CAZyme Information: HMPREF1541_03566-t46_1-p1

Basic Information

• Species: Cyphellophora europaea
• Lineage: Ascomycota; Eurotiomycetes; ; Cyphellophoraceae; Cyphellophora; Cyphellophora europaea
• CAZyme ID: HMPREF1541_03566-t46_1-p1
• CAZy Family: GH128
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
688	KB822719|CGC27	71266.60	5.2042

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_CeuropaeaCBS101466	11153	1220924	59	11094

• Gene Location: location=KB822719:1764835-1766901(+)

Full Sequence      

MRPKSWLTKVVLNEGYRARGLSVPVSPCDFQRTTSFVPAAGFIRTAFHDVAGHDSATGVG
GLDASIAFELTGEHGKDNAGPFANNSLTFLARYYSVQASMADLMALGLYTSVRSCGGPDI
ATRTGRIDAQEAGPFGVPKPNDTQQGYKDTFSRIGFNPQEMIKLVACGHTLGGVHREQFP
QIATKENMSPFDSTESKFDNRVAVEYVSNTTRNPLVTGPNDSFRSDKIIFTIDHDKTIKQ
LTDAQTFQNECKIIMQKMIDTVPGSVTLSEPIQVYDVKPGSLSLALSGNGTIVFNGEIRV
RTTQGQVANVSLVYKNRDGIKGNNTISTAFAGTANGHDDSFVFYSFSASLPAKSSITSFD
VIVTGADGSTTTYNNNGKSFPVQDNIFVQLPDCSVSATTPAGKASVNIVAAVRGSAASVT
LSATTHTQRDVPMPLLSTNKVTMTKGSSVGEYTYYEGTFEVASQQLATATFDISAEIDGK
TVEDKFHHVAGFGGSTGPDGDNNDGGDDGGNGNSGGGSDWINIPDRGNTDAPGSSSGAIP
DKPYTPSRPCGELEGCETLPWVHDLPMPGPDTFAPPGSPNAPVHGSSSGSYGGTGGDRWN
GGKGGGGNGGSGGGHGADDDGQGGNGGNGGISGGGHVPVAPTSPVGPVETSGSSPPTSPV
TPYTGAASKIRGISSFFISITGLAIMTV

Enzyme Prediction     

No EC number prediction in HMPREF1541_03566-t46_1-p1.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
AA2	39	258	5.3e-29	0.8901960784313725

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
173829	plant_peroxidase_like_1	5.04e-93	10	260	12	264	Uncharacterized family of plant peroxidase-like proteins. This is a subgroup of heme-dependent peroxidases similar to plant peroxidases. Along with animal peroxidases, these enzymes belong to a group of peroxidases containing a heme prosthetic group (ferriprotoporphyrin IX) which catalyzes a multistep oxidative reaction involving hydrogen peroxide as the electron acceptor. The plant peroxidase-like superfamily is found in all three kingdoms of life and carries out a variety of biosynthetic and degradative functions.
173823	plant_peroxidase_like	2.62e-23	38	259	17	254	Heme-dependent peroxidases similar to plant peroxidases. Along with animal peroxidases, these enzymes belong to a group of peroxidases containing a heme prosthetic group (ferriprotoporphyrin IX), which catalyzes a multistep oxidative reaction involving hydrogen peroxide as the electron acceptor. The plant peroxidase-like superfamily is found in all three kingdoms of life and carries out a variety of biosynthetic and degradative functions. Several sub-families can be identified. Class I includes intracellular peroxidases present in fungi, plants, archaea and bacteria, called catalase-peroxidases, that can exhibit both catalase and broad-spectrum peroxidase activities depending on the steady-state concentration of hydrogen peroxide. Catalase-peroxidases are typically comprised of two homologous domains that probably arose via a single gene duplication event. Class II includes ligninase and other extracellular fungal peroxidases, while class III is comprised of classic extracellular plant peroxidases, like horseradish peroxidase.
395089	peroxidase	2.33e-20	39	177	16	157	Peroxidase.
173825	ascorbate_peroxidase	3.18e-17	42	200	33	187	Ascorbate peroxidases and cytochrome C peroxidases. Ascorbate peroxidases are a subgroup of heme-dependent peroxidases of the plant superfamily that share a heme prosthetic group and catalyze a multistep oxidative reaction involving hydrogen peroxide as the electron acceptor. Along with related catalase-peroxidases, ascorbate peroxidases belong to class I of the plant superfamily. Ascorbate peroxidases are found in the chloroplasts and/or cytosol of algae and plants, where they have been shown to control the concentration of lethal hydrogen peroxide molecules. The yeast cytochrome c peroxidase is a divergent member of the family; it forms a complex with cytochrome c to catalyze the reduction of hydrogen peroxide to water.
173826	ligninase	1.36e-11	43	218	42	218	Ligninase and other manganese-dependent fungal peroxidases. Ligninases and related extracellular fungal peroxidases belong to class II of the plant heme-dependent peroxidase superfamily. All members of the superfamily share a heme prosthetic group and catalyze a multistep oxidative reaction involving hydrogen peroxide as the electron acceptor. Class II peroxidases are fungal glycoproteins that have been implicated in the oxidative breakdown of lignin, the main cell wall component of woody plants. They contain four conserved disulphide bridges and two conserved calcium binding sites.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QGA18666.1|AA5_1	3.43e-107	12	477	38	516
QBZ57066.1|AA0	2.99e-99	15	498	43	537
VBB76056.1|AA0	2.34e-92	3	497	32	535
QRV94524.1|AA2	1.09e-89	12	486	36	522
QRV79935.1|AA2	4.20e-89	12	486	36	522

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3RIW_A	2.54e-10	43	177	31	168	The Crystal Structure of Leishmania major Peroxidase mutant C197T [Leishmania major strain Friedlin],3RIW_B The Crystal Structure of Leishmania major Peroxidase mutant C197T [Leishmania major strain Friedlin]
4GED_A	3.30e-10	43	177	30	167	Crystal Structure of the Leishmania Major Peroxidase-Cytochrome C Complex [Leishmania major]
5AL9_A	3.38e-10	43	177	30	167	Structure of Leishmania major peroxidase D211R mutant (high res) [Leishmania major],5ALA_A Structure of Leishmania major peroxidase D211R mutant (low res) [Leishmania major],5ALA_B Structure of Leishmania major peroxidase D211R mutant (low res) [Leishmania major]
5AMM_A	3.38e-10	43	177	30	167	Structure of Leishmania major peroxidase D211N mutant [Leishmania major],5AMM_B Structure of Leishmania major peroxidase D211N mutant [Leishmania major]
3RIV_A	3.42e-10	43	177	31	168	The Crystal Structure of Leishmania major Peroxidase [Leishmania major strain Friedlin],3RIV_B The Crystal Structure of Leishmania major Peroxidase [Leishmania major strain Friedlin]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|D4AUF4|WSCD2_ARTBC	6.61e-109	1	500	18	516	WSC domain-containing protein ARB_07870 OS=Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) OX=663331 GN=ARB_07870 PE=1 SV=1
sp|Q4WPF8|CCPR_ASPFU	3.57e-08	43	219	122	294	Cytochrome c peroxidase, mitochondrial OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=ccp1 PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
0.999884	0.000147

TMHMM  Annotations     

There is no transmembrane helices in HMPREF1541_03566-t46_1-p1.