dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: KIV98786.1

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Basic Information help

Species

Verruconis gallopava

Lineage

Ascomycota; Dothideomycetes; ; Sympoventuriaceae; Verruconis; Verruconis gallopava

CAZyme ID

KIV98786.1

CAZy Family

AA1

CAZyme Description

Cutinase [Source:UniProtKB/TrEMBL;Acc:A0A0D1YDG7]

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
526	KN847597\|CGC2	57957.42	5.8130

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_VgallopavaCBS43764	9871	N/A	53	9818

Gene Location

Full Sequence Download help

Enzyme Prediction help

EC	3.1.1.74:3

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
CE5	356	518	5.2e-38	0.9576719576719577

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
293755	G6S_like	2.79e-145	3	321	1	290	unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS). N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
293758	sulfatase_like	5.88e-49	4	318	1	277	uncharacterized sulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
293766	G6S	6.31e-47	4	318	1	293	glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1). N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
395860	Cutinase	9.94e-47	356	510	1	158	Cutinase.
293751	SGSH	4.81e-46	5	306	1	227	N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase). N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start
2.71e-124	78	321	1	250
2.80e-124	78	321	1	250
3.30e-60	3	206	2	228
2.17e-54	338	526	114	303
1.33e-51	347	526	188	368

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
1.83e-84	4	321	28	366	Structure of BT4656 in complex with its substrate D-Glucosamine-2-N, 6-O-disulfate. [Bacteroides thetaiotaomicron VPI-5482]
1.65e-74	2	379	7	415	Chain A, Sulfatase [Akkermansia muciniphila ATCC BAA-835],7EBP_B Chain B, Sulfatase [Akkermansia muciniphila ATCC BAA-835],7EBQ_A Chain A, Sulfatase [Akkermansia muciniphila ATCC BAA-835]
4.21e-61	6	321	28	345	Chain A, Exo-L-galactose-6-sulfatase [Bacteroides uniformis],7LHA_B Chain B, Exo-L-galactose-6-sulfatase [Bacteroides uniformis],7LJ2_A Chain A, Exo-L-galactose-6-sulfatase [Bacteroides uniformis],7LJ2_B Chain B, Exo-L-galactose-6-sulfatase [Bacteroides uniformis]
4.26e-32	331	523	48	246	Structure of cutinase from Trichoderma reesei in its native form. [Trichoderma reesei QM6a],4PSD_A Structure of Trichoderma reesei cutinase native form. [Trichoderma reesei QM6a],4PSE_A Trichoderma reesei cutinase in complex with a C11Y4 phosphonate inhibitor [Trichoderma reesei QM6a],4PSE_B Trichoderma reesei cutinase in complex with a C11Y4 phosphonate inhibitor [Trichoderma reesei QM6a]
4.45e-25	344	509	16	191	Chain A, CUTINASE [Fusarium vanettenii]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
1.73e-83	4	321	52	390	N-acetylglucosamine-6-O-sulfatase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) OX=226186 GN=BT_4656 PE=1 SV=1
6.60e-40	350	518	24	194	Cutinase OS=Botryotinia fuckeliana OX=40559 GN=cutA PE=1 SV=1
1.20e-38	344	526	47	223	Cutinase 4 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=cut4 PE=2 SV=1
5.57e-32	323	525	9	200	Cutinase OS=Monilinia fructicola OX=38448 GN=CUT1 PE=2 SV=1
1.89e-31	331	523	48	246	Cutinase OS=Hypocrea jecorina (strain QM6a) OX=431241 GN=TRIREDRAFT_60489 PE=3 SV=2

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
1.000059	0.000002

TMHMM Annotations help

There is no transmembrane helices in KIV98786.1.