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CAZyme Information: PABG_05803-t30_1-p1

You are here: Home > Sequence: PABG_05803-t30_1-p1

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Paracoccidioides brasiliensis
Lineage Ascomycota; Eurotiomycetes; ; NA; Paracoccidioides; Paracoccidioides brasiliensis
CAZyme ID PABG_05803-t30_1-p1
CAZy Family GT1
CAZyme Description cysteine desulfurase, mitochondrial
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
979 KN305539|CGC1 107398.98 7.0631
Genome Property
Genome Version/Assembly ID Genes Strain NCBI Taxon ID Non Protein Coding Genes Protein Coding Genes
FungiDB-61_PbrasiliensisPb03 8548 482561 121 8427
Gene Location Start: 1373886; End:1378153  Strand: -

Full Sequence      Download help

MALLPEHKAA  VRSFLSDDEI  LESSSEKYAA  ETTFWSTYKN  PKPHLVLRPK  SLPALQKTVQ60
YLCGLDLDFA  VRSGGNNTAG  AKDVELSMKA  FDSFEYHPES  ETITIGAGQT  WGEVDRKLEE120
AAPGFTVLST  RVPFVGVAGS  LLVGGFSWFS  GEFGLCSDPQ  TLLDAHVVLP  DGRTLWAATE180
PDLLWALRGG  GGNFGVVSTF  KLKVYRCSQK  IHAGTIAFPR  TAMKAVSQGV  SDFASRYTDP240
KIAAHVSVTN  FASPDDQNEA  TKPDVTMHIF  DSHGEEHARS  ELGFKWAFDI  EGAVDMTKEL300
KIREVNELTA  SLRFGDHNHS  VLSSPLVDSI  DPDFVLRMAQ  FHERTVEANQ  AFRAGTFVIL360
ELMGKKTLTS  AGGPAATAWP  RTKPQHALQL  VLGYHSDTDC  STALALELLE  RGPTEIAPSH420
KPNEFWPAFL  HGFHDLSQIF  GPNYERLRQI  KTKYDPKGRK  ILQARQVARF  RFPPVFHLLS480
LSITMSNLAP  SVFRQALRAY  PRRCASARPR  LSRLAAARRC  YASESNPAQA  QVSTTRAGQT540
STLPQDSIVP  GTPVSGDATV  SPSAGILKQA  TLLDQGSRPI  YLDMQATTPT  DPRVLDAMLP600
FLTGLYGNPH  SRTHAYGWET  EKATEQAREH  VAKLIGADAK  EIIFTSGATE  SNNMSIKGVA660
KFFGRSGKKK  HIITSQTEHK  CVLDSCRHLQ  DEGFEVTYLP  VQNNGLINLD  DLKAAIRPET720
ALVSIMTVNN  EIGVIQPIKE  IGAICRANKV  FLHTDAAQAV  GKIPIDVNDW  NVDLLSISGH780
KIYGPKGIGA  CYVRRRPRVR  LDPIITGGGQ  ERGLRSGTLA  PHLVVGFGEA  CRIATEEMEY840
DAKRIEYLSK  RLLDGLLSME  HTTLNGDPDK  HYPGCVNVSF  AYVEGESLLM  ALKDIALSSG900
SACTSASLEP  SYVLRALGNS  DESAHSSIRF  GIGRFTTESE  IDYVLKAVRE  RVSFLRELSP960
LWELVQEGVD  LNTIQWSQH979

Enzyme Prediction      help

EC 1.1.3.-:1

CAZyme Signature Domains help

Created with Snap48971461952442933423914404895385876366857347838328819304245AA7
Family Start End Evalue family coverage
AA7 32 270 7.9e-41 0.5262008733624454

CDD Domains      download full data without filtering help

Created with Snap4897146195244293342391440489538587636685734783832881930580942PLN02651579979PRK14012578963NifS579979IscS580961FeS_nifS
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
178257 PLN02651 0.0 580 942 1 364
cysteine desulfurase
184450 PRK14012 0.0 579 979 4 404
IscS subfamily cysteine desulfurase.
224029 NifS 0.0 578 963 1 386
Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism].
131061 IscS 0.0 579 979 4 402
cysteine desulfurase IscS. This model represents IscS, one of several cysteine desulfurases from a larger protein family designated (misleadingly, in this case) class V aminotransferases. IscS is one of at least 6 enzymes characteristic of the IscSUA-hscAB-fsx system of iron-sulfur cluster assembly. Scoring almost as well as proteobacterial sequences included in the model are mitochondrial cysteine desulfurases, apparently from an analogous system in eukaryotes. The sulfur, taken from cysteine, may be used in other systems as well, such as tRNA base modification and biosynthesis of other cofactors. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other, Protein synthesis, tRNA and rRNA base modification]
132443 FeS_nifS 9.53e-179 580 961 1 379
cysteine desulfurase NifS. Members of this protein family are NifS, one of several related families of cysteine desulfurase involved in iron-sulfur (FeS) cluster biosynthesis. NifS is part of the NIF system, usually associated with other nif genes involved in nitrogenase expression and nitrogen fixation. The protein family is given a fairly broad interpretation here. It includes a clade nearly always found in extended nitrogen fixation genomic regions, plus a second clade more closely related to the first than to IscS and also part of NifS-like/NifU-like systems. This model does not extend to a more distantly clade found in the epsilon proteobacteria such as Helicobacter pylori, also named NifS in the literature, built instead in TIGR03403.

