CAZyme Information: HCEG_07762-t36_1-p1

Basic Information

• Species: Histoplasma capsulatum
• Lineage: Ascomycota; Eurotiomycetes; ; Ajellomycetaceae; Histoplasma; Histoplasma capsulatum
• CAZyme ID: HCEG_07762-t36_1-p1
• CAZy Family: GT31
• CAZyme Description: integral membrane protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
402	DS990641|CGC4	43702.54	9.9853

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_HcapsulatumH88	9666	544711	221	9445

• Gene Location: location=DS990641:1931498-1932795(-)

Full Sequence      

MRLFSTVVTAAMLVNASMAFIQTAQFRPGDEKGISYSVNVPPSTASRGQGPIYFQMEAPS
DTTEWFSLGQGTGMAGANIFVAYISSDKKNITISPRLGRGHMLPDYNPSAQVRLLDGSGI
SNGKIIAKVLCESCMSWDGGSMNPTDTKSPWIWAVKRGNPLNSADVEASIPFHDNQGTFT
FDLTVDADRGDGSSGSTPGISQRTIDIKRVTHGIIMSVVFVILFPTFALTLFLIPYSKTA
TRIHAPLQILTLCAAVTGFGVGVSLSLDLKRATMYHPIIGYVVIGWLLLFQPLLGYWHHL
NYMRTRGPSAMGLVHRWVGRSMLVLGIINGGLGFKFSGIGEETVPKAGVIVYAILAGVIS
VAYIIILTWGTSKKKKNQQRLRSDESFFDSENIKLADGRRRG

Enzyme Prediction     

No EC number prediction in HCEG_07762-t36_1-p1.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
AA8	29	186	1.8e-19	0.8736263736263736

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
187688	CDH_like_cytochrome	1.23e-57	21	183	9	168	Heme-binding cytochrome domain of fungal cellobiose dehydrogenases. Cellobiose dehydrogenase (CellobioseDH or CDH) is an extracellular fungal oxidoreductase that degrades both lignin and cellulose. Specifically, CDHs oxidize cellobiose, cellodextrins, and lactose to corresponding lactones, utilizing a variety of electron acceptors. Class-II CDHs are monomeric hemoflavoenzymes that are comprised of a b-type cytochrome domain linked to a large flavodehydrogenase domain. The cytochrome domain of CDH and related enzymes, which this model describes, folds as a beta sandwich and complexes a heme molecule. It is found at the N-terminus of this family of enzymes, and belongs to the DOMON domain superfamily, a ligand-interacting motif found in all three kingdoms of life.
176490	Cyt_b561_FRRS1_like	8.30e-35	175	366	1	189	Eukaryotic cytochrome b(561), including the FRRS1 gene product. Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.
406418	CDH-cyt	3.72e-28	33	184	19	171	Cytochrome domain of cellobiose dehydrogenase. CDH-cyt is the cytochrome domain, at the N-terminus, of cellobiose dehydrogenase. CDH-cyt folds as a beta sandwich with the topology of the antibody Fab V(H) domain and binds iron. The haem iron is ligated by Met83 and His181 in UniProtKB:Q01738.
214769	B561	2.28e-08	211	334	1	129	Cytochrome b-561 / ferric reductase transmembrane domain. Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.
176491	Cyt_b561_CYB561D2_like	1.86e-06	212	362	24	181	Eukaryotic cytochrome b(561), including the CYB561D2 gene product. Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
SMR42136.1|AA0	4.64e-76	9	390	7	405
SMR44317.1|AA0	4.64e-76	9	390	7	405
CAE7013938.1|AA8	4.44e-73	33	376	30	386
UJO18045.1|AA0	2.40e-72	5	384	3	393
SMR55355.1|AA0	2.70e-68	9	396	2	389

PDB Hits     

HCEG_07762-t36_1-p1 has no PDB hit.

Swiss-Prot Hits     

HCEG_07762-t36_1-p1 has no Swissprot hit.

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000377	0.999588	CS pos: 19-20. Pr: 0.9715

TMHMM  Annotations     

Start	End
214	236
243	265
275	297
317	339
349	371