CAZyme Information: HCDG_01330-t38_1-p1

Basic Information

• Species: Histoplasma capsulatum
• Lineage: Ascomycota; Eurotiomycetes; ; Ajellomycetaceae; Histoplasma; Histoplasma capsulatum
• CAZyme ID: HCDG_01330-t38_1-p1
• CAZy Family: AA7
• CAZyme Description: glyoxal oxidase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
617	GG692419|CGC5	67437.52	5.0641

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_HcapsulatumH143	9796	544712	249	9547

• Gene Location: location=GG692419:5683183-5685198(+)

Full Sequence      

MGANSSVSLGAPQNLMNPSNLSTNKVHRMTLRQKQEEKPKLDLKETIDGLCGPENGDTIC
GDWPGGSCCSAYGSGECESGNLFEILSPNTHAPDTIHGTFKVVGQSGVPAMSAALLANGR
VVFIDKVENYTQLILDNGQYAYSSEYDPSTNMAAPLRYETNAFCSGGAFLEDGRLISIGG
NSPLPMDPTVGDGFRALRYLTRPLDTKAWDGKSWDEPGNKLSTNRWYASAQTLRDGTVFV
VSGSLNGLNPSVIANNNPTYELLNKDGIPFGHSVLFPILEENQPYYMYPFLHLLKDGTVF
VFVARSAEIFDAHGQKTVKKLPDLPGDYRSYPNTGGSVLLPLRAANGWDDEIIICGGGAF
VGIASPTDPSCGRIKPLSKDPQWELELMPDGRVMVEGMMLPDGKLIWLNGCNRGAQGFGI
AKDPSLDAWIYDPEAPLGRRWSIGGKTEIARMYHSVALVLLDGTVMIAGSNPVEQPILVP
NPDVAEQAFATEFRVEIYTPHYLLDGRDKFRPYDVELPNKHLLVDSEPFTVDFKLHTEPN
DLRVVLYHGGFVTHSLHMGHRMLYLDHVGYQPQSKSQTILVTMPPDNNIAPPGPYVVYVV
ADGVPSIGVFVMVEAKR

Enzyme Prediction     

No EC number prediction in HCDG_01330-t38_1-p1.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
AA5	97	614	9.8e-148	0.9502664298401421

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
399910	Glyoxal_oxid_N	1.20e-54	111	357	1	243	Glyoxal oxidase N-terminus. This family represents the N-terminus (approximately 300 residues) of a number of plant and fungal glyoxal oxidase enzymes. Glyoxal oxidase catalyzes the oxidation of aldehydes to carboxylic acids, coupled with reduction of dioxygen to hydrogen peroxide. It is an essential component of the extracellular lignin degradation pathways of the wood-rot fungus Phanerochaete chrysosporium.
401164	DUF1929	2.40e-31	527	613	10	91	Domain of unknown function (DUF1929). Members of this family adopt a secondary structure consisting of a bundle of seven, mostly antiparallel, beta-strands surrounding a hydrophobic core. The 7 strands are arranged in 2 sheets, in a Greek-key topology. Their precise function, has not, as yet, been defined, though they are mostly found in sugar-utilising enzymes, such as galactose oxidase.
199882	E_set_GO_C	2.21e-28	506	613	1	103	C-terminal Early set domain associated with the catalytic domain of galactose oxidase. E or "early" set domains are associated with the catalytic domain of galactose oxidase at the C-terminal end. Galactose oxidase is an extracellular monomeric enzyme which catalyzes the stereospecific oxidation of a broad range of primary alcohol substrates and possesses a unique mononuclear copper site essential for catalyzing a two-electron transfer reaction during the oxidation of primary alcohols to corresponding aldehydes. The second redox active center necessary for the reaction was found to be situated at a tyrosine residue. The C-terminal domain of galactose oxidase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family include members of the alpha amylase family, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase, among others.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QSS69861.1|AA5|CBM18	0.0	1	617	1	631
QSS64055.1|AA5|CBM18	0.0	1	617	1	631
QRC90698.1|AA5|CBM18	6.52e-227	98	614	316	827
QKX63834.1|AA5	5.75e-225	89	614	46	568
QGA21118.1|AA5	7.91e-224	100	614	70	583

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2WQ8_A	1.36e-11	108	607	192	653	Chain A, GALACTOSE OXIDASE [Fusarium graminearum]
6XLT_A	1.23e-10	108	607	171	632	Chain A, Galactose oxidase [Fusarium graminearum]
1T2X_A	1.61e-10	108	607	170	631	Glactose oxidase C383S mutant identified by directed evolution [Fusarium sp.]
2EIC_A	2.12e-10	108	607	170	631	Chain A, Galactose oxidase [Fusarium graminearum]
1GOF_A	3.69e-10	108	607	170	631	NOVEL THIOETHER BOND REVEALED BY A 1.7 ANGSTROMS CRYSTAL STRUCTURE OF GALACTOSE OXIDASE [Hypomyces rosellus],1GOG_A NOVEL THIOETHER BOND REVEALED BY A 1.7 ANGSTROMS CRYSTAL STRUCTURE OF GALACTOSE OXIDASE [Hypomyces rosellus],1GOH_A NOVEL THIOETHER BOND REVEALED BY A 1.7 ANGSTROMS CRYSTAL STRUCTURE OF GALACTOSE OXIDASE [Hypomyces rosellus],2EIE_A Chain A, Galactose oxidase [Fusarium graminearum],2JKX_A Chain A, GALACTOSE OXIDASE [Fusarium graminearum],2VZ1_A Chain A, GALACTOSE OXIDASE [Fusarium graminearum],2VZ3_A Chain A, Galactose Oxidase [Fusarium graminearum]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q3HRQ2|GLOX_VITPS	2.75e-70	98	607	15	515	Aldehyde oxidase GLOX OS=Vitis pseudoreticulata OX=231512 GN=GLOX PE=2 SV=1
sp|Q9FYG4|GLOX1_ARATH	3.76e-58	105	613	104	614	Aldehyde oxidase GLOX1 OS=Arabidopsis thaliana OX=3702 GN=GLOX1 PE=2 SV=1
sp|D4AUF1|WSCD1_ARTBC	2.41e-53	102	613	425	903	WSC domain-containing protein ARB_07867 OS=Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) OX=663331 GN=ARB_07867 PE=1 SV=1
sp|A0A2H4HHY6|GLOX_ARTAN	4.05e-53	105	614	76	594	Putative aldehyde oxidase Art an 7 OS=Artemisia annua OX=35608 PE=1 SV=1
sp|Q01772|GLOX_PHACH	4.65e-49	106	612	35	548	Aldehyde oxidase GLOX OS=Phanerodontia chrysosporium OX=2822231 GN=GLX PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
1.000022	0.000007

TMHMM  Annotations     

There is no transmembrane helices in HCDG_01330-t38_1-p1.