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CAZyme Information: PHYBL_95968T0-p1

You are here: Home > Sequence: PHYBL_95968T0-p1

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Phycomyces blakesleeanus
Lineage Mucoromycota; Mucoromycetes; ; Phycomycetaceae; Phycomyces; Phycomyces blakesleeanus
CAZyme ID PHYBL_95968T0-p1
CAZy Family GT50
CAZyme Description Chitin synthase/hyaluronan synthase (glycosyltransferases)
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
1659 PblaNRRL1555-_SC04|CGC7 188578.39 6.6547
Genome Property
Genome Version/Assembly ID Genes Strain NCBI Taxon ID Non Protein Coding Genes Protein Coding Genes
FungiDB-61_PblakesleeanusNRRL1555 16528 763407 0 16528
Gene Location

Full Sequence      Download help

Enzyme Prediction      help

EC 2.4.1.16:11

CAZyme Signature Domains help

Family Start End Evalue family coverage
GT2 1150 1656 7.8e-237 0.9924098671726755

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
367353 Chitin_synth_2 0.0 1148 1655 1 525
Chitin synthase. Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyze chitin synthesis as follows: UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).
276845 MYSc_Myo17 3.73e-173 8 680 1 647
class XVII myosin, motor domain. This fungal myosin which is also known as chitin synthase uses its motor domain to tether its vesicular cargo to peripheral actin. It works in opposition to dynein, contributing to the retention of Mcs1 vesicles at the site of cell growth and increasing vesicle fusion necessary for polarized growth. Class 17 myosins consist of a N-terminal myosin motor domain with Cyt-b5, chitin synthase 2, and a DEK_C domains at it C-terminus. The chitin synthase region contains several transmembrane domains by which myosin 17 is thought to bind secretory vesicles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
214580 MYSc 8.47e-137 1 680 10 674
Myosin. Large ATPases. ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.
276950 MYSc 2.67e-130 11 671 1 633
Myosin motor domain superfamily. Myosin motor domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
395017 Myosin_head 8.54e-112 1 669 3 672
Myosin head (motor domain).

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
0.0 1 1658 13 1689
0.0 1 1658 13 1694
0.0 3 1658 18 1674
0.0 2 1659 14 1757
0.0 2 1659 14 1759

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1.87e-73 2 679 54 735
Crystal structure of myosin X motor domain in pre-powerstroke state [Homo sapiens],5I0H_B Crystal structure of myosin X motor domain in pre-powerstroke state [Homo sapiens]
4.72e-73 2 679 52 733
Crystal structure of myosin X motor domain with 2IQ motifs in pre-powerstroke state [Homo sapiens],5I0I_B Crystal structure of myosin X motor domain with 2IQ motifs in pre-powerstroke state [Homo sapiens]
2.65e-72 2 679 52 733
Rigor myosin X co-complexed with an actin filament [Homo sapiens]
1.34e-68 1 679 73 760
Crystal Structure Of Myosin V Motor Domain - Nucleotide-Free [Gallus gallus],1W8J_B Crystal Structure Of Myosin V Motor Domain - Nucleotide-Free [Gallus gallus],1W8J_C Crystal Structure Of Myosin V Motor Domain - Nucleotide-Free [Gallus gallus],1W8J_D Crystal Structure Of Myosin V Motor Domain - Nucleotide-Free [Gallus gallus]
2.08e-68 1 679 73 760
Chain A, Unconventional myosin-Va [Gallus gallus],7PLU_A Chain A, Unconventional myosin-Va [Gallus gallus],7PLU_D Chain D, Unconventional myosin-Va [Gallus gallus],7PLV_A Chain A, Unconventional myosin-Va [Gallus gallus],7PLW_A Chain A, Unconventional myosin-Va [Gallus gallus],7PLX_A Chain A, Unconventional myosin-Va [Gallus gallus],7PLY_A Chain A, Unconventional myosin-Va [Gallus gallus],7PLZ_A Chain A, Unconventional myosin-Va [Gallus gallus],7PLZ_D Chain D, Unconventional myosin-Va [Gallus gallus],7PM0_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM1_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM2_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM5_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM6_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM6_D Chain D, Unconventional myosin-Va [Gallus gallus],7PM7_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM8_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM9_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMA_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMB_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMC_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMD_A Chain A, Unconventional myosin-Va [Gallus gallus],7PME_A Chain A, Unconventional myosin-Va [Gallus gallus],7PME_D Chain D, Unconventional myosin-Va [Gallus gallus],7PMF_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMG_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMH_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMI_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMJ_A Chain A, Unconventional myosin-Va [Gallus gallus],7PML_A Chain A, Unconventional myosin-Va [Gallus gallus]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
0.0 2 1659 10 1751
Chitin synthase 8 OS=Ustilago maydis (strain 521 / FGSC 9021) OX=237631 GN=CHS8 PE=3 SV=1
0.0 8 1659 21 1739
Chitin synthase 5 OS=Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) OX=235443 GN=CHS5 PE=2 SV=1
2.45e-291 826 1659 69 895
Chitin synthase 6 OS=Ustilago maydis (strain 521 / FGSC 9021) OX=237631 GN=CHS6 PE=3 SV=2
6.70e-269 827 1655 163 989
Chitin synthase 4 OS=Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) OX=235443 GN=CHS4 PE=2 SV=2
2.36e-143 1178 1655 668 1159
Chitin synthase 3 OS=Candida albicans OX=5476 GN=CHS3 PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI CS Position
1.000066 0.000000

TMHMM  Annotations      download full data without filtering help

Start End
830 852
865 884
1134 1156
1533 1555
1560 1582
1589 1611