CAZyme Information: HCDG_03533-t38_1-p1

Basic Information

• Species: Histoplasma capsulatum
• Lineage: Ascomycota; Eurotiomycetes; ; Ajellomycetaceae; Histoplasma; Histoplasma capsulatum
• CAZyme ID: HCDG_03533-t38_1-p1
• CAZy Family: GH18
• CAZyme Description: DUF1237 domain-containing protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
877	GG692422|CGC2	97232.85	6.2679

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_HcapsulatumH143	9796	544712	249	9547

• Gene Location: location=GG692422:962960-967566(+)

Full Sequence      

MAANYKKYLAEKVLNEQDIVTHRALSRALKVHSNLAKRVEPTRLQDLNVLGDIGHDIMQP
QPNDPLEYGKQYGMILNRNVKAEHSGPEDVVLDDASEEEREDLFLDTGTRRSNSKRESRK
EREEKLRKMMEDVPEDVPELPPARAPERTDTSQSEEVPKAESKEEASAPKGRRRGRRQVM
KKTTIKDAEGYLVTKEEPVWESFSEDEAPPPVKRKPAVSVNSKPTSSNKGSQKTGQGNII
ARITGFEPVPTIFGPKPMLVQRSAVTETRREPQDPRAWNRSARDPGLSRVLGTFALSFGQ
ISGCPSTGCAAETPLARGDQAGAIAIALLHVLARDMRALPWTAAVLAALVSNGALAGSSH
PDDAASLAVACPDYSEYSKLKHPPYSEGPLQLPFQRPVLPCRTFASTFIEKVIEDVTSRM
VDKDLAQLFRNAYPNTADTTVRWHVDSSDPRSKILTQYPQSESWQGPQSFIVTGDINAEW
LRDSANQVAGYQMLAAKDPKIKTLILGAINTQVEFVLQSPYCNAFQPPPPSGLLHTIPQT
QSDIVHPAYEQSVVFECKYELDSLANFLAIGNKFFAETKSTEFVTTRWYRAVLTVLQVIE
EQSKPTFDDQGEYVRNTYTFKRLTTLGTETLNLDGVGNPLNNGTGLVRSAFRPSDDATIF
GYFIPANAYLSVELKRTALTIKAAGGPDSLIQTLEQRASIVEKGIRDHGIVSHKKFGEVY
AFEVDGYGSRLLMDDANLPSLLSLPLLGFVDKDDEVYQNTRKMLLTKTGNPYYLTGTQFH
GIGGPHAGLSNAWPMSVLVRARTSDDDEEIMESINMVRNASLLGLIHESVDVDNIRVYTR
SWFAWANSVFAQTILELAERKPYLLFGKGASPYKAGE

Enzyme Prediction     

No EC number prediction in HCDG_03533-t38_1-p1.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH125	422	855	3.3e-158	0.9975124378109452

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
399660	Glyco_hydro_125	0.0	422	855	1	416	Metal-independent alpha-mannosidase (GH125). This family, which contains bacterial and fungal glycoside hydrolases, is also known as GH125. They function as metal-independent alpha-mannosidases, with specificity for alpha-1,6-linked non-reducing terminal mannose residues. Structurally this family is part of the 6 hairpin glycosidase superfamily.
226068	COG3538	1.18e-143	401	865	2	430	Meiotically up-regulated gene 157 (Mug157) protein (function unknown) [Function unknown].
370537	CDC27	3.84e-63	19	239	2	420	DNA polymerase subunit Cdc27. This protein forms the C subunit of DNA polymerase delta. It carries the essential residues for binding to the Pol1 subunit of polymerase alpha, from residues 293-332, which are characterized by the motif D--G--VT, referred to as the DPIM motif. The first 160 residues of the protein form the minimal domain for binding to the B subunit, Cdc1, of polymerase delta, the final 10 C-terminal residues, 362-372, being the DNA sliding clamp, PCNA, binding motif.
406410	CARMIL_C	0.006	77	229	85	271	CARMIL C-terminus. This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).
236766	rne	0.007	77	237	642	792	ribonuclease E; Reviewed

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QSS49978.1|GH125	0.0	336	877	1	542
QSS68485.1|GH125	0.0	336	877	1	542
QSS59948.1|GH125	0.0	336	877	1	542
QVM13217.1|GH125	7.66e-259	344	877	9	547
CAK38960.1|GH125	3.41e-251	336	873	1	533

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2P0V_A	8.87e-88	396	857	43	468	Crystal structure of BT3781 protein from Bacteroides thetaiotaomicron, Northeast Structural Genomics Target BtR58 [Bacteroides thetaiotaomicron VPI-5482],2P0V_B Crystal structure of BT3781 protein from Bacteroides thetaiotaomicron, Northeast Structural Genomics Target BtR58 [Bacteroides thetaiotaomicron VPI-5482]
3ON6_A	2.21e-85	396	857	23	448	Crystal structure of an exo-alpha-1,6-mannosidase (bacova_03626) from bacteroides ovatus at 1.70 a resolution [Bacteroides ovatus ATCC 8483],3ON6_B Crystal structure of an exo-alpha-1,6-mannosidase (bacova_03626) from bacteroides ovatus at 1.70 a resolution [Bacteroides ovatus ATCC 8483]
3P2C_A	9.11e-83	396	857	21	450	Crystal structure of an exo-alpha-1,6-mannosidase (bacova_03347) from bacteroides ovatus at 1.60 a resolution [Bacteroides ovatus ATCC 8483],3P2C_B Crystal structure of an exo-alpha-1,6-mannosidase (bacova_03347) from bacteroides ovatus at 1.60 a resolution [Bacteroides ovatus ATCC 8483]
6RQK_A	2.19e-73	409	856	12	421	Crystal structure of GH125 1,6-alpha-mannosidase from Clostridium perfringens in complex with mannoimidazole [Clostridium perfringens str. 13],6RQK_B Crystal structure of GH125 1,6-alpha-mannosidase from Clostridium perfringens in complex with mannoimidazole [Clostridium perfringens str. 13]
3QT3_A	2.44e-73	409	856	12	421	Analysis of a New Family of Widely Distributed Metal-independent alpha-Mannosidases Provides Unique Insight into the Processing of N-linked Glycans, Clostridium perfringens CPE0426 apo-structure [Clostridium perfringens],3QT9_A Analysis of a new family of widely distributed metal-independent alpha mannosidases provides unique insight into the processing of N-linked glycans, Clostridium perfringens CPE0426 complexed with alpha-1,6-linked 1-thio-alpha-mannobiose [Clostridium perfringens]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q10449|MU157_SCHPO	1.89e-175	370	865	26	504	Meiotically up-regulated gene 157 protein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=mug157 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
1.000070	0.000000

TMHMM  Annotations     

There is no transmembrane helices in HCDG_03533-t38_1-p1.