CAZyme Information: OTA37455.1

Basic Information

• Species: Hortaea werneckii
• Lineage: Ascomycota; Dothideomycetes; ; Teratosphaeriaceae; Hortaea; Hortaea werneckii
• CAZyme ID: OTA37455.1
• CAZy Family: GT2
• CAZyme Description: Chitin synthase A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1060		118009.49	6.6200

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_HwerneckiiEXF-2000	15649	1157616	29	15620

• Gene Location: location=MUNK01000020:77103-80435(-)

Full Sequence      

MASNNPWGYGPPPGYSGEDEGTPSGPQSHNGSTMRLLTSSDEPEFAQPTPTRSPYNPFAR
SEDYQLPNPVQADDSDLSSLLRDVESDLSSNPRPSAPRTKTAKVRFKNKDKDSNVSSAPS
EHQSQNPFERTYDPTEPNTSRSRQTSVLDNAPQMPPPTDMPAYMPYRPSSRGSSSPTRPL
SPLRNSTDYARPPASSNPYEPADINGAPRPGTPSTQYGGSPRRPLPPQPLFAAGRPPSFD
IGRGEEADMTSIPIDGDEDPFGPPTRDSEDTLNGEEDEHGQRPGLKQHDSFVSQSTFTDS
LYDEKDEELYGPAPSGKQARRGVREAQMSKKEVQLINGELILECKIPTILYSFLPRRDDV
EFTHMRYTAVTCDPDDFVDKGYKLRQNIGSTSRETELLICITMYNENEVDFTRTMHGVMR
NIAHFCSRAKSRTWGKDGWQKIVVCIISDGRGKVHPRTLDAIAAMGCYQSGIAKNQVNQR
DVTAHVYEYTTQVSLDSDLKFKGAEKGIVPCQMIFCLKEKNLKKLNSHRWLFNAIGQALN
PNVCILLDVGTRPGDDSLYHLWKAFDRDSTVAGAAGEIKAAKGKAWSALLNPLVASQNFE
YKMSNILDKPLESVFGYISVLPGALSAYRFHALQNDETGHGPLSQYFKGETLHGQDADVF
TANMYLAEDPVYGLLHFKQVWMTDHTLARKFLLHIEFVYQFIQLLFTFFSLGNFYLTFYF
VAGSLADEKMDPFGHHVGRGIFIFLRYCCVLCIMMQFVLSMGNRPQGAKKMFLWSMVTFS
VIMAYTTFASIYIVVIQFTGGSGVKLSDSLFTNMVVSILSTIGLYFIMSFLYLDPWHMFT
SSAQYFMLLPSYLCTLQVYAFCNAHDVSWGTKGDNIAKDLGVAKVNKNGTVEVDMPSEQL
DIDSGYDEALRNLRDRIEVPSGGISESQAQEDYYRAVRTYVVIVWLTCNAILAMAVSEVY
GTTYIGDNIYLKFILWSVAILALFRAIGSGTFLAINVINAFMEGKLKMQTKRDNKPKGPK
LGGGWRSKLSTPSWVSSTGSWMSSKASSWTPSSIGSSIGR

Enzyme Prediction     

EC	2.4.1.16:26

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT2	403	565	3.3e-78	0.9938650306748467

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
396286	Chitin_synth_1	1.69e-114	403	565	1	163	Chitin synthase. This region is found commonly in chitin synthases classes I, II and III. Chitin a linear homopolymer of GlcNAc residues, it is an important component of the cell wall of fungi and is synthesized on the cytoplasmic surface of the cell membrane by membrane bound chitin synthases.
133033	Chitin_synth_C	1.63e-66	399	681	1	207	C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin. Chitin synthase, also called UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyltransferase, catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of GlcNAc residues formed by covalent beta-1,4 linkages. Chitin is an important component of the cell wall of fungi and bacteria and it is synthesized on the cytoplasmic surface of the cell membrane by membrane bound chitin synthases. Studies with fungi have revealed that most of them contain more than one chitin synthase gene. At least five subclasses of chitin synthases have been identified.
400626	Chitin_synth_1N	8.77e-34	332	402	1	70	Chitin synthase N-terminal. This is the N-terminal domain of Chitin synthase (pfam01644).
224136	BcsA	4.70e-17	514	872	115	422	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility].
133045	CESA_like	2.82e-15	504	633	46	166	CESA_like is the cellulose synthase superfamily. The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
UJO15676.1|GT2	0.0	1	1060	1	1131
USW54165.1|GT2	0.0	2	1060	3	1169
SMR52932.1|GT2	0.0	127	1058	43	1025
SMQ51014.1|GT2	0.0	127	1058	43	1025
SMR54387.1|GT2	0.0	140	1058	61	1025

PDB Hits     

OTA37455.1 has no PDB hit.

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|P30589|CHS2_NEUCR	0.0	144	1009	119	1062	Chitin synthase 2 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) OX=367110 GN=chs-2 PE=3 SV=4
sp|P30600|CHS1_EXODE	0.0	169	1012	49	937	Chitin synthase 1 OS=Exophiala dermatitidis OX=5970 GN=CHS1 PE=3 SV=2
sp|P30584|CHSA_EMENI	0.0	132	1009	31	959	Chitin synthase A OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=chsA PE=3 SV=2
sp|Q92444|CHS2_PARBR	0.0	173	1007	80	974	Chitin synthase 2 OS=Paracoccidioides brasiliensis OX=121759 GN=CHS2 PE=3 SV=2
sp|P87073|CHS1_PHYB8	2.41e-251	310	997	89	838	Chitin synthase 1 OS=Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555) OX=763407 GN=chs1 PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
1.000071	0.000000

TMHMM  Annotations     

Start	End
699	721
742	759
774	796
809	831
841	863
942	964
979	1001