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CAZyme Information: KAG5420689.1
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Candida metapsilosis | |||||||||||
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| Lineage | Ascomycota; Saccharomycetes; ; Debaryomycetaceae; Candida; Candida metapsilosis | |||||||||||
| CAZyme ID | KAG5420689.1 | |||||||||||
| CAZy Family | GT32 | |||||||||||
| CAZyme Description | MEX67 | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | ||||||||||||
Enzyme Prediction help
| EC | 2.4.1.198:3 |
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CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| 340827 | GT4_PIG-A-like | 0.0 | 622 | 1019 | 1 | 394 | phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder. |
| 340831 | GT4_PimA-like | 8.68e-57 | 622 | 989 | 1 | 365 | phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea. |
| 400541 | PIGA | 2.01e-54 | 660 | 749 | 1 | 90 | PIGA (GPI anchor biosynthesis). This domain is found on phosphatidylinositol n-acetylglucosaminyltransferase proteins. These proteins are involved in GPI anchor biosynthesis and are associated with disease the paroxysmal nocturnal haemoglobinuria. |
| 223515 | RfaB | 2.42e-51 | 622 | 992 | 2 | 377 | Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]. |
| 340844 | GT4_UGDG-like | 1.75e-37 | 622 | 992 | 1 | 372 | UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| 6.70e-272 | 1 | 1019 | 152 | 983 | |
| 5.74e-254 | 619 | 1019 | 1 | 401 | |
| 1.10e-251 | 619 | 1019 | 1 | 401 | |
| 7.62e-223 | 619 | 1019 | 1 | 401 | |
| 5.78e-222 | 619 | 1019 | 1 | 400 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6.17e-90 | 21 | 499 | 7 | 472 | Structure of Mex67:Mtr2 [Saccharomyces cerevisiae S288C],4WWU_B Structure of Mex67:Mtr2 [Saccharomyces cerevisiae S288C],4WWU_D Structure of Mex67:Mtr2 [Saccharomyces cerevisiae S288C],4WWU_E Structure of Mex67:Mtr2 [Saccharomyces cerevisiae S288C],4WWU_G Structure of Mex67:Mtr2 [Saccharomyces cerevisiae S288C],4WWU_H Structure of Mex67:Mtr2 [Saccharomyces cerevisiae S288C],4WWU_J Structure of Mex67:Mtr2 [Saccharomyces cerevisiae S288C],4WWU_K Structure of Mex67:Mtr2 [Saccharomyces cerevisiae S288C] |
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| 6.68e-82 | 298 | 504 | 4 | 215 | Crystal structure of the C. albicans Mtr2-Mex67 M domain complex [Candida albicans],1Q40_D Crystal structure of the C. albicans Mtr2-Mex67 M domain complex [Candida albicans] |
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| 4.40e-44 | 298 | 499 | 1 | 204 | Crystal structure of Mex67-Mtr2 [Saccharomyces cerevisiae] |
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| 6.79e-30 | 128 | 436 | 18 | 333 | Chain A, Mex67 [Thermochaetoides thermophila],4XM4_B Chain B, Mex67 [Thermochaetoides thermophila],4XM4_C Chain C, Mex67 [Thermochaetoides thermophila],4XM4_D Chain D, Mex67 [Thermochaetoides thermophila] |
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| 2.71e-20 | 128 | 285 | 19 | 177 | Chain A, mRNA export protein [Thermochaetoides thermophila DSM 1495] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4.45e-270 | 1 | 607 | 1 | 609 | mRNA export factor MEX67 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=MEX67 PE=1 SV=2 |
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| 6.70e-171 | 625 | 1019 | 1 | 391 | Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gpi3 PE=3 SV=1 |
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| 1.79e-159 | 619 | 992 | 1 | 378 | Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit OS=Saccharomyces cerevisiae (strain RM11-1a) OX=285006 GN=SPT14 PE=3 SV=1 |
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| 1.79e-159 | 619 | 992 | 1 | 378 | Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=SPT14 PE=1 SV=4 |
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| 1.79e-159 | 619 | 992 | 1 | 378 | Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit OS=Saccharomyces cerevisiae (strain AWRI1631) OX=545124 GN=SPT14 PE=3 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | CS Position |
|---|---|---|
| 1.000041 | 0.000022 |