CAZyme Hits      help

Created with Snap489714619524429334239144048953858763668573478383288193017202CCA72155.1|AA718229ANF89368.1|AA718229AEO58513.1|AA7|1.1.3.-43203QGA17347.1|AA743203UJO23499.1|AA7
Hit ID E-Value Query Start Query End Hit Start Hit End
CCA72155.1|AA7 1.82e-14 17 202 69 273
ANF89368.1|AA7 5.70e-13 18 229 28 252
AEO58513.1|AA7|1.1.3.- 5.70e-13 18 229 28 252
QGA17347.1|AA7 9.13e-13 43 203 48 213
UJO23499.1|AA7 2.25e-12 43 203 63 227

PDB Hits      download full data without filtering help

Created with Snap48971461952442933423914404895385876366857347838328819305639795WGB_A5789796NZU_A5789795WKP_A5639795USR_A5889795KZ5_1
Hit ID E-Value Query Start Query End Hit Start Hit End Description
5WGB_A 1.30e-203 563 979 11 426
Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and E. coli ACP1 protein at 2.75A [Homo sapiens]
6NZU_A 6.39e-203 578 979 3 403
Structure of the human frataxin-bound iron-sulfur cluster assembly complex [Homo sapiens],6NZU_E Structure of the human frataxin-bound iron-sulfur cluster assembly complex [Homo sapiens]
5WKP_A 7.12e-203 578 979 6 406
Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and Iron-Sulfur Cluster Scaffold Protein ISCU1, and E. coli ACP1 protein at 3.15A [Homo sapiens],5WKP_E Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and Iron-Sulfur Cluster Scaffold Protein ISCU1, and E. coli ACP1 protein at 3.15A [Homo sapiens],5WLW_A Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A. [Homo sapiens],5WLW_E Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A. [Homo sapiens],6UXE_A Structure of the human mitochondrial desulfurase complex Nfs1-ISCU2(M140I)-ISD11 with E.coli ACP1 at 1.57 A resolution showing flexibility of N terminal end of ISCU2 [Homo sapiens],6W1D_A Structure of human mitochondrial complex Nfs1-ISCU2 (WT)-ISD11 with E.coli ACP1 at 1.8 A resolution (NIAU)2 [Homo sapiens],6WI2_A Structure of human mitochondrial complex Nfs1-ISCU2-ISD11 with E.coli ACP1 at 1.95 A resolution (NIAU)2. N-terminal mutation of ISCU2 (L35) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. [Homo sapiens],6WIH_A N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. Structure of human mitochondrial complex Nfs1-ISCU2(L35H36)-ISD11 with E.coli ACP1 at 1.9 A resolution (NIAU)2. [Homo sapiens],7RTK_A Chain A, Cysteine desulfurase, mitochondrial [Homo sapiens]
5USR_A 1.04e-202 563 979 11 426
Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms [Homo sapiens],5USR_C Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms [Homo sapiens],5USR_E Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms [Homo sapiens],5USR_G Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms [Homo sapiens]
5KZ5_1 2.42e-196 588 979 1 391
Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_2 Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_3 Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_4 Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_M Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_N Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_O Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_P Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_Q Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_R Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_S Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_T Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens]

Swiss-Prot Hits      download full data without filtering help

Created with Snap4897146195244293342391440489538587636685734783832881930485979sp|P0DN31|NFS1_ARTBC576979sp|P87185|NFS1_CANAL576979sp|P87187|NFS1_CANMA576979sp|P25374|NFS1_YEAST556979sp|O60028|NFS1_ASHGO
Hit ID E-Value Query Start Query End Hit Start Hit End Description
sp|P0DN31|NFS1_ARTBC 8.06e-284 485 979 1 503
Cysteine desulfurase, mitochondrial OS=Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) OX=663331 GN=ARB_05732-2 PE=3 SV=1
sp|P87185|NFS1_CANAL 3.14e-216 576 979 85 488
Cysteine desulfurase, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=NFS1 PE=2 SV=1
sp|P87187|NFS1_CANMA 6.98e-214 576 979 81 484
Cysteine desulfurase, mitochondrial OS=Candida maltosa OX=5479 GN=SPL1 PE=3 SV=1
sp|P25374|NFS1_YEAST 9.11e-210 576 979 96 497
Cysteine desulfurase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=NFS1 PE=1 SV=2
sp|O60028|NFS1_ASHGO 2.27e-208 556 979 67 490
Cysteine desulfurase, mitochondrial OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) OX=284811 GN=NFS1 PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI CS Position
1.000063 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in PABG_05803-t30_1-p1.