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CAZyme Information: KAF7621510.1
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Aspergillus flavus | |||||||||||
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| Lineage | Ascomycota; Eurotiomycetes; ; Aspergillaceae; Aspergillus; Aspergillus flavus | |||||||||||
| CAZyme ID | KAF7621510.1 | |||||||||||
| CAZy Family | GH154 | |||||||||||
| CAZyme Description | Glycogen [starch] synthase [Source:UniProtKB/TrEMBL;Acc:A0A7G5J7N8] | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | ||||||||||||
Enzyme Prediction help
| EC | 2.4.1.11:48 |
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CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GT3 | 22 | 659 | 0 | 0.9984301412872841 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| 340824 | GT3_GSY2-like | 0.0 | 17 | 609 | 1 | 590 | glycogen synthase GSY2 and similar proteins. Glycogen synthase, which is most closely related to the GT3 family of glycosyltransferases, catalyzes the transfer of a glucose molecule from UDP-glucose to a terminal branch of a glycogen molecule, a rate-limit step of glycogen biosynthesis. GSY2, the member of this family in S. cerevisiae, has been shown to possess glycogen synthase activity. |
| 399009 | Glycogen_syn | 0.0 | 22 | 666 | 1 | 639 | Glycogen synthase. This family consists of the eukaryotic glycogen synthase proteins GYS1, GYS2 and GYS3. Glycogen synthase (GS) is the enzyme responsible for the synthesis of -1,4-linked glucose chains in glycogen. It is the rate limiting enzyme in the synthesis of the polysaccharide, and its activity is highly regulated through phosphorylation at multiple sites and also by allosteric effectors, mainly glucose 6-phosphate (G6P). |
| 340816 | Glycosyltransferase_GTB-type | 5.56e-06 | 425 | 528 | 130 | 222 | glycosyltransferase family 1 and related proteins with GTB topology. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. |
| 340831 | GT4_PimA-like | 1.99e-05 | 148 | 601 | 62 | 363 | phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea. |
| 340830 | GT4_sucrose_synthase | 6.31e-05 | 78 | 342 | 27 | 248 | sucrose-phosphate synthase and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| 0.0 | 1 | 714 | 1 | 714 | |
| 0.0 | 1 | 714 | 1 | 714 | |
| 0.0 | 1 | 714 | 1 | 714 | |
| 0.0 | 1 | 714 | 1 | 714 | |
| 0.0 | 1 | 714 | 1 | 722 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 8.09e-317 | 13 | 682 | 3 | 697 | yGsy2p in complex with small molecule [Saccharomyces cerevisiae S288C],6U77_B yGsy2p in complex with small molecule [Saccharomyces cerevisiae S288C],6U77_C yGsy2p in complex with small molecule [Saccharomyces cerevisiae S288C],6U77_D yGsy2p in complex with small molecule [Saccharomyces cerevisiae S288C] |
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| 1.39e-316 | 13 | 682 | 23 | 717 | Activated state yeast Glycogen Synthase in complex with UDP-xylose [Saccharomyces cerevisiae S288C],5UX7_B Activated state yeast Glycogen Synthase in complex with UDP-xylose [Saccharomyces cerevisiae S288C],5UX7_C Activated state yeast Glycogen Synthase in complex with UDP-xylose [Saccharomyces cerevisiae S288C],5UX7_D Activated state yeast Glycogen Synthase in complex with UDP-xylose [Saccharomyces cerevisiae S288C] |
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| 1.67e-316 | 13 | 682 | 23 | 717 | G6P bound activated state of yeast glycogen synthase 2 [Saccharomyces cerevisiae S288C],5SUK_B G6P bound activated state of yeast glycogen synthase 2 [Saccharomyces cerevisiae S288C],5SUK_C G6P bound activated state of yeast glycogen synthase 2 [Saccharomyces cerevisiae S288C],5SUK_D G6P bound activated state of yeast glycogen synthase 2 [Saccharomyces cerevisiae S288C] |
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| 3.97e-316 | 13 | 682 | 23 | 717 | Chain A, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW0_B Chain B, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW0_C Chain C, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW0_D Chain D, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW1_A Activated state yGsy2p in complex with UDP-galactose [Saccharomyces cerevisiae S288C],5UW1_B Activated state yGsy2p in complex with UDP-galactose [Saccharomyces cerevisiae S288C],5UW1_C Activated state yGsy2p in complex with UDP-galactose [Saccharomyces cerevisiae S288C],5UW1_D Activated state yGsy2p in complex with UDP-galactose [Saccharomyces cerevisiae S288C],5UW4_A Chain A, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW4_B Chain B, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW4_C Chain C, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5UW4_D Chain D, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5VNC_A Chain A, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5VNC_B Chain B, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5VNC_C Chain C, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C],5VNC_D Chain D, Glycogen [starch] synthase isoform 2 [Saccharomyces cerevisiae S288C] |
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| 4.59e-316 | 13 | 682 | 22 | 716 | Crystal structure of yeast glycogen synthase E169Q mutant in complex with glucose and UDP [Saccharomyces cerevisiae FostersO],4KQM_B Crystal structure of yeast glycogen synthase E169Q mutant in complex with glucose and UDP [Saccharomyces cerevisiae FostersO],4KQM_C Crystal structure of yeast glycogen synthase E169Q mutant in complex with glucose and UDP [Saccharomyces cerevisiae FostersO],4KQM_D Crystal structure of yeast glycogen synthase E169Q mutant in complex with glucose and UDP [Saccharomyces cerevisiae FostersO] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 0.0 | 13 | 684 | 3 | 698 | Glycogen [starch] synthase isoform 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=GSY1 PE=1 SV=3 |
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| 0.0 | 13 | 708 | 9 | 697 | Glycogen [starch] synthase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) OX=367110 GN=gsy-1 PE=2 SV=2 |
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| 2.94e-316 | 13 | 682 | 3 | 697 | Glycogen [starch] synthase isoform 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=GSY2 PE=1 SV=3 |
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| 5.53e-275 | 14 | 668 | 23 | 671 | Glycogen [starch] synthase, muscle OS=Oryctolagus cuniculus OX=9986 GN=GYS1 PE=1 SV=4 |
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| 1.42e-273 | 14 | 668 | 23 | 671 | Glycogen [starch] synthase, muscle OS=Rattus norvegicus OX=10116 GN=Gys1 PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | CS Position |
|---|---|---|
| 1.000054 | 0.000000 |