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CAZyme Information: MRET_2494-t46_1-p1

You are here: Home > Sequence: MRET_2494-t46_1-p1

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Malassezia restricta
Lineage Basidiomycota; Malasseziomycetes; ; Malasseziaceae; Malassezia; Malassezia restricta
CAZyme ID MRET_2494-t46_1-p1
CAZy Family GT2
CAZyme Description mannosyl-oligosaccharide alpha-1,3-glucosidase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
1033 116149.06 6.4904
Genome Property
Genome Version/Assembly ID Genes Strain NCBI Taxon ID Non Protein Coding Genes Protein Coding Genes
FungiDB-61_MrestrictaKCTC27527 4544 N/A 138 4406
Gene Location

Full Sequence      Download help

Enzyme Prediction      help

EC 3.2.1.20:27 3.2.1.84:26

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH31 398 858 4.6e-136 0.9953161592505855

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
269889 GH31_GANC_GANAB_alpha 0.0 417 900 1 467
neutral alpha-glucosidase C, neutral alpha-glucosidase AB. This subgroup includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in electrophoretic mobility in starch gel, GANC and GANAB have been shown to have other differences, including those of substrate specificity. GANC and GANAB are key enzymes in glycogen metabolism that hydrolyze terminal, non-reducing 1,4-linked alpha-D-glucose residues from glycogen in the endoplasmic reticulum. The GANC/GANAB family includes the alpha-glucosidase II (ModA) from Dictyostelium discoideum as well as the alpha-glucosidase II (GLS2, or ROT2 - Reversal of TOR2 lethality protein 2) from Saccharomyces cerevisiae.
395838 Glyco_hydro_31 2.61e-176 398 858 1 442
Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.
224418 YicI 4.22e-149 251 904 139 713
Alpha-glucosidase, glycosyl hydrolase family GH31 [Carbohydrate transport and metabolism].
269890 GH31_glucosidase_II_MalA 3.22e-114 417 768 1 339
Alpha-glucosidase II-like. Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This subgroup also includes the MalA alpha-glucosidase from Sulfolobus solfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source.
269888 GH31_MGAM_SI_GAA 5.10e-91 417 765 1 367
maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase. This subgroup includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes Pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII).

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
0.0 1 1033 1 1033
0.0 1 993 1 993
0.0 10 1030 11 1010
0.0 9 1030 7 1060
0.0 17 1030 34 1069

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1.64e-243 28 1028 10 949
Chain A, Alpha glucosidase-like protein [Thermochaetoides thermophila DSM 1495],5DKY_A Chain A, Alpha glucosidase-like protein [Thermochaetoides thermophila DSM 1495],5JQP_A Chain A, Alpha glucosidase-like protein [Thermochaetoides thermophila DSM 1495]
2.59e-242 28 1028 10 949
Chain A, Alpha glucosidase-like protein [Thermochaetoides thermophila DSM 1495],5DL0_A Chain A, Alpha glucosidase-like protein [Thermochaetoides thermophila DSM 1495]
5.81e-217 10 1032 21 945
Chain A, Neutral alpha-glucosidase AB [Mus musculus],7KRY_C Chain C, Neutral alpha-glucosidase AB [Mus musculus]
4.49e-216 10 1032 21 967
Chain A, Alpha glucosidase 2 alpha neutral subunit [Mus musculus],7JTY_C Chain C, Alpha glucosidase 2 alpha neutral subunit [Mus musculus],7K9N_A Chain A, Alpha glucosidase 2 alpha neutral subunit [Mus musculus],7K9N_C Chain C, Alpha glucosidase 2 alpha neutral subunit [Mus musculus],7K9O_A Chain A, Alpha glucosidase 2 alpha neutral subunit [Mus musculus],7K9O_C Chain C, Alpha glucosidase 2 alpha neutral subunit [Mus musculus],7K9Q_A Chain A, Alpha glucosidase 2 alpha neutral subunit [Mus musculus],7K9Q_C Chain C, Alpha glucosidase 2 alpha neutral subunit [Mus musculus],7K9T_A Chain A, Alpha glucosidase 2 alpha neutral subunit [Mus musculus],7K9T_C Chain C, Alpha glucosidase 2 alpha neutral subunit [Mus musculus],7KAD_A Chain A, Isoform 2 of Neutral alpha-glucosidase AB [Mus musculus],7KAD_C Chain C, Isoform 2 of Neutral alpha-glucosidase AB [Mus musculus],7KB6_A Chain A, Isoform 2 of Neutral alpha-glucosidase AB [Mus musculus],7KB6_C Chain C, Isoform 2 of Neutral alpha-glucosidase AB [Mus musculus],7KB8_A Chain A, Isoform 2 of Neutral alpha-glucosidase AB [Mus musculus],7KB8_C Chain C, Isoform 2 of Neutral alpha-glucosidase AB [Mus musculus]
9.90e-216 23 1027 1 909
Murine endoplasmic reticulum alpha-glucosidase II with N-butyl-1-deoxynojirimycin [Mus musculus]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
2.41e-231 85 968 89 885
Glucosidase 2 subunit alpha OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gls2 PE=1 SV=1
6.66e-215 13 1027 23 941
Neutral alpha-glucosidase AB OS=Mus musculus OX=10090 GN=Ganab PE=1 SV=1
1.87e-214 13 1027 23 941
Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3
2.07e-213 13 1027 23 941
Neutral alpha-glucosidase AB OS=Macaca fascicularis OX=9541 GN=GANAB PE=2 SV=1
1.42e-210 11 1027 18 941
Neutral alpha-glucosidase AB OS=Sus scrofa OX=9823 GN=GANAB PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI CS Position
0.000201 0.999801 CS pos: 22-23. Pr: 0.9485

TMHMM  Annotations      download full data without filtering help

Start End
5 27