CAZyme Information: PAAG_04602-t30_1-p1

Basic Information

• Species: Paracoccidioides lutzii
• Lineage: Ascomycota; Eurotiomycetes; ; NA; Paracoccidioides; Paracoccidioides lutzii
• CAZyme ID: PAAG_04602-t30_1-p1
• CAZy Family: GH43
• CAZyme Description: mannosyl-oligosaccharide glucosidase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
822	KN294002|CGC1	93176.35	4.7182

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_PlutziiPb01	8953	502779	127	8826

• Gene Location: location=KN294002:824993-827890(-)

Full Sequence      

MFFALRFLLCCLLSSASLAARQDPLTAPDNVLILAKEVGRASNESLLWGPYRPNLYFGVR
PRIPQSLLMGLIWAKLDDFDTVQQSGHTCEQNEGMAGYGWDEYDIRKGGRQTIHDAGNTI
DLTIDFIKVPGGNNGGNWGARVKGTLRPDAPPNQVTTVIFYAAMEGLGSLQVANEVDPLG
YEGDVKFKGSAMGLGDFTIDITCGPESNAHPPRSNAAYDEKPLDRTMIAGLQIPSDALWE
AKAILFAHMKEQIDATMNKYGTEEPPPPAQIFTIANKVDDGNIYFVQKVFEGPFEFDILF
SSDSSPEAITSTKLTKEIKSASASFSEKFHEVFSPLAPFNAPKYTEFSKAMFSNLVGGIG
YFYGNSLVDRSNAPEYEEEDEGFWEEAAEARMRADPILAGPSELFTSIPSRPFFPRGFLW
DEGFHLIPIIDWDLDLTLEITKSWFNLMDEDGWIAREQILGTEAHSKVPAEFQVQHPYYA
NPPTLFMILEIFVDKLQLNKSIGHEQIEMHGLLSDIRSIHLENPDLAISYLRSIYPLLKR
HYFWFKKTQWGDIKSYDREAFSSKEAYRWRGRSVKHILASGLDDYPRPQPPHPGELHVDL
ISWMGMMTRAIRRIAEALGEIEDVEEFTVYETAITRNIDDLHWDKAAQTYCDATIDDYEE
HVHVCHKGYVSIFPFMTGLIPADSPRLGPVLDLIQNPEELWSDYGIRSLSKKDKFYGTEE
NYWRSPIWININYLILKNLLDVAGVAGPHQDQAREMYTQLRKNIVENVFDQWKKTGFAWE
QYNPETGAGQRTQHFTGWTSLVVKMMIMPDLNAEQKSGHEEL

Enzyme Prediction     

EC	3.2.1.106:25	3.2.1.-:4

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH63	595	806	1.5e-35	0.43157894736842106

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
397353	Glyco_hydro_63	0.0	309	808	1	494	Glycosyl hydrolase family 63 C-terminal domain. This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the C-terminal catalytic domain.
407154	Glyco_hydro_63N	1.75e-111	46	267	1	221	Glycosyl hydrolase family 63 N-terminal domain. This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the N-terminal beta sandwich domain.
225942	GDB1	1.27e-05	454	756	304	561	Glycogen debranching enzyme (alpha-1,6-glucosidase) [Carbohydrate transport and metabolism].
215307	PLN02567	0.001	598	803	328	537	alpha,alpha-trehalase

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QSS68976.1|GH63	0.0	12	822	11	818
QSS50985.1|GH63	0.0	12	822	11	818
QSS63216.1|GH63	0.0	12	822	11	818
CAL00956.1|GH63	0.0	13	822	14	822
BCS02288.1|GH63	0.0	13	822	14	822

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4J5T_A	1.53e-182	36	806	5	800	Crystal structure of Processing alpha-Glucosidase I [Saccharomyces cerevisiae S288C]
5MHF_A	4.82e-136	46	806	37	775	Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus],5MHF_B Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus],5MHF_C Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus],5MHF_D Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|O14255|GCS1_SCHPO	2.72e-242	36	806	32	804	Probable mannosyl-oligosaccharide glucosidase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC6G10.09 PE=3 SV=1
sp|P53008|CWH41_YEAST	1.53e-181	36	806	35	830	Mannosyl-oligosaccharide glucosidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CWH41 PE=1 SV=1
sp|Q80UM7|MOGS_MOUSE	2.35e-136	46	806	92	830	Mannosyl-oligosaccharide glucosidase OS=Mus musculus OX=10090 GN=Mogs PE=1 SV=1
sp|O88941|MOGS_RAT	4.39e-132	48	806	94	830	Mannosyl-oligosaccharide glucosidase OS=Rattus norvegicus OX=10116 GN=Mogs PE=1 SV=1
sp|Q13724|MOGS_HUMAN	6.19e-128	46	806	94	833	Mannosyl-oligosaccharide glucosidase OS=Homo sapiens OX=9606 GN=MOGS PE=1 SV=5

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000224	0.999788	CS pos: 19-20. Pr: 0.9808

TMHMM  Annotations     

There is no transmembrane helices in PAAG_04602-t30_1-p1.