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CAZyme Information: KAF5659801.1

You are here: Home > Sequence: KAF5659801.1

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Fusarium circinatum
Lineage Ascomycota; Sordariomycetes; ; Nectriaceae; Fusarium; Fusarium circinatum
CAZyme ID KAF5659801.1
CAZy Family AA5
CAZyme Description death-associated kinase 1
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
2258 JAAQPE010000535|CGC2 248869.92 6.5979
Genome Property
Genome Version/Assembly ID Genes Strain NCBI Taxon ID Non Protein Coding Genes Protein Coding Genes
FungiDB-61_FcircinatumNRRL25331 13905 N/A 0 13905
Gene Location

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in KAF5659801.1.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH106 1285 2250 3.4e-94 0.9927184466019418

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
407266 Glyco_hydro_106 6.10e-25 1430 1994 321 865
alpha-L-rhamnosidase.
270622 PKc 1.09e-22 154 317 48 204
Catalytic domain of Protein Kinases. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.
270901 STKc_MAP3K-like 2.80e-21 153 299 46 182
Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed mainly of MAP3Ks and similar proteins, including TGF-beta Activated Kinase-1 (TAK1, also called MAP3K7), MAP3K12, MAP3K13, Mixed lineage kinase (MLK), MLK-Like mitogen-activated protein Triple Kinase (MLTK), and Raf (Rapidly Accelerated Fibrosarcoma) kinases. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Also included in this subfamily is the pseudokinase Kinase Suppressor of Ras (KSR), which is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway.
214567 S_TKc 3.82e-18 154 294 54 182
Serine/Threonine protein kinases, catalytic domain. Phosphotransferases. Serine or threonine-specific kinase subfamily.
270910 STKc_LKB1_CaMKK 4.01e-18 154 322 61 230
Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Both LKB1 and CaMKKs can phosphorylate and activate AMP-activated protein kinase (AMPK). LKB1, also called STK11, serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMPK. Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The LKB1/CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
0.0 1255 2258 1 1021
0.0 1255 2257 1 1009
0.0 1255 2257 1 1009
0.0 1255 2258 1 1010
0.0 1255 2258 1 1010

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
4.82e-12 154 314 60 211
Crystal structure of BMX non-receptor tyrosine kinase complex with dasatinib [Homo sapiens],3SXR_B Crystal structure of BMX non-receptor tyrosine kinase complex with dasatinib [Homo sapiens],3SXS_A Crystal structure of BMX non-receptor tyrosine kinase complexed with PP2 [Homo sapiens]
5.55e-12 154 314 70 221
Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24 [Homo sapiens],6I99_B Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24 [Homo sapiens]
7.39e-10 154 303 70 223
Crystal structure of RIP1 kinase in complex with necrostatin-1 analog [Homo sapiens],4ITH_B Crystal structure of RIP1 kinase in complex with necrostatin-1 analog [Homo sapiens],4ITI_A Crystal structure of RIP1 kinase in complex with necrostatin-3 analog [Homo sapiens],4ITI_B Crystal structure of RIP1 kinase in complex with necrostatin-3 analog [Homo sapiens],4ITJ_A Crystal structure of RIP1 kinase in complex with necrostatin-4 [Homo sapiens],4ITJ_B Crystal structure of RIP1 kinase in complex with necrostatin-4 [Homo sapiens]
7.54e-10 154 303 72 225
Structure of human RIPK1 kinase domain in complex with GNE684 [Homo sapiens],6NYH_B Structure of human RIPK1 kinase domain in complex with GNE684 [Homo sapiens]
7.62e-10 154 303 73 226
Chain A, Receptor-interacting serine/threonine-protein kinase 1 [Homo sapiens],7FCZ_B Chain B, Receptor-interacting serine/threonine-protein kinase 1 [Homo sapiens],7FD0_A Chain A, Receptor-interacting serine/threonine-protein kinase 1 [Homo sapiens],7FD0_B Chain B, Receptor-interacting serine/threonine-protein kinase 1 [Homo sapiens]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1.78e-11 154 299 839 978
Putative serine/threonine-protein kinase/receptor R826 OS=Acanthamoeba polyphaga mimivirus OX=212035 GN=MIMI_R826 PE=3 SV=2
2.01e-11 154 299 142 277
Serine/threonine/tyrosine-protein kinase HT1 OS=Arabidopsis thaliana OX=3702 GN=HT1 PE=1 SV=1
5.22e-11 154 299 838 978
Putative serine/threonine-protein kinase/receptor R831 OS=Acanthamoeba polyphaga mimivirus OX=212035 GN=MIMI_R831 PE=3 SV=2
7.76e-11 154 314 443 594
Cytoplasmic tyrosine-protein kinase BMX OS=Mus musculus OX=10090 GN=Bmx PE=2 SV=1
2.38e-10 154 314 467 618
Cytoplasmic tyrosine-protein kinase BMX OS=Homo sapiens OX=9606 GN=BMX PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI CS Position
0.999971 0.000076

TMHMM  Annotations      help

There is no transmembrane helices in KAF5659801.1.