CAZyme Information: HMPREF1544_00526-t46_1-p1

Basic Information

• Species: Mucor circinelloides
• Lineage: Mucoromycota; Mucoromycetes; ; Mucoraceae; Mucor; Mucor circinelloides
• CAZyme ID: HMPREF1544_00526-t46_1-p1
• CAZy Family: AA3
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
741		83528.50	7.1153

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_Mcircinelloides1006PhL	12410	1220926	183	12227

• Gene Location: location=KE123899:66685-68960(+)

Full Sequence      

MVSLHSNTIRQRGLFDSSTTTGQVSHLPFQFNTRKWRWWNYVSALVSIIVCVELILLMVS
MILLALAPDPITFRIQQNYPKVPYQPLDTATPITLAPGSNVYHVTKEFGPATMGGMGTVL
TAMTQAQLRTGKIQPNVVLPFYSFLKKQEQYPIKKTVDLVISFRDDHQQPVNVEFRVSEM
QYDFEPIPNFNSLPEEDKLAIIAARQTKPKIKVYLIGPGKLDPLRKAFRAGSITQIYSSP
KGLPQEWKDQYFTKAAASFLVWRAAGKHEQSLFAPLTSQQPKVDVVHLHGATNAYVAKFL
SEYESQLGATPPAIIYTIHDYLDELQYTNTLPNVERFLNTPRHGKDLKQEMHSVLVPYTF
GSNKMFMSPLAVDIADTVTFVSQTMAKDMVEGKLDFYLKEVVMENILRKAEVGQFYGVSN
GVDFGGSVNPFTEQKLVEAGLQYSDFARTLINAKLDYANDMADATAATAAKHWSLSAYHA
DYVTSAKQKAKQFLVDQGLLNAADLNRPLVLYVGRFQYNKGLETFEEAARLFKLHDMKFA
IIGQPNNYPLNWVKRLAANDPENIVLMTHTSEQRKWLIYFRAAADFVYVPSITESFGLVA
AEGLLFGSSVISTGTGGLAEFLVDRQLDNEAPSEIVSEQLVESHYRFNAYLFDALATAGD
RQLSQAILRAATDYQHMQRIPALHETYVLRMMLSAYSLGWERAGVEQGPVYDYLRIYQQA
IYDKRSKSSFALAGDDLDERR

Enzyme Prediction     

No EC number prediction in HMPREF1544_00526-t46_1-p1.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT5	100	685	1.4e-43	0.951271186440678

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
340822	GT5_Glycogen_synthase_DULL1-like	5.71e-27	100	719	1	474	Glycogen synthase GlgA and similar proteins. This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.
223374	GlgA	1.19e-18	100	721	2	479	Glycogen synthase [Carbohydrate transport and metabolism].
340831	GT4_PimA-like	9.50e-15	506	671	191	344	phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.
223515	RfaB	1.12e-14	504	724	196	381	Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis].
395425	Glycos_transf_1	1.43e-14	506	624	1	119	Glycosyl transferases group 1. Mutations in this domain of PIGA lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
CDS06183.1|GT0	5.19e-204	34	741	88	819
CDS14426.1|GT0	1.23e-176	28	721	57	720
CDR38054.1|GT0	7.37e-105	37	727	76	811
CCO66643.1|GT5	2.94e-18	89	714	208	715
APJ04654.1|GT5	5.98e-16	100	623	190	632

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2BFW_A	2.59e-07	476	624	9	156	Structure of the C domain of glycogen synthase from Pyrococcus abyssi [Pyrococcus abyssi]
6FJ3_A	1.06e-06	469	624	321	475	High resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist. [Homo sapiens]
3L01_A	1.11e-06	476	624	224	371	Chain A, GlgA glycogen synthase [Pyrococcus abyssi],3L01_B Chain B, GlgA glycogen synthase [Pyrococcus abyssi]
3FRO_A	1.13e-06	476	624	224	371	Crystal structure of Pyrococcus abyssi glycogen synthase with open and closed conformations [Pyrococcus abyssi],3FRO_B Crystal structure of Pyrococcus abyssi glycogen synthase with open and closed conformations [Pyrococcus abyssi],3FRO_C Crystal structure of Pyrococcus abyssi glycogen synthase with open and closed conformations [Pyrococcus abyssi]
2BIS_A	1.14e-06	476	624	225	372	Structure of glycogen synthase from Pyrococcus abyssi [Pyrococcus abyssi],2BIS_B Structure of glycogen synthase from Pyrococcus abyssi [Pyrococcus abyssi],2BIS_C Structure of glycogen synthase from Pyrococcus abyssi [Pyrococcus abyssi]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q2JNM6|GLGA1_SYNJB	2.89e-10	487	715	281	489	Glycogen synthase 1 OS=Synechococcus sp. (strain JA-2-3B'a(2-13)) OX=321332 GN=glgA1 PE=3 SV=1
sp|Q2JSZ9|GLGA1_SYNJA	5.05e-10	487	715	281	489	Glycogen synthase 1 OS=Synechococcus sp. (strain JA-3-3Ab) OX=321327 GN=glgA1 PE=3 SV=1
sp|B4U626|GLGA_HYDS0	1.85e-08	113	720	16	476	Glycogen synthase OS=Hydrogenobaculum sp. (strain Y04AAS1) OX=380749 GN=glgA PE=3 SV=1
sp|Q604D9|GLGA2_METCA	2.47e-08	251	715	111	485	Glycogen synthase 2 OS=Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) OX=243233 GN=glgA2 PE=3 SV=2
sp|B2V5P9|GLGA_SULSY	4.22e-08	375	624	207	405	Glycogen synthase OS=Sulfurihydrogenibium sp. (strain YO3AOP1) OX=436114 GN=glgA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
0.999984	0.000039

TMHMM  Annotations     

Start	End
42	64