dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: PAAG_02677-t30_1-p1

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Basic Information help

Species

Paracoccidioides lutzii

Lineage

Ascomycota; Eurotiomycetes; ; NA; Paracoccidioides; Paracoccidioides lutzii

CAZyme ID

PAAG_02677-t30_1-p1

CAZy Family

GH132

CAZyme Description

hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
2492		282483.41	7.8035

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_PlutziiPb01	8953	502779	127	8826

Gene Location

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in PAAG_02677-t30_1-p1.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GT76	27	440	6.6e-93	0.8968058968058968

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
406818	BLM10_mid	0.0	903	1430	1	499	Proteasome-substrate-size regulator, mid region. The ordered regions of the yeast BLM10 or PA200 (human homolog), full-length protein encode 32 HEAT repeat (HR)-like modules, each comprising two helices joined by a turn, with adjacent repeats connected by a linker. Whereas a standard HEAT repeat is composed of ~50 residues, the BLM10 HEAT repeats are highly variable. The length of helices ranges from 8 to 35 residues, turns range from 2 to 87 residues, and linkers range from 1 to 88 residues, with the longest linker, between HR21 and HR22, containing additional secondary structures (two strands and three helices). BLM10_mid is the middle ordered region of the three in BLM10. BLM10 is found to surround the proteasome entry pore in the 1.2 MDa complex of proteasome and BLM10 to form a largely closed dome that is expected to restrict access of potential substrates. Thus Blm10 and PA200 are predominantly nuclear and stimulate the degradation of model peptides, although they do not appear to stimulate the degradation of proteins, recognize ubiquitin, or utilize ATP.
403208	DUF3437	2.39e-38	2404	2491	1	86	Domain of unknown function (DUF3437). This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 142 to 163 amino acids in length.
282094	Mannosyl_trans2	4.00e-37	80	440	53	392	Mannosyltransferase (PIG-V). This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.
406851	BLM10_N	1.64e-26	540	615	1	81	Proteasome-substrate-size regulator, N-terminal. The ordered regions of the yeast BLM10 or PA200 (human homolog), full-length protein encode 32 HEAT repeat (HR)-like modules, each comprising two helices joined by a turn, with adjacent repeats connected by a linker. Whereas a standard HEAT repeat is composed of ~50 residues, the BLM10 HEAT repeats are highly variable. The length of helices ranges from 8 to 35 residues, turns range from 2 to 87 residues, and linkers range from 1 to 88 residues, with the longest linker, between HR21 and HR22, containing additional secondary structures (two strands and three helices). BLM10_N is the N-terminal ordered region of the three in BLM10. BLM10 is found to surround the proteasome entry pore in the 1.2 MDa complex of proteasome and BLM10 to form a largely closed dome that is expected to restrict access of potential substrates. BLM10 and PA200 are predominantly nuclear and stimulate the degradation of model peptides, although they do not appear to stimulate the degradation of proteins, recognize ubiquitin, or utilize ATP.
227829	COG5542	5.15e-15	79	438	69	362	Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism].

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start
2.65e-195	6	451	9	447
4.05e-174	64	451	48	431
1.14e-114	17	439	20	407
8.64e-114	19	439	19	419
6.67e-113	18	439	16	406

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
7.08e-99	578	2486	69	1871	cryo-EM structure of human PA200 [Homo sapiens],6KWY_c human PA200-20S complex [Homo sapiens]
1.09e-98	578	2486	34	1836	Human 20S-PA200 Proteasome Complex [Homo sapiens],6REY_d Human 20S-PA200 Proteasome Complex [Homo sapiens]
1.52e-62	1485	2492	8	997	Chain A6, Proteasome activator BLM10 [Saccharomyces cerevisiae],4V7O_A8 Chain A8, Proteasome activator BLM10 [Saccharomyces cerevisiae],4V7O_B5 Chain B5, Proteasome activator BLM10 [Saccharomyces cerevisiae],4V7O_B8 Chain B8, Proteasome activator BLM10 [Saccharomyces cerevisiae]
3.46e-34	618	1430	4	792	Chain A5, Proteasome activator BLM10 [Saccharomyces cerevisiae],4V7O_A7 Chain A7, Proteasome activator BLM10 [Saccharomyces cerevisiae],4V7O_B4 Chain B4, Proteasome activator BLM10 [Saccharomyces cerevisiae],4V7O_B7 Chain B7, Proteasome activator BLM10 [Saccharomyces cerevisiae]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
5.07e-108	18	439	16	388	GPI mannosyltransferase 2 OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=gpi18 PE=3 SV=1
2.96e-107	19	454	28	410	GPI mannosyltransferase 2 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=gpi18 PE=3 SV=1
6.12e-99	578	2486	34	1836	Proteasome activator complex subunit 4 OS=Mus musculus OX=10090 GN=Psme4 PE=1 SV=1
5.60e-98	578	2486	34	1836	Proteasome activator complex subunit 4 OS=Homo sapiens OX=9606 GN=PSME4 PE=1 SV=2
2.09e-97	578	2486	19	1818	Proteasome activator complex subunit 4B OS=Danio rerio OX=7955 GN=psme4b PE=3 SV=2

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
1.000018	0.000007

TMHMM Annotations download full data without filtering help

Start	End
20	42
108	130
145	167
180	202
254	273
285	307
350	372
402	424