CAZyme Information: OAG14915.1

Basic Information

• Species: Alternaria alternata
• Lineage: Ascomycota; Dothideomycetes; ; Pleosporaceae; Alternaria; Alternaria alternata
• CAZyme ID: OAG14915.1
• CAZy Family: AA7
• CAZyme Description: unspecified product

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1502		168260.36	4.9945

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_AalternataSRC1lrK2f	13577	N/A	111	13466

• Gene Location: location=KV441497:343746-348454(-)

Full Sequence      

MMRASASILSAKALLVLSAFRHSGAHAGPSVNVALRASFNPAPYLVELLETAAEENATAY
YPILDRISEGYFDEKDTQQELYTAFRDLLQSDGHITDPAALASFEFALSIQSAAPRIEAH
YQFYKTSVEPSLEATQTKACDIWTSFHGKQYCDVHLEESFGGIESERTYQLPFDRILGNS
SALPAILYADITAPRFKKWHKTLSKTAKEGKTSYRVRHKPSSNAPTTPLIVNGYGVELQL
KRTDYIVIDDRQAEQGQKSDAQKPIGTGLDDDEDVADLKPLSKDEVSELALKAADFVAQS
EQPMDTLMKLVQDFPKYSSVIAAHNASDEFVEEHLANRNQLLPAGYNVIWINGVQIPARD
VNPYSLLAHLRRERKLINGIRSQGLSGSEVVSLLSHASIAESQTEDEPQRYDFRDTTEGG
NIILWLNDIENDPMYEGWPSELRALLQRTYPGQLPSCRRDIHNAIVSVDFTSTEDVSLAL
DTIMSLIRRGIPLRWGLVPQTATSEAIDQTKLVYHLQDAYGLPAVIEYLQVSAAKPDKAV
FDTTVKRTTLIEGKEALAFDDVLKSEALDQRISGAKQYLKRLAAEGPKAPIFVNGVPIPA
TDEWLQTLSQRIGMDLRQIQKGVFNGVFNDDSWVPQYFLFQAAAKRNPLIIPENEKNITL
INMAEFEEVHGEAYSKMPRLDASESASKSDWIHITLVADFDSEAGFALLKALADFHEANP
NVEAVLIHNDKAGAEQSNASEDLLATYIKSGRKLTSEALSGLLGKEVNYGPTPANSTLFW
KVAEPIYDAVGLKPGQNGLLVNGRYVGPIPEDYTFSQDDMETFVTYEITKRIEPLNKALA
DLQLMDKIASPLDVAKIQSLVALSTVSDVPEGIFETASTLRMSTYNDWKSKYTAIVRGDE
DKAVFQIVASIDPATEQAQKWVPILKVLSDMDGVHLKLFLNPKGMLQELPVKRFYRYVLE
ARPQFTHDGSVGRLGAHFGGIPKEALLNLGMDVPPSWLVAPEESIHDLDNIKLSTTPAGT
NIDAIYGLESILIEGHSRDTTNGGQPPRGAEVVLATERDPHFADTIIMANLGYFQFKANP
GFYNIKLKSGRSQEVFNLDSAGPISWAPQPGDETTEIALMSFQGATIFPRLSRKPGQEDT
DVLAPEESLASELVGKSAQKVNKFLGKMGLNFDSEKVLQKGADLFSGGKTAKKGTQADIN
IFSVASGHLYERMLNIMMVSVMKHTKHTVKFWFIEQFLSPSFKSFLPHIAAEYGFEYEMV
TYKWPHWLRGQTEKQREIWGYKILFLDVLFPLDLEKVIFVDADQIVRTDMFELVQHDLEG
APYGFTPMGDSRTEMEGFRFWKTGYWANFLRGRPYHISALYVVDLNRFRQLAAGDRLRQQ
YHSLSADPNSLSNLDQDLPNNMQFNLPIHSLPQEWLWCETWCSDEDLAKAKTIDLCNNPQ
TKEPKLDRARRQVPEWNVYDEEIAALARRVKGEKRKEVVDVQEEEQRREKKEKDAEIEHS
EL

Enzyme Prediction     

EC	2.4.1.-:29

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT24	1199	1446	1.3e-133	0.9959677419354839

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
133054	GT8_HUGT1_C_like	0.0	1199	1446	1	248	The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family. C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
408203	Glyco_transf_24	0.0	1199	1466	1	268	Glucosyltransferase 24. This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
408201	Thioredoxin_14	2.98e-96	411	650	1	248	Thioredoxin-like domain. This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
408202	Thioredoxin_15	4.42e-65	662	862	1	204	Thioredoxin-like domain. This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
399437	UDP-g_GGTase	1.33e-59	1034	1144	1	109	UDP-glucose:Glycoprotein Glucosyltransferase. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
CAE6999215.1|GT24	0.0	2	1502	1	1508
CBX94261.1|GT24	0.0	2	1488	1	1494
QRC95338.1|GT24	0.0	6	1502	5	1505
AQQ13387.1|GT24	0.0	26	1473	23	1482
AOZ60530.1|GT24	0.0	27	1473	24	1482

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5MU1_A	0.0	27	1476	7	1457	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5MZO_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TRF_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
5NV4_A	0.0	27	1476	7	1457	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
5Y7O_A	0.0	30	1143	5	1123	Crystal structure of folding sensor region of UGGT from Thermomyces dupontii [Thermomyces dupontii],5Y7O_B Crystal structure of folding sensor region of UGGT from Thermomyces dupontii [Thermomyces dupontii]
6TS2_A	0.0	27	1476	7	1223	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_C Chain C, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_D Chain D, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
6TS8_A	0.0	29	1408	2	1382	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS8_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q09140|UGGG_SCHPO	1.01e-265	26	1477	17	1435	UDP-glucose:glycoprotein glucosyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gpt1 PE=1 SV=2
sp|Q09332|UGGG_DROME	6.84e-237	31	1470	30	1511	UDP-glucose:glycoprotein glucosyltransferase OS=Drosophila melanogaster OX=7227 GN=Uggt PE=1 SV=2
sp|Q6P5E4|UGGG1_MOUSE	4.21e-235	30	1466	46	1523	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Mus musculus OX=10090 GN=Uggt1 PE=1 SV=4
sp|Q9NYU2|UGGG1_HUMAN	9.65e-234	30	1474	46	1531	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3
sp|Q9JLA3|UGGG1_RAT	3.36e-233	8	1466	27	1523	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Uggt1 PE=1 SV=2

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000535	0.999419	CS pos: 27-28. Pr: 0.9007

TMHMM  Annotations     

There is no transmembrane helices in OAG14915.1.