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CAZyme Information: OTA34450.1
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Hortaea werneckii | |||||||||||
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| Lineage | Ascomycota; Dothideomycetes; ; Teratosphaeriaceae; Hortaea; Hortaea werneckii | |||||||||||
| CAZyme ID | OTA34450.1 | |||||||||||
| CAZy Family | GH5 | |||||||||||
| CAZyme Description | Branchpoint-bridging protein [Source:UniProtKB/TrEMBL;Acc:A0A1Z5TEP3] | |||||||||||
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CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| 227503 | MSL5 | 5.76e-101 | 64 | 310 | 20 | 269 | Splicing factor (branch point binding protein) [RNA processing and modification]. |
| 406640 | SF1-HH | 1.61e-57 | 75 | 185 | 1 | 114 | Splicing factor 1 helix-hairpin domain. This domain, approximately 100 residues in length, is mainly found in splicing factor 1 from yeast to human. It is a helix-hairpin domain, which forms a secondary, hydrophobic interface with U2AF65(UHM) to lock the orientation of the two subunits, which is essential for cooperative formation of the ternary SF1-U2AF65-RNA complex. In this domain, it contains a highly conserved SPSP motif in its C terminal and phophorylation of SPSP motif induces a disorder-to-order transition within a novel SF1/U2AF65 interface, indicating a phosphorylation-dependent control of pre-mRNA splicing factors. |
| 411805 | KH-I_BBP | 7.77e-52 | 189 | 280 | 1 | 92 | type I K homology (KH) RNA-binding domain found in yeast branchpoint-bridging protein (BBP) and similar proteins. Yeast BBP, also called mud synthetic-lethal 5 protein, or splicing factor 1, or zinc finger protein BBP, is a mammalian splicing factor SF1 ortholog. It is involved in protein-protein interactions that bridge the 3' and 5' splice-site ends of the intron during the early steps of yeast pre-mRNA splicing. BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC. |
| 411810 | KH-I_SF1 | 8.46e-33 | 189 | 279 | 1 | 92 | type I K homology (KH) RNA-binding domain found in splicing factor 1 (SF1) and similar proteins. SF1, also called branch point-binding protein, or BBP, or transcription factor ZFM1, or zinc finger gene in MEN1 locus, or zinc finger protein 162, is necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. It may act as transcription repressor. |
| 411811 | KH-I_Hqk_like | 1.18e-25 | 189 | 275 | 1 | 95 | type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) family. The Hqk family includes Hqk and protein held out wings (how) found in Drosophila. Hqk, also called HqkI, is an RNA-binding protein that plays a central role in myelinization. It binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence and regulates target mRNA stability. It acts by regulating pre-mRNA splicing, mRNA export and protein translation. Hqk is a regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. How, also called KH domain protein KH93F, or protein muscle-specific, or protein Struthio, or protein wings held out (who), or Quaking-related 93F (qkr93F), is an RNA-binding protein involved in the control of muscular and cardiac activity. It is required for integrin-mediated cell-adhesion in wing blade. It plays essential roles during embryogenesis, in late stages of somatic muscle development, for myotube migration and during metamorphosis for muscle reorganization. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| 4.80e-288 | 575 | 1110 | 422 | 959 | |
| 5.38e-282 | 529 | 1110 | 378 | 961 | |
| 6.08e-281 | 529 | 1110 | 378 | 961 | |
| 6.08e-281 | 529 | 1110 | 378 | 961 | |
| 6.28e-281 | 529 | 1110 | 379 | 962 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 1.17e-43 | 186 | 310 | 2 | 127 | Crystal structure of Msl5 protein in complex with RNA at 1.8 A [Saccharomyces cerevisiae S288C],4WAN_C Crystal structure of Msl5 protein in complex with RNA at 1.8 A [Saccharomyces cerevisiae S288C],4WAN_E Crystal structure of Msl5 protein in complex with RNA at 1.8 A [Saccharomyces cerevisiae S288C],4WAN_G Crystal structure of Msl5 protein in complex with RNA at 1.8 A [Saccharomyces cerevisiae S288C] |
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| 2.60e-42 | 186 | 310 | 2 | 127 | Crystal structure of selenomethionine Msl5 protein in complex with RNA at 2.2 A [Saccharomyces cerevisiae S288C] |
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| 3.47e-39 | 188 | 313 | 5 | 131 | Chain A, SF1-Bo isoform [Homo sapiens] |
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| 8.02e-28 | 68 | 197 | 11 | 143 | Structure, phosphorylation and U2AF65 binding of the Nterminal Domain of splicing factor 1 during 3 splice site Recognition [Homo sapiens] |
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| 3.31e-26 | 67 | 187 | 2 | 124 | Structure of phosphorylated SF1 complex with U2AF65-UHM domain [Homo sapiens],4FXW_D Structure of phosphorylated SF1 complex with U2AF65-UHM domain [Homo sapiens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 7.88e-190 | 1 | 435 | 1 | 431 | Branchpoint-bridging protein OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=bbp PE=3 SV=1 |
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| 1.60e-189 | 1 | 433 | 1 | 447 | Branchpoint-bridging protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) OX=367110 GN=bbp-1 PE=3 SV=1 |
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| 5.17e-121 | 5 | 431 | 5 | 427 | Branchpoint-bridging protein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=bpb1 PE=1 SV=1 |
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| 1.24e-104 | 51 | 420 | 109 | 467 | Branchpoint-bridging protein OS=Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) OX=283643 GN=BBP PE=3 SV=1 |
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| 1.24e-104 | 51 | 420 | 109 | 467 | Branchpoint-bridging protein OS=Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) OX=214684 GN=BBP PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | CS Position |
|---|---|---|
| 1.000063 | 0.000000 |