSTQLFSLLRGYPTDTALLNRLRASLKT
VEVRFSPLHLPSHVHPQFRKPSHISFPNLPYKNLQAFQQLQNRIMATPGGFSLGISPEEK
LSLPLDTLIQKAKKQHKHKPKAADDQKPKKQQKQQPKKAQKTQKKAPTHKQQNVKKTVLV
PVSKAARAKANAAVASAKRQSVINKRRPGLVLAAKKGRKPTVQLRPHKTSAARQKQQQLR
KGGQKPQHGGGLDVSNIINHFRTHPKKFDVPKGSNLRITINLNNVKPVVGGQK

Enzyme Prediction     

EC	2.4.1.142:10	2.4.1.-:1

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT33	1	419	2.4e-154	0.9411764705882353

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
340843	GT33_ALG1-like	1.75e-176	2	419	10	392	chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins. This family is most closely related to the GT33 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and Dol-PP-Glc-NAc2, and participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. In humans ALG1 has been associated with the congenital disorders of glycosylation (CDG) designated as subtype CDG-Ik.
215155	PLN02275	2.33e-171	2	401	11	371	transferase, transferring glycosyl groups
340825	GT4_WbuB-like	3.52e-13	92	426	100	382	Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.
340831	GT4_PimA-like	3.36e-12	92	427	84	354	phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.
223515	RfaB	1.63e-11	1	426	1	362	Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
UIZ21318.1|GT33	0.0	1	653	86	786
CCA25895.1|GT33	2.32e-160	1	421	15	432
CAG7866879.1|GT33	6.35e-130	1	416	11	433
VDC63845.1|GT33	6.35e-130	1	416	11	433
VDD58754.1|GT33	8.83e-129	1	416	11	433

PDB Hits     

PHYCI_217260T0-p1 has no PDB hit.

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q8L7M0|TUN_ARATH	4.68e-126	1	416	10	432	UDP-glycosyltransferase TURAN OS=Arabidopsis thaliana OX=3702 GN=TUN PE=2 SV=1
sp|Q9BT22|ALG1_HUMAN	1.05e-114	1	419	38	442	Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Homo sapiens OX=9606 GN=ALG1 PE=1 SV=2
sp|Q5R7A2|ALG1_PONAB	1.05e-114	1	419	38	442	Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Pongo abelii OX=9601 GN=ALG1 PE=2 SV=1
sp|Q921Q3|ALG1_MOUSE	6.57e-108	1	419	38	442	Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Mus musculus OX=10090 GN=Alg1 PE=1 SV=3
sp|P90522|ALG1_DICDI	9.14e-92	1	407	7	420	Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Dictyostelium discoideum OX=44689 GN=alg1 PE=2 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
0.999944	0.000078

TMHMM  Annotations     

There is no transmembrane helices in PHYCI_217260T0-p1.