dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: KDQ25154.1

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Basic Information help

Species

Pleurotus ostreatus

Lineage

Basidiomycota; Agaricomycetes; ; Pleurotaceae; Pleurotus; Pleurotus ostreatus

CAZyme ID

KDQ25154.1

CAZy Family

CBM13

CAZyme Description

glycoside hydrolase family 61 protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
315	KL198010\|CGC6	32232.11	4.7451

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_PostreatusPC15	12460	1137138	164	12296

Gene Location

Full Sequence Download help

Enzyme Prediction help

EC	1.14.99.54:1

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
AA9	10	228	2.8e-64	0.9863636363636363

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
410622	LPMO_AA9	1.24e-77	22	245	1	216	lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 9 (AA9). AA9 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs) involved in the cleavage of cellulose chains with oxidation of carbons C1 and/or C4 and C6. Activities include lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54) and lytic cellulose monooxygenase (C4-dehydrogenating) (EC 1.14.99.56). The family used to be called GH61 because weak endoglucanase activity had been demonstrated in some family members.
397484	Glyco_hydro_61	4.67e-75	23	232	1	210	Glycosyl hydrolase family 61. Although weak endoglucanase activity has been demonstrated in several members of this family, they lack the clustered conserved catalytic acidic amino acids present in most glycoside hydrolases. Many members of this family lack measurable cellulase activity on their own, but enhance the activity of other cellulolytic enzymes. They are therefore unlikely to be true glycoside hydrolases. The subsrate-binding surface of this family is a flat Ig-like fold.
197593	fCBD	3.49e-10	282	315	1	34	Fungal-type cellulose-binding domain. Small four-cysteine cellulose-binding domain of fungi
395595	CBM_1	1.48e-09	283	311	1	29	Fungal cellulose binding domain.
397323	Atrophin-1	0.010	180	282	404	504	Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start
6.59e-176	1	308	1	309
1.93e-141	12	315	10	314
1.46e-130	6	315	5	320
1.75e-129	12	315	11	321
6.45e-127	21	315	29	320

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
1.60e-88	22	245	1	223	Crystal structure of HiLPMO9B [Heterobasidion irregulare TC 32-1],5NNS_B Crystal structure of HiLPMO9B [Heterobasidion irregulare TC 32-1]
5.42e-48	23	250	2	231	Crystal Structure of a Cellulose-active Polysaccharide Monooxygenase from M. thermophila (MtPMO3) [Thermothelomyces thermophilus ATCC 42464],5UFV_B Crystal Structure of a Cellulose-active Polysaccharide Monooxygenase from M. thermophila (MtPMO3) [Thermothelomyces thermophilus ATCC 42464],5UFV_C Crystal Structure of a Cellulose-active Polysaccharide Monooxygenase from M. thermophila (MtPMO3) [Thermothelomyces thermophilus ATCC 42464],5UFV_D Crystal Structure of a Cellulose-active Polysaccharide Monooxygenase from M. thermophila (MtPMO3) [Thermothelomyces thermophilus ATCC 42464],5UFV_E Crystal Structure of a Cellulose-active Polysaccharide Monooxygenase from M. thermophila (MtPMO3) [Thermothelomyces thermophilus ATCC 42464],5UFV_F Crystal Structure of a Cellulose-active Polysaccharide Monooxygenase from M. thermophila (MtPMO3) [Thermothelomyces thermophilus ATCC 42464]
4.71e-42	23	245	2	223	Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases (PMO-3) [Neurospora crassa OR74A]
4.71e-42	23	245	2	223	Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases (PMO-3) [Neurospora crassa OR74A]
1.47e-41	68	247	54	229	AFGH61B L90V/D131S/M134L/A141W VARIANT [Aspergillus fumigatus Af293],6HA5_B AFGH61B L90V/D131S/M134L/A141W VARIANT [Aspergillus fumigatus Af293]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
1.15e-127	21	315	29	320	Cellulose-growth-specific protein OS=Agaricus bisporus OX=5341 GN=cel1 PE=3 SV=1
1.19e-33	9	242	9	243	Endoglucanase-4 OS=Hypocrea jecorina OX=51453 GN=cel61a PE=1 SV=1
1.61e-32	79	245	85	247	Endoglucanase-7 OS=Hypocrea jecorina (strain QM6a) OX=431241 GN=cel61b PE=1 SV=3
1.64e-32	3	250	10	249	Polysaccharide monooxygenase Cel61a OS=Myceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) OX=573729 GN=Cel61a PE=1 SV=1
3.49e-26	58	250	50	237	Probable endo-beta-1,4-glucanase D OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=eglD PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000260	0.999699	CS pos: 21-22. Pr: 0.9710

TMHMM Annotations help

There is no transmembrane helices in KDQ25154.1.