CAZyme Information: OTA36665.1

Basic Information

• Species: Hortaea werneckii
• Lineage: Ascomycota; Dothideomycetes; ; Teratosphaeriaceae; Hortaea; Hortaea werneckii
• CAZyme ID: OTA36665.1
• CAZy Family: GH92
• CAZyme Description: Beta-mannosidase [Source:UniProtKB/TrEMBL;Acc:A0A1Z5TL19]

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
929	MUNK01000029|CGC3	104703.72	4.4042

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_HwerneckiiEXF-2000	15649	1157616	29	15620

• Gene Location: location=MUNK01000029:187906-191443(+)

Full Sequence      

MLHRTLAAAAAVIVPFAFPQKIISLVGDAWTVSNPELNVSVPAHLPSQAHLDLYANQVIG
DPYYGLNDFNLRWVAWSNWTYTSAPIVGLSSNASSTWLQFDGLDTFTSIEFCGQHVASTN
NQFRQYWFDVSSILSSCPAEEDRVLSINFGSAPKIANAIANEPGQETWPDGVQIQFEFLN
RWFIRKEQSDFGWDWGPAFAPAGPWKPAYVVQLEKEQMQVRNTLVDIYRQGQLPLTIPDQ
SQPWIINASMDYYGDLPRDAELRYTLIDMKNNTIYRGELTDVNSTESIITGQTMIPNGAV
DLWWPNGMGEQNLYYIAIEVMSPSNRSIASVSKRVGFRTIVLNEYPISDAQLAQGIAAGN
NWHFEINGHEFYAKGSNFIPPDAFWPRVTPERIDTLFDSVVEGNQNMLRVWSSGAYSPDY
MYDSADVRGILLWSEFEFGDALYPVNPEFLANIADEARYQVRRVNHHPSLALWAGGNELE
NLELDLVNESAPKEYPKYLKQYETVFLDTLLPAVFENTRSISYTPSSTSNGWQSLNFSNP
IPIVERYNNLTPGYIYGETDFYNYDPSVLYNDSAYPVGRFSNEFGYHSMPSIQSWRSQIS
EADLDFNSSTVMLRDHHPPAEGLNTSNFANASIGQAQMTEAVELWYPTPNKTDSVANFSA
WCHATQIFQADLYVSEIRFYRRGSGLPERQLGSLYWQLEDIWVAPSWAGIEYDGRWKILH
YAAKDAYQPIVISPYYDMATGNLSAWVTSDLWDPASGTAKFQWFNWEGNRLPINTSSSVD
FNIGAINSTKVLQTFTGVILGDYNPENVVLRMQVGAEGKLPNTNSTRTFLHESWFHPTAL
RSANLVDPGLTLEYSESTKNFTVTAKTGVAAWVWLDYPAGAVVAFDSNGFWLGADCSREI
GYKVKSDSTDGKWLEGVTVQSLYNQTLPY

Enzyme Prediction     

EC	3.2.1.25:4

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH2	42	763	2.2e-67	0.6183510638297872

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
225789	LacZ	6.19e-40	18	729	8	631	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].
407625	Ig_mannosidase	2.28e-15	847	924	1	78	Ig-fold domain. This Ig-like fold domain is found in mannosidase enzymes.
407658	Mannosidase_ig	6.12e-09	741	820	1	78	Mannosidase Ig/CBM-like domain. This domain corresponds to domain 4 in the structure of Bacteroides thetaiotaomicron beta-mannosidase, BtMan2A. This domain has an Ig-like fold.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
UJO11998.1|GH2	0.0	15	927	17	930
SMY20222.1|GH2	0.0	21	928	22	931
SMQ46536.1|GH2	0.0	21	928	19	928
SMR45057.1|GH2	0.0	24	928	22	928
SMR42887.1|GH2	0.0	24	927	22	927

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4CVU_A	0.0	30	928	38	942	Structure of Fungal beta-mannosidase from Glycoside Hydrolase Family 2 of Trichoderma harzianum [Trichoderma harzianum],4UOJ_A Chain A, BETA-MANNOSIDASE GH2 [Trichoderma harzianum],4UOJ_B Chain B, BETA-MANNOSIDASE GH2 [Trichoderma harzianum]
6DDT_A	1.01e-108	21	890	9	833	mouse beta-mannosidase (MANBA) [Mus musculus],6DDU_A mouse beta-mannosidase bound to beta-D-mannose (MANBA) [Mus musculus]
2VJX_A	1.80e-76	23	753	8	675	Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VJX_B Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VL4_A Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VL4_B Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VMF_A Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VMF_B Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VO5_A Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VO5_B Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VOT_A Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VOT_B Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VQT_A Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron],2VQT_B Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron],2VR4_A Transition-state mimicry in mannoside hydrolysis: characterisation of twenty six inhibitors and insight into binding from linear free energy relationships and 3-D structure [Bacteroides thetaiotaomicron VPI-5482],2VR4_B Transition-state mimicry in mannoside hydrolysis: characterisation of twenty six inhibitors and insight into binding from linear free energy relationships and 3-D structure [Bacteroides thetaiotaomicron VPI-5482]
2JE8_A	1.86e-76	23	753	10	677	Structure of a beta-mannosidase from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482],2JE8_B Structure of a beta-mannosidase from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482]
7OP6_A	1.89e-76	23	753	10	677	Chain A, Beta-mannosidase [Bacteroides thetaiotaomicron VPI-5482],7OP6_B Chain B, Beta-mannosidase [Bacteroides thetaiotaomicron VPI-5482],7OP7_A Chain A, Beta-mannosidase [Bacteroides thetaiotaomicron VPI-5482],7OP7_B Chain B, Beta-mannosidase [Bacteroides thetaiotaomicron VPI-5482]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q9UUZ3|MANBA_ASPNG	0.0	7	925	9	927	Beta-mannosidase A OS=Aspergillus niger OX=5061 GN=mndA PE=1 SV=1
sp|Q2UN00|MANBA_ASPOR	0.0	5	927	6	912	Beta-mannosidase A OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=mndA PE=3 SV=1
sp|Q4WMS9|MANBA_ASPFU	0.0	15	925	17	922	Beta-mannosidase A OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=mndA PE=3 SV=1
sp|Q5BCI8|MANBA_EMENI	0.0	23	925	24	924	Beta-mannosidase A OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=mndA PE=3 SV=1
sp|A1DMT2|MANBA_NEOFI	0.0	15	925	17	926	Beta-mannosidase A OS=Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) OX=331117 GN=mndA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
0.642545	0.357469

TMHMM  Annotations     

There is no transmembrane helices in OTA36665.1.