dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: KIX04546.1

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Basic Information help

Species

Rhinocladiella mackenziei

Lineage

Ascomycota; Eurotiomycetes; ; Herpotrichiellaceae; Rhinocladiella; Rhinocladiella mackenziei

CAZyme ID

KIX04546.1

CAZy Family

GH2

CAZyme Description

DOMON domain-containing protein [Source:UniProtKB/TrEMBL;Acc:A0A0D2IN52]

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
433	KN847478\|CGC14	46810.60	7.9417

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_RmackenzieiCBS650.93	11418	1442369	36	11382

Gene Location

Full Sequence Download help

Enzyme Prediction help

EC	1.1.99.18:3

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
AA8	41	194	1e-22	0.8846153846153846

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
187688	CDH_like_cytochrome	8.84e-51	41	190	16	168	Heme-binding cytochrome domain of fungal cellobiose dehydrogenases. Cellobiose dehydrogenase (CellobioseDH or CDH) is an extracellular fungal oxidoreductase that degrades both lignin and cellulose. Specifically, CDHs oxidize cellobiose, cellodextrins, and lactose to corresponding lactones, utilizing a variety of electron acceptors. Class-II CDHs are monomeric hemoflavoenzymes that are comprised of a b-type cytochrome domain linked to a large flavodehydrogenase domain. The cytochrome domain of CDH and related enzymes, which this model describes, folds as a beta sandwich and complexes a heme molecule. It is found at the N-terminus of this family of enzymes, and belongs to the DOMON domain superfamily, a ligand-interacting motif found in all three kingdoms of life.
406418	CDH-cyt	2.43e-34	41	194	15	174	Cytochrome domain of cellobiose dehydrogenase. CDH-cyt is the cytochrome domain, at the N-terminus, of cellobiose dehydrogenase. CDH-cyt folds as a beta sandwich with the topology of the antibody Fab V(H) domain and binds iron. The haem iron is ligated by Met83 and His181 in UniProtKB:Q01738.
176490	Cyt_b561_FRRS1_like	4.86e-21	183	375	2	191	Eukaryotic cytochrome b(561), including the FRRS1 gene product. Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.
214769	B561	1.81e-11	225	345	2	129	Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.
176491	Cyt_b561_CYB561D2_like	3.60e-11	225	372	32	183	Eukaryotic cytochrome b(561), including the CYB561D2 gene product. Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start
2.54e-58	43	383	35	378
1.19e-53	46	400	31	399
7.57e-53	44	365	46	376
2.77e-52	22	379	1	365
2.77e-52	22	379	1	365

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
2.14e-11	66	193	50	176	Chain A, CELLOBIOSE DEHYDROGENASE [Phanerodontia chrysosporium],1D7B_B Chain B, CELLOBIOSE DEHYDROGENASE [Phanerodontia chrysosporium],1D7D_A Chain A, CELLOBIOSE DEHYDROGENASE [Phanerodontia chrysosporium],1D7D_B Chain B, CELLOBIOSE DEHYDROGENASE [Phanerodontia chrysosporium]
2.30e-11	66	193	50	176	Chain A, CELLOBIOSE DEHYDROGENASE [Phanerodontia chrysosporium],1D7C_B Chain B, CELLOBIOSE DEHYDROGENASE [Phanerodontia chrysosporium]
1.81e-10	66	193	50	176	Chain A, Cellobiose dehydrogenase [Phanerodontia chrysosporium],1PL3_B Chain B, Cellobiose dehydrogenase [Phanerodontia chrysosporium]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
1.37e-09	66	193	68	194	Cellobiose dehydrogenase OS=Phanerodontia chrysosporium OX=2822231 GN=CDH-1 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000232	0.999753	CS pos: 26-27. Pr: 0.9799

TMHMM Annotations download full data without filtering help

Start	End
221	243
250	272
287	309
329	348
353	375